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Database: UniProt
Entry: W5P6U4_SHEEP
LinkDB: W5P6U4_SHEEP
Original site: W5P6U4_SHEEP 
ID   W5P6U4_SHEEP            Unreviewed;      4903 AA.
AC   W5P6U4;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   25-OCT-2017, entry version 27.
DE   SubName: Full=Ryanodine receptor 1 {ECO:0000313|Ensembl:ENSOARP00000006148};
GN   Name=RYR1 {ECO:0000313|Ensembl:ENSOARP00000006148};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000006148, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000006148, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000006148};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000006148}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOARP00000006148}.
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DR   EMBL; AMGL01028799; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01028800; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01028801; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01028802; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01028803; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01028804; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSOART00000006242; ENSOARP00000006148; ENSOARG00000005704.
DR   GeneTree; ENSGT00760000119152; -.
DR   OMA; DIPARRN; -.
DR   OrthoDB; EOG091G00T0; -.
DR   Proteomes; UP000002356; Chromosome 14.
DR   GO; GO:0005938; C:cell cortex; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0031674; C:I band; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030314; C:junctional membrane complex; IEA:Ensembl.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0030315; C:T-tubule; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IEA:Ensembl.
DR   GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0071313; P:cellular response to caffeine; IEA:Ensembl.
DR   GO; GO:0006936; P:muscle contraction; IEA:Ensembl.
DR   GO; GO:0043931; P:ossification involved in bone maturation; IEA:Ensembl.
DR   GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
DR   GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0048741; P:skeletal muscle fiber development; IEA:Ensembl.
DR   GO; GO:0043588; P:skin development; IEA:Ensembl.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR033215; RyR1.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   PANTHER; PTHR13715:SF15; PTHR13715:SF15; 2.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4426   4446       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4703   4725       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4784   4807       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       98    153       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      160    205       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      211    265       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      271    334       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      336    393       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      582    798       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1014   1208       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1357   1570       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     1872   1928       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4903 AA;  551484 MW;  26A685C3A26C01E0 CRC64;
