ID W5PG32_SHEEP Unreviewed; 151 AA.
AC W5PG32;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Iron-sulfur cluster assembly 1 homolog, mitochondrial {ECO:0000256|ARBA:ARBA00039743};
DE AltName: Full=HESB-like domain-containing protein 2 {ECO:0000256|ARBA:ARBA00042131};
DE AltName: Full=Iron-sulfur assembly protein IscA {ECO:0000256|ARBA:ARBA00042982};
GN Name=ISCA1 {ECO:0000313|Ensembl:ENSOARP00000009397.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000009397.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000009397.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000009397.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000009397.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in the maturation of mitochondrial 4Fe-4S proteins
CC functioning late in the iron-sulfur cluster assembly pathway. Probably
CC involved in the binding of an intermediate of Fe/S cluster assembly.
CC {ECO:0000256|ARBA:ARBA00037081}.
CC -!- SUBUNIT: Interacts with CRY2, but not with CRY1 (in vitro).
CC {ECO:0000256|ARBA:ARBA00038528}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the HesB/IscA family.
CC {ECO:0000256|ARBA:ARBA00006718}.
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DR EMBL; AMGL01048164; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01048165; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PG32; -.
DR SMR; W5PG32; -.
DR STRING; 9940.ENSOARP00000009397; -.
DR PaxDb; 9940-ENSOARP00000009397; -.
DR Ensembl; ENSOART00000009534.1; ENSOARP00000009397.1; ENSOARG00000008757.1.
DR eggNOG; KOG1120; Eukaryota.
DR HOGENOM; CLU_069054_4_0_1; -.
DR OMA; GCAGQEY; -.
DR Proteomes; UP000002356; Chromosome 2.
DR Bgee; ENSOARG00000008757; Expressed in heart right ventricle and 53 other cell types or tissues.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:InterPro.
DR Gene3D; 2.60.300.12; HesB-like domain; 1.
DR InterPro; IPR000361; FeS_biogenesis.
DR InterPro; IPR016092; FeS_cluster_insertion.
DR InterPro; IPR017870; FeS_cluster_insertion_CS.
DR InterPro; IPR035903; HesB-like_dom_sf.
DR NCBIfam; TIGR00049; iron-sulfur cluster assembly accessory protein; 1.
DR PANTHER; PTHR10072:SF41; IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL; 1.
DR PANTHER; PTHR10072; IRON-SULFUR CLUSTER ASSEMBLY PROTEIN; 1.
DR Pfam; PF01521; Fe-S_biosyn; 1.
DR SUPFAM; SSF89360; HesB-like domain; 1.
DR PROSITE; PS01152; HESB; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 47..146
FT /note="FeS cluster biogenesis"
FT /evidence="ECO:0000259|Pfam:PF01521"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 151 AA; 16687 MW; 5C2947117E0033C5 CRC64;
VHGERLRWPT SSPKHRGGRT ARMSASLVRA TVRAVSKRKL QPTRAALTLT PSAVNKIKQL
LKDKPEHVGV KVGVRTRGCN GLSYTLEYTK TKGDSDEEVI QDGVRVFIEK KAQLTLLGTE
MDFVEDKLSS EFVFNNPNIK GTCGCGESFN I
//
