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Database: UniProt
Entry: W5P3L1_SHEEP
LinkDB: W5P3L1_SHEEP
Original site: W5P3L1_SHEEP 
ID   W5P3L1_SHEEP            Unreviewed;      1858 AA.
AC   W5P3L1;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   25-OCT-2017, entry version 27.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN9A {ECO:0000313|Ensembl:ENSOARP00000005013};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000005013, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000005013, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000005013};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000005013}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOARP00000005013}.
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DR   EMBL; AMGL01052908; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01052909; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01052910; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSOART00000005098; ENSOARP00000005013; ENSOARG00000004675.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000002356; Chromosome 2.
DR   ExpressionAtlas; W5P3L1; baseline.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0048266; P:behavioral response to pain; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   InterPro; IPR028803; SCN9A.
DR   PANTHER; PTHR10037:SF221; PTHR10037:SF221; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18   1858       Sodium channel protein. {ECO:0000256|SAM:
FT                                SignalP}.
FT                                /FTId=PRO_5004868716.
FT   TRANSMEM     61     80       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     92    113       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    119    138       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    209    228       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    248    275       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    607    633       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    645    663       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    725    753       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    815    838       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1063   1081       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1102   1118       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1130   1150       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1179   1205       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1303   1327       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1386   1404       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1416   1434       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1441   1466       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1503   1531       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1607   1630       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN        1    281       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      354    564       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      615    843       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      852   1057       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1061   1336       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1385   1640       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      272    310       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1858 AA;  211650 MW;  D065D01947B4562D CRC64;
     MLIMCTILTN CIFMTMSNPP DWTKNVEYTF TGIYTFESLV KILARGFCVG EFTFLRDPWN
     WLDFIVIVFA YLTEFVNLGN VSALRTFRVL RALKTISVIP GLKTIVGALI QSVKKLSDVM
     ILTVFCLSVF ALIGLQLFMG NLKHKCVQTS LANNETIEDI LNALDEEEYA KYFYYLEGSK
     DALLCGFSTD SGQCPEGYTC KKIGRNPDYG YTSFDTFSWA FLALFRLMTQ DYWENLYQQT
     LRAAGKTYMI FFVVVIFLGS FYLINLILAV VAMAYEEQNQ ANIEEARQKE LEFQQMLDRL
     KKEQEEAEAI ALAAAEYTSI GRSRIMGLSE SSSETSKLSS KSAKERRNRR RKKNQKKLSS
     GEEKGDDEKL SKSESEESIR RKSFHLGVEG HRRAREKRLS TPNQSPLSIR GSLFSARRSS
     RTSLFSFKGR GRDIGSETEF ADDEHSIFGD NESRRGSLFV PHRPRERRSS NISQASRSPP
     VLPVNGKMHS AVDCNGVVSL VDGPSALMLP NGQLLPEVII DKATSDDSGT TNQIYKKRRH
     SSYLLSEDML NDPNLRQRAM SRASILTNTV EELEESRQKC PPWWYRFAHT FLIWNCSPYW
     IKFKKFIYFI VMDPFVDLAI TICIVLNTLF MAMEHHPMTE EFKNVLVVGN LVFTGIFAAE
     MVLKLIAMDP YEYFQIGWNI FDSLIVTLSL VELFLSDVEG LSVLRSFRLL RVFKLAKSWP
     TLNMLIKIIG NSVGALGNLT LVLAIIVFIF AVVGMQLFGK SYKECVCKIN EDCKLPRWHM
     NDFFHSFLIV FRVLCGEWIE TMWDCMEVAG QAMCLIVYMM VMVIGNLVVL NLFLALLLSS
     FSSDNLTAIE EDTDANNLQI AVARIKTGIN YVKQTLREFV LKAFSKKPKI SKEIRQTEDL
     NCKKENYISN RTLAEMSKDH NFHKEKDKTS GFGNNMDKYL MEESDGQSFI HNPSLTVTVP
     IAPGESDLEI MNTEELSSDS DSEYSKGRLN QSSSSECSTV DNPVPGEGEE AEAEPVNSDE
     PEACFTDGCV QRFPCCQVNI ESGKGKIWWN IRKTCFRIVE HSWFESFIVL MILLSSGALA
     FEDIYIEKKK TIKIILEYAD KIFTYIFILE MLLKWVAYGY KTYFTNAWCW LDFLIVDVSL
     VTLVANTLGY SDLGPIKSLR TLRALRPLRA LSRFEGMRVV VNALIGAIPS IMNVLLVCLI
     FWLIFSIMGV NLFAGKFYEC INTTNGLRFP TNEVENRSAC LALMNVSQNV RWKNLKVNFD
     NVGLGYLSLL QVATFKGWMD IMYAAVDSVN VDKQPIYEYS LYMYIYFVIF IIFGSFFTLN
     LFIGVIIDNF NQQKKKLGGQ DIFMTEEQKK YYNAMKKLGS KKPQKPIPRP GNKFQGCIFD
     LVTNQAFDIA IMVLICLNMV TMMVEKEGQS EYMTEVLYWI NVVFIILFSG ECVLKLISLR
     CYYFTVGWNI FDFVVVILSI VGMFLADLIE RYFVSPTLFR VIRLARIGRI LRLIKGAKGI
     RTLLFALMMS LPALFNIGLL LFLVMFIYAI FGMSNFAYVK KEAGINDMFN FETFGNSMIC
     LFQITTSAGW DGLLAPILNS APPDCDPKKV HPGSSVEGDC GNPSVGIFYF VSYIIISFLV
     VVNMYIAVIL ENFSVATEES TEPLSEDDFE MFYEVWEKFD PDATQFIEYS KLSDFAAALD
     PPLLIAKPNK VQLIAMDLPM VSGDRIHCLD ILFAFTKRVL GEGGEMDSLR SQMEERFMSA
     NPSKVSYEPI TTTLKRKQED VSATVIQRAY RRYRLRQHVK NISSIYIKDG DRDDDLPNKE
     HMVFDNVNEN SSPEKTDATP STVSPPSYDS VTKPDREKYE KDKTEKEDKG KDGKEGKK
//
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