     MGDGGEGEDE VQFLRTFFEV IGLCRLGLIK AWLKLKLKID SRGRLLLVVS HKSTARNVPP
     DLAICCFVLE QSLSVRALQE MLANTVEAGV ESSQGGGHRT LLYGHAILLR HAHSGMYLSC
     LTTSRSMTDK LAFDVGLQED AIGEACWWTT HPASKQRSEG EKVRVGDDLI LVSVSSERYL
     HLSTASGELQ VDASFMQTLW NMNPICSGCE EGYVTGGHVL RLFHGHMDEC LTISPADSED
     QRRLVYYEGG SVCTHARSLW RLEPLRISWS GSHLGWGQPL RIRHVTTGRY LALVEDQGLV
     VVDASKAHTK ATSFCFRISK EKLDTAPKRD VEGMGPPEIK YGESLCFVQH VASGLWLTYA
     APDPKALRLG VLKKKAILHQ EGHMDDALSL TRCQHEESQA ARMIYSTAGL YNHFIKERDS
     FSGKPRGSGS PAGTALPLEG VILSLQDLIG YFEPPSEELQ HEEKQSKLRS LRNRQSLFQE
     EGMLSLVLNC IDRLNVYTTA AHFAEFAGEE AAESWKEIVN LLYEILASLI RGNRANCALF
     SNNLDWLVSK LDRLEASSGI LEVLYCVLIE SPEVLNIIQE NHIKSIISLL DKHGRNHKVL
     DVLCSLCVCN GVAVRSNQDL ITENLLPGRE LLLQTNLINY VTSIRPNIFV GRAEGTTQYL
     KWYFEVMVDE VVPFLTAQAT HLRVGWALTE GYSPYPGGGE GWGGNGVGDD LYSYGFDGLH
     LWTGHVPRLV TSPGQHLLAP EDVVSCCLDL SVPSISFRIN GCPVQGVFEA FNLDGLFFPV
     VSFSAGVKVR FLLGGRHGEF KFLPPPGYAP CHEAVLPRER LHLEPIKEYR REGPRGPPWG
     APSRCLSHND FVPCPVDTVQ IVLPPHLERI REKLAENIHE LWALTRIEQG WTYGPVRDDN
     KRLHPCLVDF HSLPEPERNY NLQMSGETLK TLLALGCHVG MADEKAEDNL KKTKLPKTTL
     MSNGHDEQRL DLSHVRLTPA QTTLVDRLAE NGHNVWARDR VAQGWSYSAV QDIPARRNPR
     LVPYRLLDEA TKRSNRDSLC QAVRTLLGYG YNIEPPDQEP SQVESQSRWD RVRIFRAEKS
     YVVQSGRWYF EFEAVTTGEM RVGWARPELR PDVELGADDL SYVFNGHRGQ RWHLGSEPFG
     RPWQSGDVVG CMIDLTENTI ISCILPMAAP AAHVSSPLPI YPLPPGFLPV CSLGPGQVGH
     LNLGQDVSSL RFFAICGLQE GFEPFAINMQ RPVTTWFSKG LPQFEAVPPE HPHYEVTRVD
     GTVDTPPCLR LTHRTWGSQN SLVEMLFLRL SLPVQFHQHF RCTAGATPLA PPGLQPPAED
     EARAAEPDPD YENLRRSAGH WAEAEGNKEG TAKEGTPGGP AQAGVEAQPA RAENEKDATT
     EKNKKRGFLF KAKKAAMMTQ PPATPTLPRL PHEVVPADDR DDPEIILNTT TYYYSVRVFA
     GQEPSCVWVG WVTPDYHQHD MNFDLSKVRA VTVTMGDEQG NIHSSLKCSN CYMVWGGDFL
     SPGQQGRISH TDLVIGCLVD LATGLMTFTA NGKESNTFFQ VEPNTKLFPA VFVLPTHQNV
     IQFELGKQKN IMPLSAAMFL SERKNPTPQC PPRLEMQMLM PVSWSRMPNH FLQVETRRAA
     GERLGWAVQC QEPLTMMALH IPEENRCMDI LELSERLDLQ RFHSHTLCLY RAVCALGNNR
     VAHALCSHVD QAQLLHALED AHLPGPLRAG YYDLLISIHL ESACRSRRSM LSEYIVPLTP
     ETRAITLFPP GKRADNGPRR HGLPGVGVTT SLRPPHHFSA PCFVAALPAA RAGEPPARLS
     PSIPLEALRD KALRMLGEAV RDGGQHARDP VGGSVEFQFV PVLKLVSTLL VMGIFGDEDV
     KQILKMIEPE VFTEEEEEEE EDEEEGEEEE EDEEEKEEDE EEEAREKEDE EKEEEETAEG
     EKEDLEEGLL QMKLPESVKL QMCNLLEYFC DQELQHRVES LAAFAERYVD KLQANQRDRY
     AILMKAFTMT AAETARRTRE FRSPPQEQIN MLLHFKTAED EEECPLPEEV RQDLLEFHQD
     LLTHCGIQLA GEEEEPEEEA TLGSRLMSLL EKVRLVKKKE EKSEEESPAK ERKPQSLQEL
     VSHTVVRWAQ EDFVQSPELV RAMFSLLHRQ YDGLGELLRA LPRAYTISPS SVEDTMSLLE
     CLGQIRSLLI VQMGPQEENL MIQSIGNIMN NKVFYQHPNL MRALGMHETV MEVMVNVLGG
     GESKEIRFPK MVTSCCRFLC YFCRISRQNQ RSMFDHLSYL LENSGIGLGM QGSTPLDVAA
     ASVIDNNELA LALQEQDLEK VVSYLAGCGL QSCPMLLAKG YPDIGWNPCG GERYLDFLRF
