ID W5PPW2_SHEEP Unreviewed; 2201 AA.
AC W5PPW2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Activating signal cointegrator 1 complex subunit 3 {ECO:0000256|ARBA:ARBA00014590};
GN Name=ASCC3 {ECO:0000313|Ensembl:ENSOARP00000012489.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000012489.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000012489.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000012489.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000012489.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the helicase family.
CC {ECO:0000256|ARBA:ARBA00008708}.
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DR EMBL; AMGL01106815; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01106816; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01106817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01106818; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01106819; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01106820; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01106821; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01106822; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01106823; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01106824; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004011295.1; XM_004011246.3.
DR RefSeq; XP_012038113.1; XM_012182723.2.
DR SMR; W5PPW2; -.
DR STRING; 9940.ENSOARP00000012489; -.
DR PaxDb; 9940-ENSOARP00000012489; -.
DR Ensembl; ENSOART00000012672.1; ENSOARP00000012489.1; ENSOARG00000011627.1.
DR eggNOG; KOG0952; Eukaryota.
DR HOGENOM; CLU_000335_2_1_1; -.
DR OMA; MCSATEF; -.
DR Proteomes; UP000002356; Chromosome 8.
DR Bgee; ENSOARG00000011627; