ID W5PEJ3_SHEEP Unreviewed; 245 AA.
AC W5PEJ3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Lymphotoxin-beta {ECO:0000256|ARBA:ARBA00017745};
DE AltName: Full=Tumor necrosis factor C {ECO:0000256|ARBA:ARBA00030168};
DE AltName: Full=Tumor necrosis factor ligand superfamily member 3 {ECO:0000256|ARBA:ARBA00033262};
GN Name=LTB {ECO:0000313|Ensembl:ENSOARP00000008857.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000008857.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000008857.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000008857.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000008857.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
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DR EMBL; AMGL01059051; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PEJ3; -.
DR STRING; 9940.ENSOARP00000008857; -.
DR PaxDb; 9940-ENSOARP00000008857; -.
DR Ensembl; ENSOART00000008986.1; ENSOARP00000008857.1; ENSOARG00000008259.1.
DR eggNOG; ENOG502SMSQ; Eukaryota.
DR HOGENOM; CLU_096531_0_0_1; -.
DR OMA; GAWMKGQ; -.
DR Proteomes; UP000002356; Chromosome 20.
DR Bgee; ENSOARG00000008259; Expressed in popliteal lymph node and 49 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR006053; TNF.
DR InterPro; IPR002961; TNF_C.
DR InterPro; IPR021184; TNF_CS.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR11471:SF29; LYMPHOTOXIN-BETA; 1.
DR PANTHER; PTHR11471; TUMOR NECROSIS FACTOR FAMILY MEMBER; 1.
DR Pfam; PF00229; TNF; 1.
DR PRINTS; PR01234; TNECROSISFCT.
DR PRINTS; PR01237; TNFC.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS00251; TNF_1; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 91..244
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
FT REGION 57..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 245 AA; 26170 MW; 9954D959E5571995 CRC64;
MGERGLEGRG RRPQRKGCLL LAVAGVTSLV TLLLAVPITV VAVLALVPQE QGGLVTGTAD
PGAQAPAHQR FESGELPEED SETDLSPRLP AAHLIGAWTT GQGLGWEAKK EEAFLSSGTL
FSGAEGLALP QDGLYYLYCH VGYRGRAPPP AVEPLDRSVT LLSRLYRGGA YGSGTPELLL
EGAETVTPVS DPARRHDYGP LWYTSVGFGG LVQLRRGERV YVNISHPDMV DYRRGKTFFG
AVMVG
//
