ID W5P536_SHEEP Unreviewed; 602 AA.
AC W5P536;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Cdc42-interacting protein 4 {ECO:0008006|Google:ProtNLM};
GN Name=TRIP10 {ECO:0000313|Ensembl:ENSOARP00000005539.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000005539.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000005539.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000005539.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000005539.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex
CC {ECO:0000256|ARBA:ARBA00004544}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Lysosome
CC {ECO:0000256|ARBA:ARBA00004371}.
CC -!- SIMILARITY: Belongs to the FNBP1 family.
CC {ECO:0000256|ARBA:ARBA00009426}.
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DR EMBL; AMGL01091473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01091474; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5P536; -.
DR SMR; W5P536; -.
DR STRING; 9940.ENSOARP00000005539; -.
DR PaxDb; 9940-ENSOARP00000005539; -.
DR Ensembl; ENSOART00000005626.1; ENSOARP00000005539.1; ENSOARG00000005162.1.
DR eggNOG; KOG3565; Eukaryota.
DR HOGENOM; CLU_023320_1_0_1; -.
DR OMA; CVAIYQF; -.
DR Proteomes; UP000002356; Chromosome 5.
DR Bgee; ENSOARG00000005162; Expressed in vas deferens and 52 other cell types or tissues.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd07653; F-BAR_CIP4-like; 1.
DR CDD; cd11628; HR1_CIP4_FNBP1L; 1.
DR CDD; cd11911; SH3_CIP4-like; 1.
DR Gene3D; 6.10.140.470; -; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR011072; HR1_rho-bd.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15735:SF17; CDC42-INTERACTING PROTEIN 4; 1.
DR PANTHER; PTHR15735; FCH AND DOUBLE SH3 DOMAINS PROTEIN; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS51860; REM_1; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..264
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 392..469
FT /note="REM-1"
FT /evidence="ECO:0000259|PROSITE:PS51860"
FT DOMAIN 541..602
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 168..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 477..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 396..473
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 168..186
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..352
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 497..513
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 602 AA; 68631 MW; 2BAAFC4D30D722F6 CRC64;
MDWGTELWDQ FEVLERHTQW GLDLLDRYVK FVKERTEVEQ AYAKQLRSLV KKYMPKRPAK
DDPESKFSQQ QSFVQILQEV NDFAGQRELV AENLSVRVCL ELAKYSQEMK QERKMHFQEG
RRAQQQLESG FKQLENSKRK FERDCREAEK AAQTAERLDQ DINATKADVE KAKQQAHLRS
HMAEESKNEY AAQLQRFNRD QSHFYFSQMP QIFDKLQDMD ERRATHLGAG YGLLSETELE
VVPIIAKCLE GMKVAADAVN AKNDSQVLIE LHKSGFARPG DVEFEDFSQP MNRVPSDSSL
GTPSDGVRLR EETCFRVWGW KLDIRCKPCP PPLSPRGGPL PSALPNGPPS PRSGLDPLAI
LSEISKSVKP RLASFRSLRG SRGTVVTEDF SHLPPEQQRK RLQQQLEERN RELQKEMDQR
EALKKMKDVY EKTPQMGDPA SLEPRITETL NNIERLKLEV QKYEAWLAEA ESRVLSNRGD
TLGRHTRPPD PPASAPPDSS SNSNNGSQEN KESSAEPPSE EGQDAPIYTE FDEEFEEEPA
SPIGHCVAIY HFEGSSEGTI SMAEGEDLSL MEEDKGDGWT RVRRKQGGEG YVPTSYLRVM
LN
//
