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Database: UniProt
Entry: W5PBA2_SHEEP
LinkDB: W5PBA2_SHEEP
Original site: W5PBA2_SHEEP 
ID   W5PBA2_SHEEP            Unreviewed;      1152 AA.
AC   W5PBA2;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   24-JAN-2024, entry version 51.
DE   RecName: Full=Large proline-rich protein BAG6 {ECO:0000256|ARBA:ARBA00021614};
DE   AltName: Full=BCL2-associated athanogene 6 {ECO:0000256|ARBA:ARBA00030033};
DE   AltName: Full=HLA-B-associated transcript 3 {ECO:0000256|ARBA:ARBA00029739};
GN   Name=BAG6 {ECO:0000313|Ensembl:ENSOARP00000007713.1};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000007713.1, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000007713.1, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000007713.1,
RC   ECO:0000313|Proteomes:UP000002356};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA   Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000007713.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Released extracellularly via exosomes, it is a ligand of the
CC       natural killer/NK cells receptor NCR3 and stimulates NK cells
CC       cytotoxicity. It may thereby trigger NK cells cytotoxicity against
CC       neighboring tumor cells and immature myeloid dendritic cells (DC).
CC       {ECO:0000256|ARBA:ARBA00002067}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC       Secreted, extracellular exosome {ECO:0000256|ARBA:ARBA00004550}.
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DR   EMBL; AMGL01059048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; W5PBA2; -.
DR   SMR; W5PBA2; -.
DR   STRING; 9940.ENSOARP00000007713; -.
DR   PaxDb; 9940-ENSOARP00000007713; -.
DR   Ensembl; ENSOART00000007828.1; ENSOARP00000007713.1; ENSOARG00000007183.1.
DR   eggNOG; KOG4248; Eukaryota.
DR   HOGENOM; CLU_012159_0_0_1; -.
DR   OMA; NRITVAM; -.
DR   Proteomes; UP000002356; Chromosome 20.
DR   Bgee; ENSOARG00000007183; Expressed in major salivary gland and 52 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0002376; P:immune system process; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   CDD; cd01809; Ubl_BAG6; 1.
DR   InterPro; IPR021925; BAG6.
DR   InterPro; IPR048926; Bag6_BAGS.
DR   InterPro; IPR000626; Ubiquitin-like_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR019954; Ubiquitin_CS.
DR   PANTHER; PTHR15204; LARGE PROLINE-RICH PROTEIN BAG6; 1.
DR   PANTHER; PTHR15204:SF0; LARGE PROLINE-RICH PROTEIN BAG6; 1.
DR   Pfam; PF12057; BAG6; 1.
DR   Pfam; PF20960; Bag6_BAGS; 1.
DR   Pfam; PF00240; ubiquitin; 1.
DR   SMART; SM00213; UBQ; 1.
DR   SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS00299; UBIQUITIN_1; 1.
DR   PROSITE; PS50053; UBIQUITIN_2; 1.
PE   4: Predicted;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW   Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW   Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Spermatogenesis {ECO:0000256|ARBA:ARBA00022871}.
FT   DOMAIN          17..77
FT                   /note="Ubiquitin-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50053"
FT   REGION          87..126
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          186..267
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          380..430
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          450..479
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          579..621
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          671..713
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          966..1077
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1091..1152
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        92..112
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        205..219
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        222..238
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        414..428
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        587..605
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        673..703
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        981..995
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1152 AA;  121191 MW;  BA4C5A08A8863A8C CRC64;
     MEPSDSTSTT MEDPDSLEVL VKTLDSQTRT FIVGAQMNVK EFKEHIAASV SIPSEKQRLI
     YQGRVLQDDK KLQEYNVGGK VIHLVERAPP QTQLPSGASS GTGSTSATHG GGPTPGTRGP
     GASVHDRNAN SYVMVGTFNL PSDGSAVDVH INMEQAPIQS EPRVRLVMAQ HMIRDIQTLL
     SRMECRGGAQ AQHSQPPPQT PTVAPEPVAL TSQTSEPVES EVPPREPMEA EEVEERAPAQ
     SPELTPSGPA PAGPASAPET NAPNHPSPAE YVEVLQELQR LESRLQPFLQ RYYEVLGAAA
     TTDYNNNQEG REEDQRLINL VGESLRLLGN TFVALSDLRC NLACAPPRHL HVVRPMSHYT
     TPMVLQQAAI PIQINVGTTV TMTGNGTRPP PTPSAEAPPA GAGQASSLAP SSTAGAPPPG
     PAPPPTTSHP RVIRISHQSV EPVVMMHMNI QDSGTQPGGV PSAPTGPLGP PGHGQTLGST
     LIQLPSLPPE FMHAVAHQIT HEAMVAAVAS AATGQQVPGF PTAPTRLVIA RPTPPQARPS
     LAGSLPGAGL GTNASLAQMV SGLVGQLLMQ PVLVAQGTPG MAPSPAPATA SASSGTTNTA
     TTAGPAPGGP AQPQPPQAST SDLQFSQLLG NLLGPAGPGT GGPGVASPTI TVAMPGVPAF
     LQGMTDFLQA TQTAAPPPPP PPPPPPPPAP EQQTAPPPGS PSGGSGSPGS VGPESLPLEF
     FTSVVQGVLS SLLGSLGARA GSSESIAAFI QRLSGSSNIF EPGADGALGF FGALLSLLCQ
     NFSMVDVVML LHGHFQPLQR LQPQLRSFFH QHYLGGQEPT PGNIRTATHA LITGLEEYVR
     ESFSLVQVQP GVDIIRTNLE FLQEQFNSIA AHVMHCTDSG FGARLLELCN QGLFECLALN
     LHCLGGQQME LAAVINGRIR RMSRGVNPSL VSWLTTMMGL RLQVVLEHMP VGPDAILRYV
     RRVGDPPQTL PEEPMEVQGS ERSSPEPQRE NASPAPGTTA EEAMSRGPPP APEGGSRDEQ
     DGASAETEPW AAAVPPEWVP IIQQDIQSQR KVKPQPPLSD AYLSGMPAKR RKTMQGEGPQ
     LLLSEAVSRA AKAAGARPLT SPESLSRDLE APEVQESYRQ QLRADIQKRL QEDPNYSPQR
     FPNAHRAFAD DP
//
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