ID W5PDT4_SHEEP Unreviewed; 538 AA.
AC W5PDT4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Polypeptide N-acetylgalactosaminyltransferase {ECO:0000256|ARBA:ARBA00012644, ECO:0000256|RuleBase:RU361242};
DE EC=2.4.1.- {ECO:0000256|RuleBase:RU361242};
DE AltName: Full=Protein-UDP acetylgalactosaminyltransferase {ECO:0000256|RuleBase:RU361242};
GN Name=GALNT13 {ECO:0000313|Ensembl:ENSOARP00000008598.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000008598.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000008598.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000008598.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000008598.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936,
CC ECO:0000256|RuleBase:RU361242};
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922, ECO:0000256|RuleBase:RU361242}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|RuleBase:RU361242}; Single-pass type II membrane protein
CC {ECO:0000256|RuleBase:RU361242}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. GalNAc-T
CC subfamily. {ECO:0000256|ARBA:ARBA00005680,
CC ECO:0000256|RuleBase:RU361242}.
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DR EMBL; AMGL01053352; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01053353; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01053354; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01053355; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01053356; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01053357; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01053358; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01053359; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01053360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01053361; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PDT4; -.
DR SMR; W5PDT4; -.
DR STRING; 9940.ENSOARP00000008598; -.
DR PaxDb; 9940-ENSOARP00000008598; -.
DR Ensembl; ENSOART00000008723.1; ENSOARP00000008598.1; ENSOARG00000008011.1.
DR eggNOG; KOG3736; Eukaryota.
DR HOGENOM; CLU_013477_0_1_1; -.
DR OMA; NYTRMEV; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000002356; Chromosome 2.
DR Bgee; ENSOARG00000008011; Expressed in cerebellum and 19 other cell types or tissues.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0004653; F:polypeptide N-acetylgalactosaminyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR CDD; cd02510; pp-GalNAc-T; 1.
DR CDD; cd00161; RICIN; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR InterPro; IPR045885; GalNAc-T.
DR InterPro; IPR001173; Glyco_trans_2-like.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR PANTHER; PTHR11675; N-ACETYLGALACTOSAMINYLTRANSFERASE; 1.
DR PANTHER; PTHR11675:SF47; POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 13; 1.
DR Pfam; PF00535; Glycos_transf_2; 1.
DR Pfam; PF00652; Ricin_B_lectin; 1.
DR SMART; SM00458; RICIN; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF50370; Ricin B-like lectins; 1.
DR PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|RuleBase:RU361242};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000256|RuleBase:RU361242};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW ECO:0000256|RuleBase:RU361242};
KW Lectin {ECO:0000256|ARBA:ARBA00022734, ECO:0000256|RuleBase:RU361242};
KW Manganese {ECO:0000256|ARBA:ARBA00023211, ECO:0000256|RuleBase:RU361242};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Signal {ECO:0000256|SAM:SignalP};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU361242};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..538
FT /note="Polypeptide N-acetylgalactosaminyltransferase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004869201"
FT DOMAIN 393..517
FT /note="Ricin B lectin"
FT /evidence="ECO:0000259|SMART:SM00458"
SQ SEQUENCE 538 AA; 61791 MW; 66FA89D598F1C56E CRC64;
MFVCICVLCV CLTAVISRNQ EGPGEMGKAV LIPKDDQEKM KELFKINQFN LMASDLIALN
RSLPDVRLEG CKTKVYPDEL PNTSVVIVFH NEAWSTLLRT VYSVINRSPH YLLSEVILVD
DASERDFLKL TLENYVKNLE VPVKIIRMEE RSGLIRARLR GAAASKGQVI TFLDAHCECT
LGWLEPLLAR IKEDRKTVVC PIIDVISDDT FEYMAGSDMT YGGFNWKLNF RWYPVPQREM
DRRKGDRTLP VRTPTMAGGL FSIDRNYFEE IGTYDAGMDI WGGENLEMSF RIWQCGGSLE
IVTCSHVGHV FRKATPYTFP GGTGHVINKN NRRLAEVWMD EFKDFFYIIS PGVVKVDYGD
VSVRKTLREN LKCKPFSWYL ENIYPDSQIP RRYYSLGEIR NVETNQCLDN MGRKENEKVG
IFNCHGMGGN QVFSYTADKE IRTDDLCLDV SRLNGPVIML KCHHMRGNQL WEYDAETHTL
LHIITQSCLS VSKVADGSQQ PAVEICNDSP LQKWLLRNYT RMEIFRNIFK NSTDYFLK
//
