ID W5PJD5_SHEEP Unreviewed; 385 AA.
AC W5PJD5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE SubName: Full=Pregnancy-associated glycoprotein 1-like {ECO:0000313|Ensembl:ENSOARP00000010556.1};
GN Name=LOC101104869 {ECO:0000313|Ensembl:ENSOARP00000010556.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000010556.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000010556.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000010556.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000010556.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC {ECO:0000256|ARBA:ARBA00004239}.
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR EMBL; AMGL01061599; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01061600; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01061601; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01061602; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01061603; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PJD5; -.
DR SMR; W5PJD5; -.
DR PaxDb; 9940-ENSOARP00000010556; -.
DR Ensembl; ENSOART00000010712.1; ENSOARP00000010556.1; ENSOARG00000009820.1.
DR eggNOG; KOG1339; Eukaryota.
DR OMA; ISESYWS; -.
DR Proteomes; UP000002356; Chromosome 21.
DR Bgee; ENSOARG00000009820; Expressed in placentome of cotyledonary placenta and 3 other cell types or tissues.
DR ExpressionAtlas; W5PJD5; baseline.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 6.10.140.60; -; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR012848; Aspartic_peptidase_N.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF49; PEPSIN A-5; 1.
DR Pfam; PF07966; A1_Propeptide; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 1.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR601461-2};
KW Hydrolase {ECO:0000256|RuleBase:RU000454};
KW Protease {ECO:0000256|RuleBase:RU000454};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..385
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004870779"
FT DOMAIN 76..382
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT ACT_SITE 94
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 275
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT DISULFID 107..112
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT DISULFID 266..270
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT DISULFID 308..342
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 385 AA; 43341 MW; 6203352DB926CB47 CRC64;
MKWLVLLGLV AFSECIVKML GERIPLRRVK TMRNTISGKN ILNSFLKEHT YKLSQISFRG
SNLTTHPLRN TKDMQYMGNI TIGTPPQEFQ VVFDTGSSEL WVASDFCTSQ VCATNVKFRH
RQSSTFRPTN KTFRISYGSG RVKAVVVHDT VRIGDLVSTD QPFGITVKEK WLEGRSYDGI
LGLNYPNLSI SGAIPIFDKL KNEGAISEPV FAFYLSKDER EGSVVMFGGV DHRYYKGELN
WVPLIEAADW VVHMDRITMR RNVVACSAGC EAVVDTGTSA IEGPERLVKN IQKLIGARQR
RSQYYVSCSV INTLPSIIFT INGINYPVPG RAYILKDLRG RCFTAFLENK VSSSTETWIL
GDVFLRLYFS VFDRGNDRIG LARAV
//