ID W5PIL0_SHEEP Unreviewed; 655 AA.
AC W5PIL0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Anion exchange transporter {ECO:0000256|RuleBase:RU362052};
DE AltName: Full=Solute carrier family 26 member 7 {ECO:0000256|RuleBase:RU362052};
GN Name=SLC26A7 {ECO:0000313|Ensembl:ENSOARP00000010279.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000010279.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000010279.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000010279.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000010279.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|RuleBase:RU362052}.
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DR EMBL; AMGL01112904; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01112905; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01112906; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01112907; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01112908; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01112909; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01112910; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01112911; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01112912; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01112913; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004011892.1; XM_004011843.3.
DR RefSeq; XP_012039544.1; XM_012184154.2.
DR RefSeq; XP_012039545.1; XM_012184155.1.
DR RefSeq; XP_014953418.1; XM_015097932.1.
DR RefSeq; XP_014953419.1; XM_015097933.1.
DR RefSeq; XP_014953420.1; XM_015097934.1.
DR RefSeq; XP_014953421.1; XM_015097935.1.
DR AlphaFoldDB; W5PIL0; -.
DR STRING; 9940.ENSOARP00000010279; -.
DR PaxDb; 9940-ENSOARP00000010279; -.
DR Ensembl; ENSOART00000010431.1; ENSOARP00000010279.1; ENSOARG00000009573.1.
DR eggNOG; KOG0236; Eukaryota.
DR HOGENOM; CLU_003182_9_5_1; -.
DR OMA; LDWSFIQ; -.
DR OrthoDB; 1067648at2759; -.
DR Proteomes; UP000002356; Chromosome 9.
DR Bgee; ENSOARG00000009573; Expressed in thyroid gland and 52 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0098661; P:inorganic anion transmembrane transport; IEA:UniProtKB-UniRule.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR PANTHER; PTHR11814:SF75; ANION EXCHANGE TRANSPORTER; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 65..93
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 203..220
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 226..244
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 304..324
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 344..367
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 379..397
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 403..424
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 445..469
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 492..640
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
SQ SEQUENCE 655 AA; 72142 MW; 7D893D507E424253 CRC64;
MTGAKRKKKS MPWSKMRMPR CEDFKLWCRR RLPILEWATH YSLKESLLPD TVSGMMLAVQ
QVAQGLAFAV LSSVHPVFGL YGSLFPAIIY AIFGMGRHVA TGTFALTSLI SANAVERLVP
LSSQNLTTRS NTSVLGLSDF EMQRISVAAA VSFLGGVIQV AMFVLQLGSA TFLITEPVVS
AMTTGAATHV VTSQAKYLLG MKMPHISGPL GFFYIYAYIF KNIKSVRLEA LLLSLLSIVV
LVLVKELNEQ FKRKIKIVLP VDLVLMIATS LTCYCTNMEN TYGLEVVGHI PKGIPPPRAP
PMNILSAVIT EAFGVALVGY VASLALAQGS AKKFRYSVDD NQEFLAHGLS NVIASFFFCI
PSAAAIGRTA GLYSTGAKTQ VACLISCIFV LIVIYTIGPL LYWLPMCVLA SIIVVGLKGM
LIQFRDLKRY WNVDKIDWGI WVSTYIFTIC FAANVGLLFG VVCTTAIVIG RFPRANTLST
KNMKEMEFKV KTEMDDETLQ RVKIISINNP LVFLNAKKFY NDIMNIIQKE NTGNQPHDEI
RKYEQSTLVS SLSGICNEEA TQPCLNPKCS LILDCSGLTF SDYTGVSMLI EVYMDCKNKS
VDVCLVHCTA SLVKAMKYCG NLDSEKPIFF ESVSAAISNM HLNKNLSILS DHSEI
//
