ID W5P7J8_SHEEP Unreviewed; 3841 AA.
AC W5P7J8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Dystonin {ECO:0008006|Google:ProtNLM};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000006402.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000006402.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000006402.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000006402.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; AMGL01057965; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01057966; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01057967; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01057968; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01057969; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01057970; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01057971; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01057972; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01057973; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01057974; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR SMR; W5P7J8; -.
DR STRING; 9940.ENSOARP00000006402; -.
DR PaxDb; 9940-ENSOARP00000006402; -.
DR Ensembl; ENSOART00000006499.1; ENSOARP00000006402.1; ENSOARG00000005969.1.
DR eggNOG; KOG0516; Eukaryota.
DR eggNOG; KOG0517; Eukaryota.
DR HOGENOM; CLU_000015_3_0_1; -.
DR Proteomes; UP000002356; Chromosome 20.
DR Bgee; ENSOARG00000005969; Expressed in skeletal muscle tissue of biceps brachii and 49 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR CDD; cd21236; CH_DYST_rpt1; 1.
DR CDD; cd21239; CH_DYST_rpt2; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.1060; -; 1.
DR Gene3D; 1.20.58.60; -; 7.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 3.90.1290.10; Plakin repeat; 3.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR041615; Desmoplakin_SH3.
DR InterPro; IPR041573; Desmoplakin_Spectrin-like.
DR InterPro; IPR049538; PCN-like_spectrin-like_rpt.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR035915; Plakin_repeat_sf.
DR InterPro; IPR001101; Plectin_repeat.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR PANTHER; PTHR23169:SF21; EPIPLAKIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00681; Plectin; 2.
DR Pfam; PF17902; SH3_10; 1.
DR Pfam; PF00435; Spectrin; 1.
DR Pfam; PF18373; Spectrin_2; 1.
DR Pfam; PF21019; Spectrin_3; 1.
DR Pfam; PF21020; Spectrin_4; 1.
DR Pfam; PF21097; SR_plectin_7; 1.
DR SMART; SM00033; CH; 2.
DR SMART; SM00250; PLEC; 9.
DR SMART; SM00150; SPEC; 6.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF75399; Plakin repeat; 2.
DR SUPFAM; SSF46966; Spectrin repeat; 5.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 35..138
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 151..255
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 887..944
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 521..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2053..2090
