ID W5PNF8_SHEEP Unreviewed; 867 AA.
AC W5PNF8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Interleukin 12 receptor subunit beta 2 {ECO:0000313|Ensembl:ENSOARP00000011984.1};
GN Name=IL12RB2 {ECO:0000313|Ensembl:ENSOARP00000011984.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000011984.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000011984.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000011984.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000011984.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 2
CC subfamily. {ECO:0000256|ARBA:ARBA00008921}.
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DR EMBL; AMGL01002181; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01002182; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01002183; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PNF8; -.
DR SMR; W5PNF8; -.
DR STRING; 9940.ENSOARP00000011984; -.
DR PaxDb; 9940-ENSOARP00000011984; -.
DR Ensembl; ENSOART00000012158.1; ENSOARP00000011984.1; ENSOARG00000011173.1.
DR eggNOG; ENOG502QRRE; Eukaryota.
DR HOGENOM; CLU_016653_0_0_1; -.
DR OMA; WAKECTQ; -.
DR Proteomes; UP000002356; Chromosome 1.
DR Bgee; ENSOARG00000011173; Expressed in spleen and 34 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR CDD; cd00063; FN3; 4.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003529; Hematopoietin_rcpt_Gp130_CS.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR010457; IgC2-like_lig-bd.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23036:SF79; INTERLEUKIN-12 RECEPTOR SUBUNIT BETA-2; 1.
DR Pfam; PF06328; Lep_receptor_Ig; 1.
DR SMART; SM00060; FN3; 4.
DR SUPFAM; SSF49265; Fibronectin type III; 4.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS01353; HEMATOPO_REC_L_F2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..867
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004871090"
FT DOMAIN 227..320
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 424..520
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 522..621
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 729..764
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 867 AA; 97387 MW; 8ADCFE61488EA81C CRC64;
MAHTVSGCSL ALIFIIMLLL VKAKIDVCKR GDVTVQPSHV VSLGSAVNIS CSLKPKQGYL
PSSSLNKLIL YKFDRRICVQ HGHSLSFQVT GLPLGTTLFV CKLAYRSRKE IRICGAEISV
GEVVPEQPRN LSCIQKGERG TVTCTWDRGR DTHLYTAYTL QLDGPKNLTW QKQCNDHYCD
HLDLGINLTP ESLESSYTVK VTAINSLGSA SSFPSSFTLL DIVRPLPPWD IRIKFVNASV
NRCTLLWSDE GLVLLNRLRY RPINSRSWNM VNATNAKGRY DLLDLKPFTE YEFQISSKLH
LYKGSWSDWS ESLRIQTPEE EPIGMLDVWY MRQHIDHNRQ QISLFWKNLS LSEARGKILH
YQVTLQEVAG GEITLQNITE DTSWTWVIPR TGTWAVAVSA ANSKGSSLPT RINITDLCGA
ELLAPQQVFA KSEGMDKLMV MWTPPEKAAT AVQKYVVEWR ELHPGGGVQP PLGWLWSPPY
RLSALISENI KPYICYEIRV HALAGDQGGC NSTRGNSQHK APLSGPHINA ISEEKGSVLI
SWDEIPAREQ MGCILHYRIY WKERDSITKQ LFCQIPYRLS PNSHPIDSLQ PRVTYSLWMT
ALTAAGESPQ GNEREFCLQG KANWSAFVAP SIFMAVIMVG ILSMRCFRQN SSLFLLNIFK
NPEMWKEIKD PLITKYNYCW IFPYAIGEEK TQLALDRLLT DWATPEEPEP LVINEVLCRV
TPVFRPPHHP SWSEKGQGVQ RHYTSEEDTE YSASSPPPPR ALTAETGQGV DLYKVLGSKG
PDSKPGNPAS PLTILPVDYL PTHEGYLPSN MNYLPSHEAP ITDPLEELPQ HISLSIFPSS
SLRPLTFSCG EKLTLDQLKM GCGSLML
//
