ID W5P787_SHEEP Unreviewed; 2689 AA.
AC W5P787;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Neurobeachin like 2 {ECO:0008006|Google:ProtNLM};
GN Name=NBEAL2 {ECO:0000313|Ensembl:ENSOARP00000006291.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000006291.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000006291.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000006291.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000006291.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AMGL01045738; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01045739; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01045740; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01045741; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR SMR; W5P787; -.
DR STRING; 9940.ENSOARP00000006291; -.
DR PaxDb; 9940-ENSOARP00000006291; -.
DR Ensembl; ENSOART00000006387.1; ENSOARP00000006291.1; ENSOARG00000005857.1.
DR eggNOG; KOG1787; Eukaryota.
DR HOGENOM; CLU_000218_0_0_1; -.
DR OMA; SQVCEMA; -.
DR Proteomes; UP000002356; Chromosome 19.
DR Bgee; ENSOARG00000005857; Expressed in omasum and 52 other cell types or tissues.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046851; NBCH_WD40.
DR InterPro; IPR031570; NBEA/BDCP_DUF4704.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF111; NEUROBEACHIN-LIKE PROTEIN 2; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF15787; DUF4704; 1.
DR Pfam; PF16057; DUF4800; 1.
DR Pfam; PF20426; NBCH_WD40; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 1849..1974
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 1987..2279
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 2432..2473
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 2483..2524
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 769..793
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1264..1305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1323..1395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1265..1296
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1323..1346
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1362..1395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2689 AA; 295265 MW; 423846AC2586EB5D CRC64;
LGRGQALRLH MWCLRSWEKK DLGYLQQWLQ AFVGAFEKSI SLFSLEPRRP EEVGAEVPLL
PLDVLHVLAE QLDARDLEQA LLLLKLFIIL CRNPENVEAG WGRVLAPRVL ALLTQLVAEL
KGPPSPQEDR GPQLEIVALH ALLLCEGLFD PYQTWRRQHR GEVISAKEKS KYKFPPAALP
SEFSAFFRES LQDADRLPSV LLLRLIHLFG AVLAGGKENG QKAVSAGSVQ GLLGVVRGWG
HRPAQDPHLV PLALEVLVGA VHVLHASRAP PRGPELRALL EGYFRVLNTD WPAGPSPDPE
EAHVTLRVSM LDAIPMMLAC EDRPVLQATF LSNNCFEHLI RLIQNSKLYL QARAPPEGDS
