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Database: UniProt
Entry: W5PET4_SHEEP
LinkDB: W5PET4_SHEEP
Original site: W5PET4_SHEEP 
ID   W5PET4_SHEEP            Unreviewed;       401 AA.
AC   W5PET4;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   24-JAN-2024, entry version 50.
DE   SubName: Full=Lymphotoxin beta receptor {ECO:0000313|Ensembl:ENSOARP00000008949.1};
GN   Name=LTBR {ECO:0000313|Ensembl:ENSOARP00000008949.1};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000008949.1, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000008949.1, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000008949.1,
RC   ECO:0000313|Proteomes:UP000002356};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA   Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000008949.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR   EMBL; AMGL01083624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; W5PET4; -.
DR   SMR; W5PET4; -.
DR   STRING; 9940.ENSOARP00000008949; -.
DR   PaxDb; 9940-ENSOARP00000008949; -.
DR   Ensembl; ENSOART00000009079.1; ENSOARP00000008949.1; ENSOARG00000008343.1.
DR   eggNOG; ENOG502S4WF; Eukaryota.
DR   HOGENOM; CLU_052594_0_0_1; -.
DR   OMA; NNCVPCK; -.
DR   Proteomes; UP000002356; Chromosome 3.
DR   Bgee; ENSOARG00000008343; Expressed in rectum and 52 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0048534; P:hematopoietic or lymphoid organ development; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:InterPro.
DR   CDD; cd10578; TNFRSF3; 1.
DR   Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 2.
DR   InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR   InterPro; IPR017349; TNFR_3_LTBR.
DR   InterPro; IPR033997; TNFRSF3_N.
DR   PANTHER; PTHR47607; TUMOR NECROSIS FACTOR RECEPTOR SUBFAMILY MEMBER 3; 1.
DR   PANTHER; PTHR47607:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 3; 1.
DR   Pfam; PF00020; TNFR_c6; 3.
DR   PRINTS; PR01920; TNFACTORR3.
DR   SMART; SM00208; TNFR; 4.
DR   SUPFAM; SSF57586; TNF receptor-like; 2.
DR   PROSITE; PS00652; TNFR_NGFR_1; 1.
DR   PROSITE; PS50050; TNFR_NGFR_2; 3.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           28..401
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004870866"
FT   TRANSMEM        230..253
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          49..87
FT                   /note="TNFR-Cys"
FT                   /evidence="ECO:0000259|PROSITE:PS50050"
FT   REPEAT          49..87
FT                   /note="TNFR-Cys"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT   DOMAIN          89..131
FT                   /note="TNFR-Cys"
FT                   /evidence="ECO:0000259|PROSITE:PS50050"
FT   REPEAT          89..131
FT                   /note="TNFR-Cys"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT   REPEAT          176..217
FT                   /note="TNFR-Cys"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT   DOMAIN          176..217
FT                   /note="TNFR-Cys"
FT                   /evidence="ECO:0000259|PROSITE:PS50050"
FT   REGION          204..224
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          318..348
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        208..223
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        50..65
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT   DISULFID        66..79
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT   DISULFID        69..87
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT   DISULFID        90..105
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT   DISULFID        177..192
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ   SEQUENCE   401 AA;  43839 MW;  DC21B559465B85E8 CRC64;
     MRLPWATSHS GLAWGLLILG IWGLLAAAQP QLEREGPMQG LPYHTENQSC GDQEKEYYES
     KLRLCCSRCP PGTHISTKCS RLQNTVCATC PEKSYNEHWN HLSFCQLCRP CDKMLGFVEL
     MPCTSNRKTQ CHCQPGMYCV FWNSECEHCE PLSDCPPGTE AELKDEVTEA NSNCVPCKAG
     HFQNTSSPTA RCQPHTRCED QGLVEEAPGT PQSDTSCRNP QEPSDMPGTM LVLAILLPLV
     SFLLLTTVFI YTWKSHPSLC RKLGSLLKRH PEGEESNPAD GNWEPPRFNT HVPDLVKPLL
     PAPLASAGVP ANPGLEEEVL QQQSPLSQAR DLDAEPPEQG QVAPGTNGIH VTGGSVTVTG
     NIYIYNGPVL GGARGPGPPP YQEDGKAWHL AETETLGCYA L
//
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