ID W5PFD2_SHEEP Unreviewed; 733 AA.
AC W5PFD2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Calponin-homology (CH) domain-containing protein {ECO:0000259|PROSITE:PS50021};
GN Name=HOOK1 {ECO:0000313|Ensembl:ENSOARP00000009147.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000009147.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000009147.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000009147.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000009147.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the hook family.
CC {ECO:0000256|ARBA:ARBA00006946}.
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DR EMBL; AMGL01001826; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01001827; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01001828; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01001829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01001830; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PFD2; -.
DR SMR; W5PFD2; -.
DR STRING; 9940.ENSOARP00000009147; -.
DR PaxDb; 9940-ENSOARP00000009147; -.
DR Ensembl; ENSOART00000009280.1; ENSOARP00000009147.1; ENSOARG00000008518.1.
DR eggNOG; ENOG502QW1T; Eukaryota.
DR HOGENOM; CLU_011214_1_0_1; -.
DR OMA; TYKKQVQ; -.
DR Proteomes; UP000002356; Chromosome 1.
DR Bgee; ENSOARG00000008518; Expressed in omasum and 49 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IEA:InterPro.
DR GO; GO:0030705; P:cytoskeleton-dependent intracellular transport; IEA:InterPro.
DR CDD; cd22225; HkD_Hook1; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR008636; Hook_C.
DR InterPro; IPR043936; HOOK_N.
DR PANTHER; PTHR18947; HOOK PROTEINS; 1.
DR PANTHER; PTHR18947:SF36; PROTEIN HOOK HOMOLOG 1; 1.
DR Pfam; PF05622; HOOK; 1.
DR Pfam; PF19047; HOOK_N; 1.
DR SUPFAM; SSF116907; Hook domain; 1.
DR PROSITE; PS50021; CH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 13..129
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT COILED 173..436
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 482..663
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 733 AA; 85176 MW; 7C997CA0CA615C4D CRC64;
QNKQQPLKKS CLELSDKLVF IHLQTFNTAA PCQDAKQLTS GVAMAQVLHQ IDIAWFDESW
LSRIKEDTGD NWRIKASNLK KVLQGIMSYY NEFLGQQISE ELIPDLNQIT ECSDSVELGR
LLQLILGCAV NCEKKQVIEH IQNIMTLEES VQHVVMTAIQ ELMSKEIVSS PTNDAVGELE
QQLKRALEEL QEALAEKEEL RQRCQELDMQ VTALQDEKNS LVSENEMMNE KLDQLDGSFD
DPNTMVAKKY FHAQLQLEQL QEENFRLEAA KDDYRVHCEE LEKQLIEFQH RNDELTSLAE
ETRALKDEID VLRATSDKAN KLESTVEIYR QKLQDLNDLR KQVKTLQETN MMYMHNTVSL
EEELKKANAA RTQLETYKRQ VQDLHVKLSS ESKRADTLAF EMKRLEEKHE ALLKEKERLI
EQRDTLKETN EELRCSQVQQ DHLNQADASA TKSYENLAAE IMPVEYREVF IRLQHENKML
RLQQEGTENE RIEELQEQLE QKHRKMNELE TEQRLSKERI RELQQQIEDL QKSLQEQGSK
SEGESSSKLK QKLEAHMEKL TEVHEELQKK QELIEDLQPD VNQNAIVQKI NELEAALQKK
DEDMKAMEER YKMYLEKARN VIKTLDPKLN PASAEIMLLR KQLAEKERRI EILESECKVA
KFRDYEEKLI VSAWYNKSLA FQKLGMESRL VSSSGACKDT GACAPARSFL AQQRHITSTR
RSLSVKVPAA TTD
//
