ID W5P5T6_SHEEP Unreviewed; 147 AA.
AC W5P5T6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Protein phosphatase 1 regulatory subunit 14 {ECO:0000256|RuleBase:RU369059};
GN Name=PPP1R14B {ECO:0000313|Ensembl:ENSOARP00000005789.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000005789.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000005789.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000005789.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000005789.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Inhibitor of PPP1CA. {ECO:0000256|RuleBase:RU369059}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU369059}.
CC -!- SIMILARITY: Belongs to the PP1 inhibitor family.
CC {ECO:0000256|ARBA:ARBA00005483, ECO:0000256|RuleBase:RU369059}.
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DR EMBL; AMGL01061771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01061772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5P5T6; -.
DR PaxDb; 9940-ENSOARP00000005789; -.
DR Ensembl; ENSOART00000005877.1; ENSOARP00000005789.1; ENSOARG00000005394.1.
DR eggNOG; KOG0824; Eukaryota.
DR HOGENOM; CLU_114155_1_0_1; -.
DR OMA; DMDSDEH; -.
DR Proteomes; UP000002356; Chromosome 21.
DR Bgee; ENSOARG00000005394; Expressed in longissimus thoracis muscle and 52 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0042325; P:regulation of phosphorylation; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.150.220; CPI-17; 1.
DR InterPro; IPR008025; CPI-17.
DR InterPro; IPR036658; CPI-17_sf.
DR PANTHER; PTHR16188; PROTEIN PHOSPHATASE 1 INHIBITOR POTENTIATED BY PROTEIN KINASE C; 1.
DR PANTHER; PTHR16188:SF5; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 14B; 1.
DR Pfam; PF05361; PP1_inhibitor; 1.
DR SUPFAM; SSF81790; Myosin phosphatase inhibitor 17kDa protein, CPI-17; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|RuleBase:RU369059};
KW Phosphoprotein {ECO:0000256|RuleBase:RU369059};
KW Protein phosphatase inhibitor {ECO:0000256|ARBA:ARBA00023272,
KW ECO:0000256|RuleBase:RU369059};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 62..103
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 8..22
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 147 AA; 16192 MW; E4889AE8317C4BC5 CRC64;
SAHSPPFSGG PCFPPAPGPG SGGPGPRVYF QNPPGAAGEG PGGADDEGPV RRQGKVTVKY
DRKELRKRLN LEEWILEQLT RLYDCQEEEI PELEIDVDEL LDMESDDTRA ARVKELLVDC
YKPTEAFISG LLDKIRGMQK LSTPQKK
//
