ID W5P5D7_SHEEP Unreviewed; 535 AA.
AC W5P5D7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000005640.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000005640.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000005640.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000005640.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000005640.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=heme b; Xref=ChEBI:CHEBI:60344;
CC Evidence={ECO:0000256|ARBA:ARBA00001970};
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DR EMBL; AMGL01046591; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01046592; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01046593; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01046594; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01046595; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01046596; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01046597; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5P5D7; -.
DR SMR; W5P5D7; -.
DR PaxDb; 9940-ENSOARP00000005640; -.
DR Ensembl; ENSOART00000005728.1; ENSOARP00000005640.1; ENSOARG00000005250.1.
DR eggNOG; KOG2408; Eukaryota.
DR HOGENOM; CLU_509580_0_0_1; -.
DR Proteomes; UP000002356; Chromosome 2.
DR Bgee; ENSOARG00000005250; Expressed in thyroid gland and 31 other cell types or tissues.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0004601; F:peroxidase activity; IEA:InterPro.
DR GO; GO:0006082; P:organic acid metabolic process; IEA:UniProt.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 1.
DR InterPro; IPR019791; Haem_peroxidase_animal.
DR InterPro; IPR010255; Haem_peroxidase_sf.
DR InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR PANTHER; PTHR11475; OXIDASE/PEROXIDASE; 1.
DR PANTHER; PTHR11475:SF60; THYROID PEROXIDASE; 1.
DR Pfam; PF03098; An_peroxidase; 1.
DR SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR PROSITE; PS50292; PEROXIDASE_3; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT REGION 245..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 285..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 535 AA; 57997 MW; 9652B39FF5783847 CRC64;
MRARAVLGAV LAVTCAGAIF SFLLRPGGLL WGDTEESQVR GIVEASRLLV DESIYAAMRR
NLHKREVISP SQLLSFSKLP EPTSRAASRA AEVMEASVQE AVRRGHLQSG PSRLPTDALS
EGLLSAIANL SGCLPHMLPP RCPATCLVSK YRLITGACNN RYLLGPPHPQ IGFKLRHRSQ
RSPAPRQTGT TATRMLAVKL PGLPVATPVS SRLSLCVSAI HSQLAPSGGL LSCWGHCAEE
EAQRLSGSGA RERGAGAQTD PDGGDTCLPV KLPSRDVSPR CLSALRPSPL MKRGPKASPF
SGAREQRRVD ARIHAHSLSF RQKGASLLSA GLGGSHRRKV WSHGRPRLKQ ALRDGQTVLN
AWLLSLSGRT QGRHIHIRTM ALKALKTVSS LPSSCSLHCL DVLSACTADA ESLAQRSPAH
PQTPASLLSF WETLSPPTTQ MAITAPLFAC LVGKQMKALR DGDRFWWEHH GVFTEAQRRE
LGRHSLSRVI CDNTGLTHVP RDAFRVGQWP QDFESCDRIP GMDLRAWREA PPPGN
//