DLATRLLTEP DVQKVLDQDT DAIAVHVVRV LTCIMSGSPS AKEVFKERIG YPHLHEVLQS
HGPPTHRLLQ ELLNMAVGGA HGMCPPPPIR NEQPVLVLMR WLPTLPTAEL RPFLAQRLWG
RCDRAPASRA PTEVLVGCLL ETLSEGVALG ARCQEQLLAL LQALGHVSLR PSELRRLLRP
PPGLDLGPGG AEAGQARHAG AIIRALSGMA RHQGPARALR YFDLTPSMAG IMVPPVQRWP
GPGFTFHAWL CLHPTAGAPA PAPTPTRRGL TGLAGPQLLH QQAAGTLVVA VCTRKEYLTM
SLPEVSFADS SWHCVAIVHV PGRRPFSQNL VHVYKDGHLV KMAPLRCPSL SEPFSSCCIG
SAGHRTTTTT TPPQPYPCSQ DPRGWVSQCP GPKEGLQWGV GIPKGREEAG SGWGLAASPT
RSEAPCPPPG PNETAPFKPE GELHELGAKL LLHYSPQACK NNICLDLSPG HGLDGRLTGH
RVETWDVKDV VNCVGGMGAL LPLLERVAAQ PQEAEAGPAE THDLVGPELT SGHNVQGLLL
PLGKSSEKRM EKNAVAAFLL MLRNFLQGHP VNQESLVHCQ GPAIIGALLR KVPSWAMDMN
VLMSAQLLME QVAAEGSGPL LYLLYQHLLF NFHLWTLSDF AVRLGHIQYV SSIVREHRQK
LRKKYGVQFI LDALRVHYSP QRERPLAADD LRTVQTSLLG LAREFLVRSS TADDLQVVLN
FLAASGDDGQ VVGALDLLLA LLQGSPAQES LAVFLLEPGN LEVLLALLVR PRPMPLLPDR
VCKILRRLQQ NERLPERSRQ RLRLRECGLQ GLVACLPEGA VSPQLCQGLY KLFLGADCLN
LSDLLAVVQL SLQADLSVRL DICRQLFHLI YGQPDIVRLL ARQAGWQDVL TRLFVLEAVT
AGSPLPFTPE PPTSPEPASH KPPTESPEPS DVFLPPEAPD PDAFYHALSP FATPFELGLE
RASVSSGNTA GGGSSSGTVT PASQPGTPSP LDGPRPFPMA QGRHSSSLSN VLEDGSLPEP
TISGDDTSNT SNPQQTCEEE LCNLLTNVLF SVTWRGVDGS DEAAWRERGQ VFSVLTQLGA
SATLVRPPDC IKRSLLEMML ESALTDIKEA PTGVLASLTQ QALWLLRLLQ DFLCAEGHGN
QELWSEKLFE GVCSLLDRLG AWPHLANGTA DLREMAQIGL RLVLGYILLE DPQLHAQAYV
KLHALLQTAV PMRREEACYV LSKLEAALAR ALNNSPSETP TENGEPPAAA AVALVRTLLD
RAYGPLGLQW GLPSLPPTNG SPTFFEDFQA FCATPEWRHF IDKQVQPTMS QFEMDTYAKS
HDLMSGFWNA CYDMLMSSGQ RRQRERAHSR RAFQELVLDP VQRRARSGEC LRRSLGGRQR
GLQTSASYWG HICRDPPTPH WKLSSAETYS RMRLKLVPNH HFNPHLEASA LRDNLGEAPL
TPTEEASLPL AVTKEAKVSS LPEELQEDQL GEDELAALET PLEAADLDEQ HENLVLSAEC
QLVTVVAVVP GLLEVTTQHV YFYDGSAERV ETEEGIGHDF RRPLAQLREV HLRRFNLRRS
ALELFFIDQA NYFLNFPCKT GGAAASSPSQ APRPQPSLIP PHTQVRNQVY SWLLRLRPPT
QGYLSSRSPP EMLRASGLTQ KWVQREISNF EYLMQLNTIA GRTYNDLSQY PVFPWVLQDY
VSPTLDLSNP AVFRDLSKPI GVVNPKHAQL VKEKYESFED PAGTIDKFHY GTHYSNAAGV
MHYLIRVEPF TSLHVQLQSG RFDCSDRQFH SVAAAWQARL ESPADVKELI PEFFYFPDFL
ENQNGFDLGC LQLTNEKVGD VVLPPWASSP EDFIQQHRRA LESEYVSAHL HEWIDLIFGY
KQRGPAAEEA LNVFYYCTYE GAVDLDQVAD ERERRALEGI ISNFGQTPCQ LLKEPHPARL
SVEEAAQRLA RLDTNSPSIF QHLGQLKAFF AEVISDGVPL VLALVPHRQP HSFITQGSAD
LLVTVSANGL LGTHSWLPYD RNISNYFSFS KDPTMGNPKM QRLLSGPWAP GGGVSGQALA
VAPDGKLLFS GGHWDGSLRV TALPRGRLLS QLRCHLDIVT CLALDTCGIY LISGSRDTTC
MVWRLMQQSG LSMGLASKPV QVLYGHEAAV SCVAISTELD MAVSGSEDGT VIIHTVRRGQ
FVATLSPPGS TLPGPVSHLV LGSEGQIVVQ SSARERLGAQ VTYSLHLYSV NGRLRASLPL
VEQPTALAVT EDFVLLGTAQ CALHILHLNK LLPAAPPLPM KVPIRSVAVT KERSHVLVGL
EDGKLIVVGA GQPSEVRSSQ FARKLWRSSS RRISQVSSGE TEYNPGEAR
//