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2140..2169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2236..2265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2309..2399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2507..2546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2560..2607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2838..2859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2974..3015
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3133..3158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3239..3259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 12..39
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 670..697
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 734..768
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1208..1242
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1418..1448
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3669..3696
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 2070..2086
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2146..2169
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2247..2263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2309..2345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2513..2527
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2528..2546
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2570..2594
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3133..3155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3841 AA; 430595 MW; 5CD93F6BD20255E7 CRC64;
MAGYLSPAAY LCVDEQEYLQ AYEDVLERYK DERDKVQKKT FTKWINQHLM KVRKHVNDLY
EDLRDGHNLI SLLEVLSGDT LPREKGRMRF HRLQNVQIAL DYLKRRQVKL VNIRNDDITD
GNPKLTLGLI WTIILHFQIS DIHVTGESED MSAKERLLLW TQQATEGYAG IRCENFTTCW
RDGKLFNAII HKYRPDLIDM NTVAVQSNLA NLEHAFYVAE KIGVIRLLDP EDVDVSSPDE
KSVITYVSSL YDAFPKVPEG GEGIGANDVE VKWIEYQNMV NYLVQWIRHH VATMSERTFP
NNPVELKALY NQYLQFKETE IPPKETEKSK IKRLYKLLEI WIEFGRIKLL QGYHPNDIEK
EWGKLIIAML EREKALRPEV ERLEMLQQIA NRVQRGSVIC EDKLLLARNA LQSDSKRLES
GLQFQNEAEI AGYILECENL LRQHVIDVQI LIDGKYYQAD QLVQRVAKLR DDIMALRNEC
SSVYSKGRVL TTEQTKLMIS GISQSLNSGF AQTLHPSMNS GLTQGLTPSL TPSSVTSGLS
SGLTSRLTPS ATPAYTPGFP SGLVPNFGSG GETSSLQTLK LMQIRKPLLK SSLLDQNLTE
EEINMKFVQD LLNWVDEMQV QLDRTEWGSD LPSVESHLEN HKNVHRAIEE FESSLKEAKI
SEIQMTAPLK LTYAEKLHRL ENQYAKLLNT SRNQERHLDT LHNFVTRATN ELIWLNEKEE
EEVAYDWSER NTNIARKRDY HAELMRELDQ KEETIKSVQE IAEQLLLENH PARLTIEAYR
AAMQTQWSWI LQLCQCVEQH VKENGAYFEF FNDAKEATDY LRNLKDAIQR KYSCDRSSSI
HKLEDLVQES MEEKEELLQY KSTVASLMGR AKTIVQLKPR NPDYPLKTSL PIKAICDYRQ
IEITIFKDDE CVLANNSHRA KWKVISPTGN EAMVPSVCFT VPPPNKEAVD FANRIEQQYQ
NVLTLWHESH INMKSVVSWH YLINEIDRIR ASNVASIKTM LPGEHQQVLS NLQSRFEDFL
EDSQESQIFS GSDITQLEKE VNVCKQYYQE LLKSAEREEQ EESAYNLYIS EVRNLRLRLE
SCEDRLIRQI RTPLERDDLH ESVFRISEQE KLKKELERLK DDLATITSKC EDFFSQAPAS
ASTPALRSEL SVVVQSMNHV YSMSSTYIEK LKTVNLVLKN TQAAEALVKL YETKLCEEEA
