GenomeNet

Database: UniProt
Entry: W5PJD5_SHEEP
LinkDB: W5PJD5_SHEEP
Original site: W5PJD5_SHEEP 
ID   W5PJD5_SHEEP            Unreviewed;       385 AA.
AC   W5PJD5;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   24-JAN-2024, entry version 52.
DE   SubName: Full=Pregnancy-associated glycoprotein 1-like {ECO:0000313|Ensembl:ENSOARP00000010556.1};
GN   Name=LOC101104869 {ECO:0000313|Ensembl:ENSOARP00000010556.1};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000010556.1, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000010556.1, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000010556.1,
RC   ECO:0000313|Proteomes:UP000002356};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA   Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000010556.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC       {ECO:0000256|ARBA:ARBA00004239}.
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC       {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR   EMBL; AMGL01061599; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01061600; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01061601; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01061602; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01061603; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; W5PJD5; -.
DR   SMR; W5PJD5; -.
DR   PaxDb; 9940-ENSOARP00000010556; -.
DR   Ensembl; ENSOART00000010712.1; ENSOARP00000010556.1; ENSOARG00000009820.1.
DR   eggNOG; KOG1339; Eukaryota.
DR   OMA; ISESYWS; -.
DR   Proteomes; UP000002356; Chromosome 21.
DR   Bgee; ENSOARG00000009820; Expressed in placentome of cotyledonary placenta and 3 other cell types or tissues.
DR   ExpressionAtlas; W5PJD5; baseline.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 6.10.140.60; -; 1.
DR   Gene3D; 2.40.70.10; Acid Proteases; 2.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR001969; Aspartic_peptidase_AS.
DR   InterPro; IPR012848; Aspartic_peptidase_N.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR   PANTHER; PTHR47966:SF49; PEPSIN A-5; 1.
DR   Pfam; PF07966; A1_Propeptide; 1.
DR   Pfam; PF00026; Asp; 1.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; 1.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   3: Inferred from homology;
KW   Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW   ECO:0000256|PIRSR:PIRSR601461-2};
KW   Hydrolase {ECO:0000256|RuleBase:RU000454};
KW   Protease {ECO:0000256|RuleBase:RU000454};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..385
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004870779"
FT   DOMAIN          76..382
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000259|PROSITE:PS51767"
FT   ACT_SITE        94
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   ACT_SITE        275
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   DISULFID        107..112
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT   DISULFID        266..270
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT   DISULFID        308..342
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ   SEQUENCE   385 AA;  43341 MW;  6203352DB926CB47 CRC64;
     MKWLVLLGLV AFSECIVKML GERIPLRRVK TMRNTISGKN ILNSFLKEHT YKLSQISFRG
     SNLTTHPLRN TKDMQYMGNI TIGTPPQEFQ VVFDTGSSEL WVASDFCTSQ VCATNVKFRH
     RQSSTFRPTN KTFRISYGSG RVKAVVVHDT VRIGDLVSTD QPFGITVKEK WLEGRSYDGI
     LGLNYPNLSI SGAIPIFDKL KNEGAISEPV FAFYLSKDER EGSVVMFGGV DHRYYKGELN
     WVPLIEAADW VVHMDRITMR RNVVACSAGC EAVVDTGTSA IEGPERLVKN IQKLIGARQR
     RSQYYVSCSV INTLPSIIFT INGINYPVPG RAYILKDLRG RCFTAFLENK VSSSTETWIL
     GDVFLRLYFS VFDRGNDRIG LARAV
//
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