GenomeNet

Database: UniProt
Entry: W5P2Z5_SHEEP
LinkDB: W5P2Z5_SHEEP
Original site: W5P2Z5_SHEEP 
ID   W5P2Z5_SHEEP            Unreviewed;      1692 AA.
AC   W5P2Z5;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   07-JUN-2017, entry version 23.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN7A {ECO:0000313|Ensembl:ENSOARP00000004795};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000004795, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000004795, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000004795};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000004795}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOARP00000004795}.
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DR   EMBL; AMGL01052904; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSOART00000004876; ENSOARP00000004795; ENSOARG00000004467.
DR   GeneTree; ENSGT00830000128242; -.
DR   OMA; GMYNFAY; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000002356; Chromosome 2.
DR   GO; GO:0097386; C:glial cell projection; IEA:Ensembl.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0006936; P:muscle contraction; IEA:InterPro.
DR   GO; GO:0055078; P:sodium ion homeostasis; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028812; Na_channel_a7su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   PANTHER; PTHR10037:SF269; PTHR10037:SF269; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    246    268       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    378    404       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    516    534       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    546    566       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    586    605       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    641    659       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    718    741       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    981    999       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1011   1028       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1070   1092       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1178   1205       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1262   1280       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1292   1314       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1326   1350       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1389   1415       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1427   1446       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1483   1509       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      132    413       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      516    740       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      755    938       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      944   1209       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1261   1509       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   1692 AA;  194798 MW;  12DC23C8B1CF6661 CRC64;
     MASPEPKSLV PFTRESLEVM EQHSAKKPSE EDKEDLKPNC DLEVGKELPF VYGNLPQAMV
     SEPLEDVDPY YTNKRTFIVL NKKRTIFRFS ATWCTLSPFN SIRRATIKIL VHPYPFLLVL
     NCTNIKCNNS IQILLHVLTD CIFMSMTDCP KWGPAFQNTL LGIYTFEILV KLIARGIWAG
     PFYFFGDSWN WLDFSVTLFE HISRYSPLNF ISVFRIVRNL RILKIIPLNQ GMKSFVAILI
     HCLKKLTVVI ILTVFFLSVF SLIGMGLFMG NLKHKCLRWP QENETDMLNN RTGNPYYIRE
     TENFYYLEGE RYALLCGNRS DASQCPEGYV CVKAGVNPDD GYTNFDSFGW ALLALFRLMT
     QDYPEALYHQ ILYASGKVYM IFFVVISFWF AFYMASLFLG LLAISYEEEK QTAAEKATVD
     QEFQKSLPEL QEEKITAETK TIQLEMKKRS SPSMITSLDA LDDATVSHKE VSELKKSRQR
     CPFCWYRFAK TFLIWDCSPC WLKLKEFVYR IIMDPFTDLF LTICIILNIN FLALEHYPMS
     LETSNILSIG NMVFIGIFTT EMIFKIIAMH PYGYFQVGWN IYDSLIVFHG LAELYLTNFH
     GLAILRSFRV LRIFRLGRYW PTFKILMLTL CNSVVALKDL VLLLFTFMFF SAVVGLNLYG
     SNYKQYVCNI NEDCQLPHWH MCDFFHSFLN VFRILCGEWI ETLWDCFKVA GQFSCIPFYM
     MVILIGKLLI LYLFLALIIS FSSYKPATTD EENDEAKNLQ RAMARIKKGI NYVLSKILCK
     KQNVLKETMD NISDVYVKEN ISGHTLSELS NTQDFLKDKE KSSGTEKNTM TENESRSLIP
     SPSVSETVPI ASEESDIENP DNKEIQNKSG DGSSKEKVKQ SSSSECSTVD IVLSEEEMVY
     EREKPKHLRN VYERRSSSAQ IGRGPKKGKI WQNIRKTCCK IVENSCFKCF IGLVTLLSTG
     ALAFEDIYID QRKTIKILLE YADMIFTYIF ILEMLLKWMA YGFKAYFTND WYKLDFMVVI
     VFCLSLIGKS REELKPLVSI KFLRALRVLS QFEKMKVVVS ALIKTTLPTL SVFLVCLMIW
     LAFGIIGVHL FAGKFYECID PTSGERFPLS EVMNRSQCET LVFNESMPWE NAKLNFDNVG
     ISFLSLLQVA TFNGWITIMN SAVDSTDVDM QPHFENNIYM YCYFIDFIII GLFLPLSMLI
     GAIVANFHKH KIKGGSNIFI TVKQKKQYRA LKKLMYEDSQ KPVPLPENKF QRFIFDLVTS
     RVFNIIIMTL ICFQAITIMI QSDEQSPKID TALFWINSVY VGLYIGECVL KLIVFHCNYF
     TSGWNIFDFM VVVFSITGLF LPLMVGYYLV SPSLVQLILL SRIIHILHPE KGLKLFHNLL
     LPLMLSLPAL LNISLLIFLI MFIYAIFGMY NFAYVKKEAG IDDMSNFETF GSSMLCLFRV
     TIFAGWDGML NAIFNSKWSD CDPDKINPGT QVRGDCGNPF LGIIYFVSYI LLTRLIIVNM
     YIVVVMEFLN IASKKKAKTL SEEDFRKFFQ VWKRFDPDRT QYIDSSKLSD FAAALDPPLF
     MAKPNKGQLV SMDLPMAVGD RIHCLDVLLA LTKRVLGKDL SMEKVLSEME SGFTLANTFK
     ITYEPITTTL KRKQEVVSAT IIQRAYKSYR LRQNDKNTSD THMIDGDREV QAIKEDSYID
     KAEGVSIIQS PI
//
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