ID W5P2Z5_SHEEP Unreviewed; 1692 AA.
AC W5P2Z5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN Name=SCN7A {ECO:0000313|Ensembl:ENSOARP00000004795.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000004795.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000004795.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000004795.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000004795.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR EMBL; AMGL01052904; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9940.ENSOARP00000004795; -.
DR PaxDb; 9940-ENSOARP00000004795; -.
DR Ensembl; ENSOART00000004876.1; ENSOARP00000004795.1; ENSOARG00000004467.1.
DR eggNOG; KOG2301; Eukaryota.
DR HOGENOM; CLU_000540_5_0_1; -.
DR OMA; ENSWFKC; -.
DR Proteomes; UP000002356; Chromosome 2.
DR Bgee; ENSOARG00000004467; Expressed in cardiac muscle tissue of left auricle and 27 other cell types or tissues.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF14; SODIUM CHANNEL PROTEIN; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 246..268
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 378..404
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 516..534
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 546..566
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 586..605
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 641..659
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 718..741
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 981..999
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1011..1028
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1070..1092
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1178..1205
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1262..1280
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1292..1314
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1326..1350
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1389..1415
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1427..1446
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1483..1509
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 133..412
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 515..740
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 755..938
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 945..1210
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1261..1510
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 812..882
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 813..827
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 828..852
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 856..875
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1692 AA; 194798 MW; 12DC23C8B1CF6661 CRC64;
MASPEPKSLV PFTRESLEVM EQHSAKKPSE EDKEDLKPNC DLEVGKELPF VYGNLPQAMV
SEPLEDVDPY YTNKRTFIVL NKKRTIFRFS ATWCTLSPFN SIRRATIKIL VHPYPFLLVL
NCTNIKCNNS IQILLHVLTD CIFMSMTDCP KWGPAFQNTL LGIYTFEILV KLIARGIWAG
PFYFFGDSWN WLDFSVTLFE HISRYSPLNF ISVFRIVRNL RILKIIPLNQ GMKSFVAILI
HCLKKLTVVI ILTVFFLSVF SLIGMGLFMG NLKHKCLRWP QENETDMLNN RTGNPYYIRE
TENFYYLEGE RYALLCGNRS DASQCPEGYV CVKAGVNPDD GYTNFDSFGW ALLALFRLMT
QDYPEALYHQ ILYASGKVYM IFFVVISFWF AFYMASLFLG LLAISYEEEK QTAAEKATVD
QEFQKSLPEL QEEKITAETK TIQLEMKKRS SPSMITSLDA LDDATVSHKE VSELKKSRQR
CPFCWYRFAK TFLIWDCSPC WLKLKEFVYR IIMDPFTDLF LTICIILNIN FLALEHYPMS
LETSNILSIG NMVFIGIFTT EMIFKIIAMH PYGYFQVGWN IYDSLIVFHG LAELYLTNFH
GLAILRSFRV LRIFRLGRYW PTFKILMLTL CNSVVALKDL VLLLFTFMFF SAVVGLNLYG
SNYKQYVCNI NEDCQLPHWH MCDFFHSFLN VFRILCGEWI ETLWDCFKVA GQFSCIPFYM
MVILIGKLLI LYLFLALIIS FSSYKPATTD EENDEAKNLQ RAMARIKKGI NYVLSKILCK
KQNVLKETMD NISDVYVKEN ISGHTLSELS NTQDFLKDKE KSSGTEKNTM TENESRSLIP
SPSVSETVPI ASEESDIENP DNKEIQNKSG DGSSKEKVKQ SSSSECSTVD IVLSEEEMVY
EREKPKHLRN VYERRSSSAQ IGRGPKKGKI WQNIRKTCCK IVENSCFKCF IGLVTLLSTG
ALAFEDIYID QRKTIKILLE YADMIFTYIF ILEMLLKWMA YGFKAYFTND WYKLDFMVVI
VFCLSLIGKS REELKPLVSI KFLRALRVLS QFEKMKVVVS ALIKTTLPTL SVFLVCLMIW
LAFGIIGVHL FAGKFYECID PTSGERFPLS EVMNRSQCET LVFNESMPWE NAKLNFDNVG
ISFLSLLQVA TFNGWITIMN SAVDSTDVDM QPHFENNIYM YCYFIDFIII GLFLPLSMLI
GAIVANFHKH KIKGGSNIFI TVKQKKQYRA LKKLMYEDSQ KPVPLPENKF QRFIFDLVTS
RVFNIIIMTL ICFQAITIMI QSDEQSPKID TALFWINSVY VGLYIGECVL KLIVFHCNYF
TSGWNIFDFM VVVFSITGLF LPLMVGYYLV SPSLVQLILL SRIIHILHPE KGLKLFHNLL
LPLMLSLPAL LNISLLIFLI MFIYAIFGMY NFAYVKKEAG IDDMSNFETF GSSMLCLFRV
TIFAGWDGML NAIFNSKWSD CDPDKINPGT QVRGDCGNPF LGIIYFVSYI LLTRLIIVNM
YIVVVMEFLN IASKKKAKTL SEEDFRKFFQ VWKRFDPDRT QYIDSSKLSD FAAALDPPLF
MAKPNKGQLV SMDLPMAVGD RIHCLDVLLA LTKRVLGKDL SMEKVLSEME SGFTLANTFK
ITYEPITTTL KRKQEVVSAT IIQRAYKSYR LRQNDKNTSD THMIDGDREV QAIKEDSYID
KAEGVSIIQS PI
//
