ID W5P9P0_SHEEP Unreviewed; 1285 AA.
AC W5P9P0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Unconventional myosin-VI {ECO:0000256|ARBA:ARBA00015382};
DE AltName: Full=Unconventional myosin-6 {ECO:0000256|ARBA:ARBA00030027};
GN Name=MYO6 {ECO:0000313|Ensembl:ENSOARP00000007149.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000007149.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000007149.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000007149.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000007149.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, filopodium
CC {ECO:0000256|ARBA:ARBA00004486}. Cell projection, microvillus
CC {ECO:0000256|ARBA:ARBA00004105}. Cell projection, ruffle membrane
CC {ECO:0000256|ARBA:ARBA00004632}. Cytoplasmic vesicle, clathrin-coated
CC vesicle {ECO:0000256|ARBA:ARBA00004132}. Golgi apparatus, trans-Golgi
CC network membrane {ECO:0000256|ARBA:ARBA00004150}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004150}. Membrane, clathrin-coated pit
CC {ECO:0000256|ARBA:ARBA00004600}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; AMGL01105438; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01105439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01105440; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012037802.1; XM_012182412.2.
DR SMR; W5P9P0; -.
DR STRING; 9940.ENSOARP00000007149; -.
DR PaxDb; 9940-ENSOARP00000007149; -.
DR Ensembl; ENSOART00000007256.1; ENSOARP00000007149.1; ENSOARG00000006673.1.
DR eggNOG; KOG0163; Eukaryota.
DR OMA; MIDHEFE; -.
DR Proteomes; UP000002356; Chromosome 8.
DR Bgee; ENSOARG00000006673; Expressed in adult mammalian kidney and 54 other cell types or tissues.
DR ExpressionAtlas; W5P9P0; baseline.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0005902; C:microvillus; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0007605; P:sensory perception of sound; IEA:UniProtKB-KW.
DR CDD; cd21759; CBD_MYO6-like; 1.
DR CDD; cd22294; MYO6_MIU_linker; 1.
DR CDD; cd01382; MYSc_Myo6; 1.
DR CDD; cd21958; MyUb_Myo6; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.30.70.1590; -; 1.
DR Gene3D; 6.10.220.10; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 2.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR049016; MYO6_lever.
DR InterPro; IPR032412; Myosin-VI_CBD.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR036114; MYSc_Myo6.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF745; UNCONVENTIONAL MYOSIN-VI; 1.
DR Pfam; PF21521; MYO6_lever; 1.
DR Pfam; PF16521; Myosin-VI_CBD; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coated pit {ECO:0000256|ARBA:ARBA00023176};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hearing {ECO:0000256|ARBA:ARBA00022740};
KW Membrane {ECO:0000256|ARBA:ARBA00023176};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 2..53
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 57..771
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 651..673
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 934..955
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1127..1155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1139..1155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 151..158
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1285 AA; 148637 MW; 1B8CAD2D1C3FE0C2 CRC64;
MEDGRPVWAP HPAEGFQMGN IVDIGADSLT IEPLGQKGKT FLALINQVFP AEEDSKKDVE
DNCSLMYLNE ATLLHNIKVR YSKDRIYTYV ANILIAVNPY FDIPKIYSSD TIKLYQGKSL
GTMPPHVFAI ADKAFRDMKV LKMSQSIIVS GESGAGKTEN TKFVLRYLTE SYGTGQDIDD
RIVEANPLLE AFGNAKTVRN NNSSRFGKFV EIHFNEKSSV VGGFVSHYLL EKSRICVQGK
EERNYHIFYR LCAGASEDIR ERLHLSSPDN FRYLNRGCTR YFANKETDKQ ILQNRKTPEH
LKAGSLKDPL LDDHGDFIRM CTAMKKIGLD DEEKLDLFRV VAGVLHLGNI DFEEAGSTSG
GCNLKNKSAQ SLEYCAELLG LDQDDLRVSL TTRVMLTTAG GTKGTVIKVP LKVEQANNAR
DALAKTVYSH LFDHVVNRVN QCFPFETSSY FIGVLDIAGF EYFEHNSFEQ FCINYCNEKL
QQFFNERILK EEQELYQKEG LGVNEVHYVD NQDCIDLIEA KLVGILDILD EENRLPQPSD
QHFTSAVHRK HKDHFRLSIP RKSKLAVHRN IRDDEGFIIR HFAGAVCYET TQFVEKNNDA
LHMSLESLIC ESRDKFVREL FESSTNNNKD TKQKAGKLSF ISVGNKFKTQ LNLLLDKLRS
TGASFIRCIK PNLKMTSHDF EGAQILSQLQ CSGMVSVLDL MQGGFPSRAS FHELYNMYKK
YMPDKLARLD PRLFCKALFK ALGLNEVDYK FGLTKVFFRP GKFAEFDQIM KSDPYHLAEL
VKRVNHWLIC SRWKKVQWCS LSVIKLKNKI KYRAEACIKM QKTIRMWLCK RRHKPRIDGL
VKVGTLKKRL HKFNEVVNAL KDGKPEMNKQ VKDLEISIDA LMAKIKSTMM TREQIQKEYD
ALVQSSEVLL SALQKKKQQE EEAERLRRIQ EEMEKERKRR EEDEQRRRKE EEERRMKLEM
EAKRKQEEEE RKKREDDEKR IQAEVEAQLA RQREEETQQQ AVLEQERRDR ELALRIARSE
AELISDEAQA DLAALRSLDF HPVTKINGTR RTMTPEQMAK EMSEILSRGP AVQATKAAAG
TKKHDLSKWK YAELRDTINT SCDIELLAAC REEFHRRLKV YHAWKSKNKK RNTETEQRAP
KSVTDYAQQN PAAQLPARQQ EIEMNRQQRF FRIPFIRPAD QYKDPQNKKK GWWYAHFDGP
WIARQMELHP DKPPILLVAG KDDMEMCELN LEETGLTRKR GAEILPRQFE EIWERCGGIQ
YLQSAIESRQ ARPTYATAML QNLFK
//