VIADKNNIEN LISTLKQWRS EVDEKREVFH ELEDELQRAK TISDEMFKTY KERDLDFDWH
KEKADQLVER WQNVHVQIDN RLRDLEGIGK SLKYYRDTYH LLDDWIQQVE TTQRKIQENQ
PENSKTLATQ LNQQKMLVSE IEMKQSKMDE CQKYAEQYST AVKDYELQTM TYRAMVDSQQ
KSPVKRRRMQ SSADLVIQEF MDLRTRYTAL VTLMTQYIKF AGDSLKRLEE EEKSLEEEKK
EHVEKAKELQ KWVSNISKTL RDGEKAGKSS FSKQKISSEE ISVKKEQLSE ALQGMQLFLA
KHGDKMTDEE RNELEKQVKT LQESYNLFFS ESLKQLQQSQ TLGDIKVEEK LDKVIAGTVD
QSTGEVLSVF QSVLRGLLDY DTGIRLLETQ LMISGLISPE LRTCFNLKDA QSHGLIDEQV
LSQLQELDEM KEIISAVSST RVPVLDALAE GVISESMAIR VLEILLSTGS LVIPATGEQL
TLQKAFQQHL VSSALFSKIL ERQSLCKDLI DPSTSEKVSL IDIMQRSVLQ EDSGMRLLPV
RPQEGGRITL KCGRNVSILR AAHEGLIDRE TMFRLLGAQL LSGGLINSKS GRRLTVEEAV
AEGVMDRDTA NSILTYQVET GGIIHCNPAK RLTVDEAVQC NLIPSSSALL VLEAQRGYVG
LIWPHSGEIF PASSSLQQEL ITNELASKIL EGRQKIAALY IPETCQVIDL EVATQLGIID
NHTASILKSI TLPDKMPNLG DLEACKNARR WLSFCKFQPS MIHDYRLDED AFDGEEPMAT
QSSEQTKKLF LSYLMINSYM DANTGQRLLL YDGDLNEAVG MLLEGCGAEI DTDTPIEECF
DVLRLPGVSL NNTAGRGMGE SPASPSSFDK CHQREPEHKE TPENSTDEEF QELETQVIRS
EFWLSENLAD VIATDLKVKK SPSVYVPSSR SHFTQLGLAD VSLPRQDSEN RLENGENQSQ
LETEEHADEC NHSKNLQKFA SDLITNPMIK SKASRAYDLN ETENEDNISR DSTLFDYSPR
LSALLSHDKL RTEQGSFHDV HGTDSNGKKC ETSTLPFSDQ TESSGQRIRE KFQDQFLGIA
AINISLKGEQ AEEKSFNVGC SNPQVECQSD GFSSDTCGED GNALATSQQE PEDEQSESTV
EGSSGAPTAR AGGHCVGLAP THTPSLEGTV GASAGDYETS LLDDRDGDTD TDSDADFYDT
PLFEDDDHDS LLLEGDDCDC LQPEDYDSLP EEDDWAAPPG EVFYDVSKED EHAVGTQAGL
AGSLGVRGEA QSLQDFLVGA EKAEFSSGEE IQLNSLGSYE VSGPLMESVS EKDSTDDLED
DESDSLTDYE TEGGKENFRT GVESEDAGCW EGREKDCVTG QGFESAPDRL DSVQSKDSYE
DSVPGHKEQD DDGGADAGDC AGGEGAEHVG HGAAAAVVVP GCVAAAPEME NSRASQRNNK
TILPTQKHHH NSSQKQQCVN VLWPESSSKS SLGPEINRFL EDTDEVVGKS IGDLLNHEMV
LQDELLPIMK DTESENTFSR VGALPNTSAS SASELEGHLK NTGLELIQPG SADSVKGGNP
YCENVTLRGD SSSDEIICSE PSLTGKPAEE SHLSFTMSVA DNDPPGSGRD LIKRRADKSN
IQIEDEATVP ELCAVPQTTH REERSQEGSP KNTTVALKDE PQNLPTAVSR SPVQFENLEE
IFDSSVSQVI SDGTTSDRTL SEGFARIETD PLTDGPGDEL DTSLKHCAKD VKAKGVLKPG
EDTPSCIPVA SPHRKEHLQL GVSSADEHAA LAQEDAPAKE MGQQKDLAAE ESRSGIPKFT
PAGDESMPSG FPLGNAEGLG KHMDFVQSDL CADGRRNNSS KGLSTDCSSL EINSEKEVIE
QQKGQEPAPS PGAQGSEVQV AELSQVLVED FTDTLKGNLK EGRVTPQELG KPSACADANT
LIQTLMKRVS SSQLVNETPG VPSDSNTSGC GISRTKNSPE LKAENREDLL CTANLKSELL
LDILKQNQYS QKVIGAFELM KELTQMQCDL EEKGGTSELL PLQLEDVFCR LLPDGYSEKG
GQRRDLNQKS PTAPEVPGEE PHILEEFNSK GGNPCSLNLQ SVKESGPENS PVCAPALSRD
GRLKELCAAS PGRLECISES EDLASGDSSA ERFSKELQQC LQHRSKMCEY LALLQDMKPP
FGSQDSRDGS LETLRDQLKR LETFELGLAP IGVILRKDMT LAEEFVKSVP GDFPRGPLED
LSVSLQSLQT ALSSLQAASS ERMNHITLAI DSEVSKLAVS HEEFLQKLQS FSRWILETSK
SVKDVEITTV RDAELIKQSL EFLKNVLKDL GHTKTQLESA AFDVQFFISE HAQDLSPTQS
RQLLRLLNTT QKGFLDMQDS VTAQVEHLEA QLQLEQDLDL QKLVAERQQE YKEKLQGICD
LLTQTENRLI GHQEAFVIGD GTAELKKYQS KQEELQKDMQ GSAQALAEIV KNTENFLKES
GEKLSREDKA VIEQKLNEAK MKCEQLTVKA EQSKKELDKV VTTAIREETE KVVAAKQLEE
SKTKIENLLD WLANVDRDSG RAAMEPKQII EQNGTHFQEG DSKSMMGEED EFNGNLLDTD
VDGHVGTTEE NLNQQYQKMK VRCFKHDIVR VSFGVYKARK NLAQELSLQS SGTLESKVLF
F
//
