ID W5PI46_SHEEP Unreviewed; 1197 AA.
AC W5PI46;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Protein kinase C-binding protein 1 {ECO:0008006|Google:ProtNLM};
GN Name=ZMYND8 {ECO:0000313|Ensembl:ENSOARP00000010114.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000010114.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000010114.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000010114.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000010114.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AMGL01026320; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01026321; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01026322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01026323; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01026324; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01026325; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PI46; -.
DR SMR; W5PI46; -.
DR STRING; 9940.ENSOARP00000010114; -.
DR PaxDb; 9940-ENSOARP00000010114; -.
DR Ensembl; ENSOART00000010261.1; ENSOARP00000010114.1; ENSOARG00000009419.1.
DR eggNOG; KOG3612; Eukaryota.
DR HOGENOM; CLU_008433_0_0_1; -.
DR OMA; MPVQRFN; -.
DR Proteomes; UP000002356; Chromosome 13.
DR Bgee; ENSOARG00000009419; Expressed in uterus and 53 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd05508; Bromo_RACK7; 1.
DR CDD; cd15538; PHD_PRKCBP1; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 6.10.140.2220; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR044075; PRKCBP1_PHD.
DR InterPro; IPR000313; PWWP_dom.
DR InterPro; IPR021931; ZMYND8.
DR InterPro; IPR037967; ZMYND8_Bromo_dom.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR002893; Znf_MYND.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46453; PROTEIN KINASE C-BINDING PROTEIN 1; 1.
DR PANTHER; PTHR46453:SF3; PROTEIN KINASE C-BINDING PROTEIN 1; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF12064; DUF3544; 1.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00249; PHD; 1.
DR SMART; SM00293; PWWP; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF144232; HIT/MYND zinc finger-like; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50812; PWWP; 1.
DR PROSITE; PS01360; ZF_MYND_1; 1.
DR PROSITE; PS50865; ZF_MYND_2; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00134}.
FT DOMAIN 88..132
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 164..234
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 276..312
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT DOMAIN 1009..1043
FT /note="MYND-type"
FT /evidence="ECO:0000259|PROSITE:PS50865"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 412..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 582..879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1047..1197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..444
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..514
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..644
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 660..702
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 715..740
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 796..879
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1047..1084
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1095..1167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1197 AA; 132703 MW; 5F22C625A48FEAEB CRC64;
MDISTRSKDP GSTERTAQKR KFPSPPHSSN GHSPQDTSTS PIKKKKKPGL LNNNNKEQSE
LRHGPFYYMK QPLTTDPVDV VPQDGRNDFY CWVCHREGQV LCCELCPGVY HACLRLTSEP
EGDWFCPECE KITVAECIET QSKAMTMLTI EQLSYLLKFA IQKMKQPGTD AFQKPVPLEQ
HPDYAEYIFH PMDLCTLEKN AKKKMYGCTE AFLADAKWIL HNCIIYNGGN HKLTQIAKVV
IKICEHEMNE IEVCPECYLA ACQKRDNWFC EPCSNPHPLV WAKLKGFPFW PAKALRDKDG
QVDARFFGQH DRWELNTGFK CIAPIKFCLS SLAEKKNEFQ RKLSEIPLFI DSFMLNYGVF
NYSPFRTPYT PNSQYQMLLD PSNPGAGAAK MDKQEKVKLS FDMTASPKIL MSKPMLSGGA
GRRISLSDMP RSPMSTNSSV HTGSDVEQDA EKKATSSHFS ASEESMDFLD KSTASPASTK
TGQAGSLSGS PKPFSPQVST PVTTKTDKTP TTGSILNLNL DRSKAEMDLK ELSESVQQQS
TPVPLISPKR QIRSRFQLNL DKTIESCKAQ LGINEISEDV YTAVEHSDSE DSEKSDSSGS
DSISDEEQRS KNEPEDAEDK EGARMDKEPS AVKKKPKLPN PVETKEELKV STSPASEKAD
PSSVKEKTSP QPEKDFSDKA KPSPHPTKDK LKGKDETDSP TVHLGLDSDS ESELVIDLGE
DHSGREGRKN KKEPKEPSPK QEVVGKAPPS TPAGSQSPPE TPVLTRTPAP PPTTTTGSPV
KKQRPLLPKE TAPAVQRVVW NSSSKFQTSS QKWHMQKMQR QQQQQQQQQQ QQQPQSSQGT
RYQTRQAVKA VQQKEITQSP STSTITLVTS TQSSPLVTSS GTTSTLASSV SADLPIATAS
ADVAADIAKY TSKMMDAIKG TMTEIYNDLS KNTTGSTIAE IRRLRIEIEK LQWLHQQELS
EMKHNLDLTF LTTNSSLGQE RDRLIAEVKK QLELEKQQAV DETKKKQWCA NCKKEAIFYC
CWNTSYCDYP CQQAHWPEHM KSCTQSATAP QQEADPEVNT ETLTKSSQGT SSSTQAAPTE
SSASKEKETP AEKSKDGGSN ATVDLSGSRE TPSSILLGSN QGSVSNRCDK QPASAPTSTD
HQPHPNYPAQ KYHSRSSKSS CWSGSEEKRG SARSEHNAGT SSKSLIPKES RLDTFWD
//
