ID W5P8L8_SHEEP Unreviewed; 511 AA.
AC W5P8L8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Beta-1,4 N-acetylgalactosaminyltransferase {ECO:0000256|PIRNR:PIRNR000474};
GN Name=B4GALNT2 {ECO:0000313|Ensembl:ENSOARP00000006773.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000006773.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000006773.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000006773.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000006773.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004323}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family.
CC {ECO:0000256|ARBA:ARBA00006739, ECO:0000256|PIRNR:PIRNR000474}.
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DR EMBL; AMGL01018441; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01018442; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5P8L8; -.
DR STRING; 9940.ENSOARP00000006773; -.
DR PaxDb; 9940-ENSOARP00000006773; -.
DR Ensembl; ENSOART00000006877.1; ENSOARP00000006773.1; ENSOARG00000006320.1.
DR eggNOG; ENOG502QTK7; Eukaryota.
DR OMA; GDCIHRR; -.
DR Proteomes; UP000002356; Chromosome 11.
DR Bgee; ENSOARG00000006320; Expressed in abomasum and 21 other cell types or tissues.
DR ExpressionAtlas; W5P8L8; baseline.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016758; F:hexosyltransferase activity; IEA:InterPro.
DR GO; GO:0034641; P:cellular nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0030259; P:lipid glycosylation; IEA:UniProtKB-UniRule.
DR CDD; cd00761; Glyco_tranf_GTA_type; 1.
DR InterPro; IPR001173; Glyco_trans_2-like.
DR InterPro; IPR011143; GM2_synthase.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR15046:SF2; BETA-1,4 N-ACETYLGALACTOSAMINYLTRANSFERASE 2; 1.
DR PANTHER; PTHR15046; GLYCO_TRANS_2-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00535; Glycos_transf_2; 1.
DR PIRSF; PIRSF000474; GM2_GD2_synthase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|PIRNR:PIRNR000474};
KW Golgi apparatus {ECO:0000256|PIRNR:PIRNR000474};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR000474};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transferase {ECO:0000256|PIRNR:PIRNR000474};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 269..378
FT /note="Glycosyltransferase 2-like"
FT /evidence="ECO:0000259|Pfam:PF00535"
SQ SEQUENCE 511 AA; 57938 MW; 61827D82CF973BFA CRC64;
TAFALLCPNS SRYLWILKMS VLFLALGIVL FMFRSVSLYS EFSIYKAPLL QPSVAAGMLK
LLPEKHIKSL FTHDGIWLFP KNQCKCEAWK LQQSYYFENA YGQTELPAVK MRRQAEFEHF
QRREGLPRPP PLLAQANLPF GYPIHGVEVM PLHTIPIPGL QFEGPDAPIY KVTLKASLGT
LNTLADTPDT VVQGRGQKEL TILTSSRTVL NFILQHVTYT STEYQHPRVD VVSLESNSSV
AKFPVTIRFP VMPKLYDPGP ERKLRNLVSI ATKTFLRPHK LKTMLQSIRV YYPDLTVIVA
DDSKEPLEIN DSYVEYYTMP YGKGWFAGRN LAISQVTTKY VLWVDDDFLF NDKTKIEVLV
DVLEKTELDV VGGSVLGNVF QFKLFLEHSK NGDCLHRRTG SFGPLDGFPN CVVTSGVVNF
FLAHTERLQR VGFDPRLHRV AHSEFFIDGL GSLLVGSCSD VIIGHQPHSS VADPELAALE
KTYRRYRANT NDKVQFKLAL HYFKNHLQCT T
//
