ID W5P4N3_SHEEP Unreviewed; 1316 AA.
AC W5P4N3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Tetratricopeptide repeat protein 21B {ECO:0008006|Google:ProtNLM};
GN Name=TTC21B {ECO:0000313|Ensembl:ENSOARP00000005386.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000005386.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000005386.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000005386.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000005386.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TTC21 family.
CC {ECO:0000256|ARBA:ARBA00010935}.
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DR EMBL; AMGL01052917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01052918; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01052919; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01052920; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004004687.1; XM_004004638.3.
DR STRING; 9940.ENSOARP00000005386; -.
DR PaxDb; 9940-ENSOARP00000005386; -.
DR Ensembl; ENSOART00000005473.1; ENSOARP00000005386.1; ENSOARG00000005011.1.
DR GeneID; 101102621; -.
DR KEGG; oas:101102621; -.
DR CTD; 79809; -.
DR eggNOG; ENOG502QQAB; Eukaryota.
DR HOGENOM; CLU_006149_0_0_1; -.
DR OMA; NATCVRA; -.
DR OrthoDB; 121960at2759; -.
DR Proteomes; UP000002356; Chromosome 2.
DR Bgee; ENSOARG00000005011; Expressed in embryo and 53 other cell types or tissues.
DR GO; GO:0005929; C:cilium; IEA:GOC.
DR GO; GO:0030991; C:intraciliary transport particle A; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0060020; P:Bergmann glial cell differentiation; IEA:Ensembl.
DR GO; GO:0021702; P:cerebellar Purkinje cell differentiation; IEA:Ensembl.
DR GO; GO:0021798; P:forebrain dorsal/ventral pattern formation; IEA:Ensembl.
DR GO; GO:0035721; P:intraciliary retrograde transport; IEA:Ensembl.
DR GO; GO:1903999; P:negative regulation of eating behavior; IEA:Ensembl.
DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0097499; P:protein localization to non-motile cilium; IEA:Ensembl.
DR GO; GO:1905799; P:regulation of intraciliary retrograde transport; IEA:Ensembl.
DR GO; GO:0008589; P:regulation of smoothened signaling pathway; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl.
DR GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 6.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR040364; TTC21A/TTC21B.
DR PANTHER; PTHR14699; STI2 PROTEIN-RELATED; 1.
DR PANTHER; PTHR14699:SF1; TETRATRICOPEPTIDE REPEAT PROTEIN 21B; 1.
DR Pfam; PF13432; TPR_16; 1.
DR Pfam; PF13181; TPR_8; 2.
DR SMART; SM00028; TPR; 18.
DR SUPFAM; SSF81901; HCP-like; 1.
DR SUPFAM; SSF48452; TPR-like; 5.
DR PROSITE; PS50005; TPR; 3.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 324..357
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 722..755
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 952..985
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 1316 AA; 151161 MW; CCE64ACEBABF50C7 CRC64;
MDSQGLKALI NYYCQERYFH HVLLVASEGM KSYGSDPVFR FYHAYATLME GKIQEALREF
EAIKNKQDVS LCSLIALIYA HKMSPNPDRE AILESDARVK EQRKGAGPKV LYHAGLFLWH
IGRHDKAREY IDRMIKISNG SKEGQVLRAW LDITRRKEPY TKKALRYFEE GLQDGNDIFA
LLGKAQCLEM RQNYSGALET VNQIIMNFPG FLPAFVKKMK LQLALQDWDQ TVETAQRLML
QDNQNLEALR MLALYYLCRE GDIEKAATQL ENLGNALDAV EPQNAQLFYT ITIAFSRICG
RSQLILQKTQ TLLERAFSLN PQQSEFATEL GYQMILHGKV KEALKWYKTA MTLDETSVSA
LIGFIQCQLI EGQLQDADQH LEFLREVQQS IGKSAELTYL HAVLAMRKNK RQEEVINLLN
DVLDTHFSQL EDLPLGIQYF EKLNPDFLIE IITEYLNFCP MQPASPGQPL SPLLRRCTSI
LETIVRTVPG LLQAVFLIAK VKYLSGDIEA AYNNLQHCLE HSPSYADAHL LMAQVYLSQE
KFKLCSQSLE LCLSYNFKVR EYPLYHLIKA QSQKKMGEIA EAIKTLHMAM SLPGMRRIGS
SSKTKYRKTE VDASHRLSVF LELAEVHRLN GEQHEAAKVL QDAIHEFSGT SEELRVTIAN
ADLALAQGDV ERALSMLQNV TAEQPYFIEA KEKMADIYLK HRKEKMLYIT CYREMAERMP
SPRSFLLLGD AYMNIQEPEE AIVAYEQALN HNPKDGTLAS KIGKALVKTH NYSKAITYYE
AALKSGQQNY LCYDLAELLL KLKWYDKAEK VLQHALAHEP VNELSALMED GRFQVLLAKV
YSKVDRPDDA VTSLQQAREL QARVLKRVQM EQPDAVPAQK HLAAEICAEI AKHSVAQRNY
EKAIKFYREA LVHCETDNKI MLELARLYLL QDDPDACLRH CALLLQNDQD NEAATMMMAD
LMFRKQDYEQ AVFHLQQLLE RKPDNYMTLS RLIDFLRRCG KLEDVPRFFL MAEKRNSRAK
LEPGFQYCKG LYLWYTGEPN DALRHFNKAR KDSDWGQNAL YNMIEICLNP DNETVGGEVF
ENLDADPGNS TEKQESVQLA VRTAEKLLKE LKPQTVQGQV QLRIMENYCL MATKQKSNVE
QALNTFTEIA ASEKDHVPAL LGMATAHMIL KQTPRARNQL KRIAKMNWNP IDAEDFERSW
LLLADIYIQS AKYDMAEELI KRCLRHNRSC CKAYEYMGYI MEKEQAYMDA ALNYEMAWKH
GNQTNPAVGY KLAFNYLKAK RYVDAIDVCH QVLEAHPTYP KIRKDILDKA RTSLRP
//
