GenomeNet

Database: UniProt
Entry: W5P4Z6_SHEEP
LinkDB: W5P4Z6_SHEEP
Original site: W5P4Z6_SHEEP 
ID   W5P4Z6_SHEEP            Unreviewed;      1085 AA.
AC   W5P4Z6;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   25-OCT-2017, entry version 29.
DE   SubName: Full=Transient receptor potential cation channel subfamily A member 1 {ECO:0000313|Ensembl:ENSOARP00000005499};
GN   Name=TRPA1 {ECO:0000313|Ensembl:ENSOARP00000005499};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000005499, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000005499, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000005499};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000005499}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00933551}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOARP00000005499}.
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DR   EMBL; AMGL01111487; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01111488; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01111489; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01111490; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSOART00000005586; ENSOARP00000005499; ENSOARG00000005124.
DR   GeneTree; ENSGT00900000140877; -.
DR   Proteomes; UP000002356; Chromosome 9.
DR   ExpressionAtlas; W5P4Z6; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   CDD; cd00204; ANK; 4.
DR   Gene3D; 1.25.40.20; -; 6.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR030288; TRPA1/painless.
DR   PANTHER; PTHR24190; PTHR24190; 1.
DR   Pfam; PF12796; Ank_2; 6.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 15.
DR   SUPFAM; SSF48403; SSF48403; 2.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 9.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023,
KW   ECO:0000256|SAAS:SAAS00933366};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Ion channel {ECO:0000256|SAAS:SAAS00931870};
KW   Ion transport {ECO:0000256|SAAS:SAAS00929079};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Repeat {ECO:0000256|SAAS:SAAS00931009};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00927442}.
FT   TRANSMEM    773    791       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    797    817       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    837    859       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    905    932       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       28    545       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   REPEAT       63     95       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      130    162       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      204    236       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      274    306       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      307    339       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      378    410       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      411    443       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      447    472       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      513    545       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
SQ   SEQUENCE   1085 AA;  123127 MW;  1EDBD4F829E07EAC CRC64;
     FKVVFEGNKC GLQNFVKKHK RLKKYDDVNA SPLHHAAEEG QVELMEMIVN ESSCEVLNVM
     DDYGNTPLHW AAGKNQVESV KFLLRKGANP NLRNCSMMAP LHVAVQGGYN DVMKVLIEHS
     STDVNLEGEN GNTALIITCF TDNSEAMQLL LNKGAKPCKS NKWGCFPIHQ AAFSGAKKCM
     EIILKFGEEH GYSRLCHINF VNSGKASPLH MAVQSGDLDM IKMCLDNGAQ LDLLEKGKCT
     ALHFAATQGA TEIVKLMVSS YSGSSDIVNE VDGNHETLLH RASLFDHHEL ADYLISVGAD
     IDITDSEGRS PLLLATASAS WNTVNLLLSK GARVDIKDNL GRNFLHLTVQ QPYGLKNLHP
     EFLQMQHIKE LVMDEDNDGC TPLHYACRQG VPVSVNNLLN FNVSIHSKSK DKKSPLHFAA
     SYGRINTCQR LLQDISDTRL LNEGDLHGMT PLHLAAKNGH DKVVQLLLKK GALFLSDHSG
     WTALHHASLG GYTQTMKVIL DTNLKCTDRL DEEGNTALHF AAREGHAKAV SLLLSYDADV
     VLNKQQASFL HVAIHNKRKE VVLTTIRNKR WGECFKVFNH CSPTNRCPVI ELVEYLPECM
     KVLLDFCVMP STEDKSSQDY HIEYNFTYLQ CPLEFTKKGT PVQDVVYEPL LTLNAMVQHN
     RIELLNHPVC KEYLLMKWLA YGFRAHVLNL GSYCLGLFPM TFLVVSIRPG MAFNSTGIIN
     ETSDHSEILD TKNSYAINFC MILVLLSSIL GYCKEVAQIF QQKRNYFLDK DNAAEWIIYT
     TSIIFVSPLF IRIPAYVQWQ CGAVAIFLYW MNFLLYLQRF EKCGIFIVML EVIMKTLLKS
     TIVFVFLLVA FGLCFYVLLN FQDAFSSPFL SIMQTFSMML GDINYHDAFL EPYLKDELEY
     PLLSFVHLIT FTMFVPIVLM NLLIGLAVGD IAEVQKHALL KRIAMQVELH TSLEKKLPLW
     FLHKVDQKSI IVYPNRPRYS RGILRGVFHY IFCPHETRQE IPNVDTSLET EIMKQKYRLK
     DLGSLLEKQH ELIKLIIQKM EIISETEDED YHSSFQDRFK KQQLEQRNSK WNCVLRAVKA
     KTHSP
//
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