     AVFVNGEAGG GGNRGGGWGA SLVKPPLVGI GQGPEVNGGL EFTLEVPGES VEENANVPGV
     RRDRRREHFG EEPPEENRVH LGHAIMSFYA ALIDLLGRCA PEMHLIQAGK GEALRIRAIL
     RSLVPLDDLV GIISLPLQIP TLGKDGALVQ PKMSASFVPD HKASMVLFLD RVYGIENQDF
     LLHVLDVGFL PDMRAAASLD TATFSTTEMA LALNRYLCLA VLPLITKCAP LFAGTEHRAI
     MVDSMLHTVY RLSRGRSLTK AQRDVIEECL MALCAPAHGA MTASPVRVPA VPILNEFAKM
     PLKLLTNHYE RCWKYYCLPT GWANFGVTSE EELHLTRKLF WGIFDSLAHK KYDQELYRMA
     MPCLCAIAGA LPPDYVDASY SSKAEKKASV DAEGNFDPRP VETLNVIIPE KLDSFINKFA
     EYTHEKWAFD KIQNNWSYGE NIDEELKTHP MLRPYKTFSE KDKEIYRWPI KESLKAMIAW
     EWTIEKAREG EEEKTEKKKT RKISQSAQTY DAREGYNPQP PDLSGVTLSR ELQAMAEQLA
     ENYHNTWGRK KKQELEAKGG GTHPLLVPYD TLTAKEKARD REKAQELLKF LQMNGYAVTR
     GLKDMELDTS SIEKRFAFGF LQQLLRWMDI SQEFIAHLAE AVVSSGRVEK SPHEQEIKFF
     AKILLPLIKQ YFTNHCLYFL STPAKVLGSG GHASNKEKEM ITSLFCKLAA LVRHRVSLFG
     TDAPAVVNCL HILARSLDAR TVMKSGPEIV KAGLRSFFES ASEDIEKMVE NLRLGKVSQA
     RTQVKGVGQN LTYTTVALLP VLTTLFQHIA QHQFGDDVIL DDVQVSCYRT LCSIYSLGTT
     RNPYVEKLRP ALGECLARLA AAMPVAFLEP QLNEYNACSV YTTKSPRERA ILGLPNSVEE
     MCPDIPVLER LMADIGGLAE SGARYTEMPH VIEITLPMLC SYLPRWWERG PEAPPPALPA
     GAPPPCTAVT SDHLNSLLGN ILRIIVNNLG IDEATWMKRL AVFAQPIVSR ARPELLHSHF
     IPTIGRLRKR AGKVVAEEEQ LRLEGKAEAE EGELLVRDEF SVLCRDLYAL YPLLIRYVDN
     NRAHWLTEPN PSAEELFRMV GEIFIYWSKS HNFKREEQNF VVQNEINNMS FLTADNKSKM
     AKSGGSDQER TKKKRRGDRY SVQTSLIVAT LKKMLPIGLN MCAPTDQELI TLAKTRYALK
     DTDEEVREYL QNNLHLQGKV EGSPSLRWQM ALYRGLPGRE EDADDPEKIV RRVQEVSAVL
     YHLEQIEHPY KSKKAVWHKL LSKQRRRAVV ACFRMTPLYN LPTHRACNMF LESYKAAWIL
     TEDHSFEDRM IDDLSKAGEQ EEEEEEVEEK KPDPLHQLVL HFSRTALTEK SKLDEDYLYI
     AYADIMAKSC HLEEGGENGE AVEEEVEVSF EEKEMEKQRL LYQQARLHTR GAAEMVLQMI
     SACKGETGAM VSSTLKLGIS ILNGGNADVQ QKMLDYLKDK KEVGFFQSIQ ALMQTCSVLD
     LNAFERQNKA EGLGMVNEDG TVINRQNGEK VMADDEFTQD LFRFLQLLCE GHNNDFQNYL
     RTQTGNTTTI NIIICTVDYL LRLQESISDF YWYYSGKDVI EEQGKRNFSK AMSVAKQVFN
     SLTEYIQGPC TGNQQSLAHS RLWDAVVGFL HVFAHMMMKL AQDSSQIELL KELLDLQKDM
     VVMLLSLLEG NVVNGMIARQ MVDMLVESSS NVEMILKFFD MFLKLKDIVG SEAFQDYVTD
     PRGLISKKDF QKAMDSQKQF TGPEIQFLLS CSEADENEMI DCEEFANRFQ EPARDIGFNV
     AVLLTNLSEH VPHDPRLRNF LELAESILEY FRPYLGRIEI MGASRRIERI YFEISETNRA
     QWEMPQVKES KRQFIFDVVN EGGESEKMEL FVSFCEDTIF EMQIAAQISE PEGEPEEDED
     EGARAAEAVP PHRAGRAPPA AAEGAGDEEV ADQEDPGVAA GGWVGADGGP FRPEGAGLGD
     MGDTTPAEPP TPEGSPIIKR KLGVAGEEEE LPPEPEPEPE PQPEKADAEN GEKEEVPETP
     PEPPKKAVPP PPPPKKEGAG GAGLEFWGEL EVQRVKFLNY LSRNFYTLRF LALFLAFAIN
     FILLFYKVSD SPPGEDDMEG SAAGGLSGAG SGGGSGWGSG AGEEAEGDED ENMVYYFLEE
     STGYMEPALR CLSLLHTLVA FLCIIGYNCL KVPLVIFKRE KELARKLEFD GLYITEQPED
     DDVKGQWDRL VLNTPSFPSN YWDKFVKRKV LDKHGDIYGR ERIAELLGMD LATLEITAHN
     ERKPEPPPGL LTWLMSIDVK YQIWKFGVIF TDNSFLYLGW YMVMSLLGHY NNFFFAAHLL
     DIAMGVKTLR TILSSVTHNG KQLVMTVGLL AVVVYLYTVV AFNFFRKFYN KSEDEDEPDM
     KCDDMMTCYL FHMYVGVRAG GGIGDEIEDP AGDEYELYRV VFDITFFFFV IVILLAIIQG
     LIIDAFGELR DQQEQVKEDM ETKCFICGIG SDYFDTTPHG FETHTLEEHN LANYMFFLMY
     LINKDETEHT GQESYVWKMY QERCWDFFPA GDCFRKQYED QLS
//
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