ID W5P9D7_SHEEP Unreviewed; 421 AA.
AC W5P9D7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Zinc transporter ZIP13 {ECO:0000256|ARBA:ARBA00040592};
DE AltName: Full=Solute carrier family 39 member 13 {ECO:0000256|ARBA:ARBA00042542};
DE AltName: Full=Zrt- and Irt-like protein 13 {ECO:0000256|ARBA:ARBA00042972};
GN Name=SLC39A13 {ECO:0000313|Ensembl:ENSOARP00000007045.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000007045.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000007045.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000007045.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000007045.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351,
CC ChEBI:CHEBI:29105; Evidence={ECO:0000256|ARBA:ARBA00034634};
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004156}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000256|ARBA:ARBA00006939}.
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DR EMBL; AMGL01033392; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01033393; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01033394; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01033395; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5P9D7; -.
DR STRING; 9940.ENSOARP00000007045; -.
DR PaxDb; 9940-ENSOARP00000007045; -.
DR Ensembl; ENSOART00000007152.1; ENSOARP00000007045.1; ENSOARG00000006581.1.
DR eggNOG; KOG2694; Eukaryota.
DR HOGENOM; CLU_015114_0_2_1; -.
DR OMA; TGDSVHC; -.
DR Proteomes; UP000002356; Chromosome 15.
DR Bgee; ENSOARG00000006581; Expressed in thyroid gland and 51 other cell types or tissues.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR003689; ZIP.
DR PANTHER; PTHR16950; ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4; 1.
DR PANTHER; PTHR16950:SF16; ZINC TRANSPORTER ZIP13; 1.
DR Pfam; PF02535; Zip; 3.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..421
FT /note="Zinc transporter ZIP13"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004868645"
FT TRANSMEM 69..90
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 110..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 152..171
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 399..420
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 340..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 421 AA; 43435 MW; 4D695BD40AB32F6B CRC64;
MPGCPCPGIG MAGQRLLFLV ALALELLGGA GGSQQALRSR GVAAACRLED NKESESWGAL
LSGERLETWI CSLLGSLMVG LSGVFPLLVI PLEMGTTLRS EAGARRLKQL LSFALGGLLG
NVFLHLLPEA WAYTNSASSG GEGRSLQQQQ QLGLWVIAGF LTFLVLEKLF LDSKGKEENS
QAPSKDPAAA AALNGGHYLA QPAAEPGLSA VVRNIKVSGP LGAPLPTAAP PRVAGPAPAP
LPPSLLQTLL VGTTGLSQHE IPHEVGDFAI LLRAGFDRWS AAKLQLSTAL GGLLGACFAI
CAQSPKGVGT GVGVVAVCRG ALAEGHGCPD PGIQARLCPG PPHGRGGGRG TGPQPVRAPP
PAAEETVAWI LPFTSGGFLY IALVNVLPDL LEEDDPWHSL QQVLLLCAGI VVMVLFSVFV
E
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