ID W5P941_SHEEP Unreviewed; 623 AA.
AC W5P941;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Baculoviral IAP repeat-containing protein 2 {ECO:0008006|Google:ProtNLM};
GN Name=BIRC2 {ECO:0000313|Ensembl:ENSOARP00000006949.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000006949.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000006949.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000006949.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000006949.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the IAP family. {ECO:0000256|ARBA:ARBA00006672}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMGL01030406; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004016023.1; XM_004015974.3.
DR AlphaFoldDB; W5P941; -.
DR SMR; W5P941; -.
DR STRING; 9940.ENSOARP00000006949; -.
DR MEROPS; I32.007; -.
DR PaxDb; 9940-ENSOARP00000006949; -.
DR Ensembl; ENSOART00000007056.1; ENSOARP00000006949.1; ENSOARG00000006491.1.
DR GeneID; 101119930; -.
DR KEGG; oas:101119930; -.
DR CTD; 329; -.
DR eggNOG; KOG1101; Eukaryota.
DR HOGENOM; CLU_016347_1_1_1; -.
DR OMA; LRDCDPV; -.
DR OrthoDB; 383715at2759; -.
DR Proteomes; UP000002356; Chromosome 15.
DR Bgee; ENSOARG00000006491; Expressed in renal medulla and 54 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0031398; P:positive regulation of protein ubiquitination; IEA:UniProt.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd00022; BIR; 3.
DR CDD; cd08329; CARD_BIRC2_BIRC3; 1.
DR CDD; cd16713; RING-HC_BIRC2_3_7; 1.
DR CDD; cd14394; UBA_BIRC2_3; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR InterPro; IPR001370; BIR_rpt.
DR InterPro; IPR048875; BIRC2-3-like_UBA.
DR InterPro; IPR041933; BIRC2/BIRC3_UBA.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001841; Znf_RING.
DR PANTHER; PTHR10044:SF79; BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR10044; INHIBITOR OF APOPTOSIS; 1.
DR Pfam; PF00653; BIR; 3.
DR Pfam; PF21290; BIRC2-3-like_UBA; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00238; BIR; 3.
DR SMART; SM00114; CARD; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF57924; Inhibitor of apoptosis (IAP) repeat; 3.
DR PROSITE; PS01282; BIR_REPEAT_1; 3.
DR PROSITE; PS50143; BIR_REPEAT_2; 3.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 459..549
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 576..611
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 438..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..456
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 623 AA; 70600 MW; 15A84ED0F7932C2D CRC64;
MHKTTSQRLV LDPSYRKIKS VMEDSTVLSN WTSGNKQKMT YDFSCELYRM STYSTFPTGV
PVSERSLARA GFYYTGVNDK VKCFCCGLML DNWKQGDNPI EKHKQLYPSC SFIQNLVSVT
SLESTSKNAS SPMRNSFTHS LSPTLEHGRS FSGSYSNLSP NPINSRAVED FSPLRTNPYS
YAMSTEEARF LTYQMWPLTF LSPSELARAG FYYIGPGDRV ACFACGGTLN NWEPKDDAML
EHQRNFPNCP FLENSLGTLR FSISNLSMQT HAARLRTFMY WPSTVPVQPE QLASAGFYYV
GRNDDVKCFC CDGGLRCWES GDDPWVEHAK WFPRCEFLIR MKGQEFVSEI QARYPHLLEQ
LLSTANTPGD ENADPPIVQF GPGESSSDDA VMMNTPVVKA ALEMGFSRSL VKRTVQSKIL
TTGENYKTVN DIVSALLNAE DEKREEEEEE EKERQTEETA SDDLSLLRRN RMALFQQLTC
VLPILDNLLK ANVINKQEHD IIKQKTQIPL QARELIDTVL VKGNSAANIF KNCLKEIDPT
LYKNLFVEKN MKYIPTDVSG LSLEEQLRRL QEERTCKVCM DKEVSIVFIP CGHLVVCQEC
APSLRKCPIC RGIIKGTVRT FLS
//
