ID W5PBX7_SHEEP Unreviewed; 1191 AA.
AC W5PBX7; A0A6P7DPE8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Structural maintenance of chromosomes protein {ECO:0000256|PIRNR:PIRNR005719};
GN Name=SMC2 {ECO:0000313|Ensembl:ENSOARP00000007938.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000007938.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000007938.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000007938.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000007938.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR005719}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC2 subfamily.
CC {ECO:0000256|ARBA:ARBA00005231}.
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DR EMBL; AMGL01047448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01047449; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004004087.2; XM_004004038.2.
DR AlphaFoldDB; W5PBX7; -.
DR SMR; W5PBX7; -.
DR STRING; 9940.ENSOARP00000007938; -.
DR PaxDb; 9940-ENSOARP00000007938; -.
DR Ensembl; ENSOART00000008055.1; ENSOARP00000007938.1; ENSOARG00000007399.1.
DR eggNOG; KOG0933; Eukaryota.
DR HOGENOM; CLU_001042_9_0_1; -.
DR OMA; HNKIAME; -.
DR OrthoDB; 231904at2759; -.
DR Proteomes; UP000002356; Chromosome 2.
DR Bgee; ENSOARG00000007399; Expressed in thymus and 55 other cell types or tissues.
DR GO; GO:0000794; C:condensed nuclear chromosome; IEA:Ensembl.
DR GO; GO:0000796; C:condensin complex; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0051383; P:kinetochore organization; IEA:Ensembl.
DR GO; GO:0010032; P:meiotic chromosome condensation; IEA:Ensembl.
DR GO; GO:0045132; P:meiotic chromosome segregation; IEA:Ensembl.
DR GO; GO:0007076; P:mitotic chromosome condensation; IEA:Ensembl.
DR GO; GO:1905821; P:positive regulation of chromosome condensation; IEA:Ensembl.
DR GO; GO:0051984; P:positive regulation of chromosome segregation; IEA:Ensembl.
DR GO; GO:1905820; P:positive regulation of chromosome separation; IEA:Ensembl.
DR CDD; cd03273; ABC_SMC2_euk; 1.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 3.30.70.1620; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR024704; SMC.
DR InterPro; IPR027120; Smc2_ABC.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR PANTHER; PTHR43977:SF2; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN; 1.
DR PANTHER; PTHR43977; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 2.
DR PIRSF; PIRSF005719; SMC; 1.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
DR SUPFAM; SSF57997; Tropomyosin; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW DNA condensation {ECO:0000256|ARBA:ARBA00023067};
KW Nucleus {ECO:0000256|PIRNR:PIRNR005719};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
SQ SEQUENCE 1191 AA; 135586 MW; 6E47460B116ADAFF CRC64;
MHIKSVILEG FKSYAQRTEV NGFDPLFNAI TGLNGSGKSN ILDSICFLLG ISNLSQVRAS
NLQDLVYKNG QAGITKALVS ITFDNSDKKQ SPLGFEVHDE ITVTRQVVIG GRNKYLINGV
NANNTRVYDL FCSVGLNVNN PHFLIMQGRI TKVMNMKPPE ILSMIEEAAG TRMYEYKKQN
AQRTIEKKEA KLREIKTILE EEITPTIQKL KEERSSYLEY QKLLREIEHL SRLYIAYQFL
LAEDTKERSA EALKEMQDKI KKLQEEVSEN DKKIKALSHE IEELENRKDK EVGGILRSLE
DALTEAQRVN TKSQSAFDFK KKNLASEENK RKELEKNMVE DSKTLAAKEK EVKKITDGLS
ALQEASNKDA EALAIAQQHF NAVSAGLSSN EDGAEATLAG QMMACKNDIS KTQTEAKQAQ
MKLKHAQQEL KTKQTEIKKM DSGYRKDQEA LEAVKKLKEK LETEMKRLNY EENKEESLLE
RRRQLSRDIS RLKETEEALL ARFPNLRFAY RDPEKNWNRN CVKGLVASLI SVKDTSATTA
LELVAGDRLY NVVVDTEVTG KKLLEKGELK RRYTIIPLNK ISSRCITPET LRIAQNLVGP
NNVHVALSLV EYKPELQKAM EFVFGMTFVC DNMDNAKKVA FDKRIMTRTV TLGGDVFDPH
GTLSGGARSQ ATSILMKFQE LKDVQDELRT KENELQALEE ELANLKNTAE KYRHLKQQWE
MKAEEVDLLQ TKLQQSSYHK QQEELDTLKK IIEESEETLK NTKEIQKKAE EKYEVLENKM
KNAEAEREKE LKDAQKKLDC ARTKADASSK KMKEKQQEVE AITLELEELK REHASYEQQL
EAVKEAIISY EGQIAVMASE VAKNEELVNK AQEEVTKQKE VITAQDNIIK AKYAEVAKHK
EQNNDSQLKI KELDHNISKH KREAEDAAAK VSKMLKDYDW ITVEKHLFGQ PNSTYDFKAN
NPKEAGERLQ KLQEMKEKLG RNVNMRAMNV LTEAEERYND LMKKKRIVEN DKSKILATIE
DLDQKKNQAI NIAWQKVNKD FGSIFSTLLP GANAMLAPPE GQTVLDGLEF KVALGNTWKE
NLTELSGGQR SLVALSLILS MLLFKPAPIY ILDEVDAALD LSHTQNIGHM LRTHFTHSQF
IVVSLKEGMF NNANVLFKTK FVDGVSTVAR FTQCQNGKVP KENESKSKRP K
//
