ID W5PI73_SHEEP Unreviewed; 345 AA.
AC W5PI73; A0A6P7EC71;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Sulfotransferase {ECO:0000256|RuleBase:RU361155};
DE EC=2.8.2.- {ECO:0000256|RuleBase:RU361155};
GN Name=HS3ST5 {ECO:0000313|Ensembl:ENSOARP00000010141.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000010141.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000010141.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000010141.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000010141.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sulfotransferase 1 family.
CC {ECO:0000256|RuleBase:RU361155}.
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DR EMBL; AMGL01106314; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01106315; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01106316; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01106317; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01106318; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004011237.1; XM_004011188.3.
DR RefSeq; XP_012037950.1; XM_012182560.1.
DR AlphaFoldDB; W5PI73; -.
DR SMR; W5PI73; -.
DR STRING; 9940.ENSOARP00000010141; -.
DR PaxDb; 9940-ENSOARP00000010141; -.
DR Ensembl; ENSOART00000010289.1; ENSOARP00000010141.1; ENSOARG00000009451.1.
DR eggNOG; KOG3704; Eukaryota.
DR HOGENOM; CLU_017703_0_0_1; -.
DR OMA; ISLYHTY; -.
DR OrthoDB; 10019at2759; -.
DR Proteomes; UP000002356; Chromosome 8.
DR Bgee; ENSOARG00000009451; Expressed in skeletal muscle tissue of biceps brachii and 20 other cell types or tissues.
DR GO; GO:0008467; F:[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity; IEA:Ensembl.
DR GO; GO:0015015; P:heparan sulfate proteoglycan biosynthetic process, enzymatic modification; IEA:Ensembl.
DR GO; GO:0050819; P:negative regulation of coagulation; IEA:Ensembl.
DR GO; GO:0046596; P:regulation of viral entry into host cell; IEA:Ensembl.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR037359; NST/OST.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR10605:SF46; HEPARAN SULFATE GLUCOSAMINE 3-O-SULFOTRANSFERASE 5; 1.
DR PANTHER; PTHR10605; HEPARAN SULFATE SULFOTRANSFERASE; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR637359-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Transferase {ECO:0000256|RuleBase:RU361155}.
FT DOMAIN 90..334
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
FT ACT_SITE 99
FT /note="For sulfotransferase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-1"
FT BINDING 99..103
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 182
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 190
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 292
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 308..312
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT DISULFID 293..303
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-3"
SQ SEQUENCE 345 AA; 40366 MW; 64AE0C45F7E0CC7D CRC64;
MLFKQQAWLR QKLLVLGSLA VGSLLYLVAR VGSLDRLQPI CPIEGRFGAR GQAEFPLRAL
QFKRGLLHEF RKGNSSKEQV HLHDLVQQLP KAIIIGVRKG GTRALLEMLN LHPAVVKASQ
EIHFFDNDEN YAKGIEWYRK KMPFSYPQQI TIEKSPAYFI TEEVPERIYK MNSSIKLLII
VREPTTRAIS DYTQVLEGKE RKNKTYYKFE KLAIDPNTCE VNTKYKAVRT SIYTKHLERW
LKYFPIEQFH IVDGDRLITE PLPELQLVEK FLNLPPRISQ YNLYFNATRG FYCLRFNIIF
NKCLAGSKGR IHPEVDPSVI TKLRKFFHPF NQKFYQITGR TLNWP
//
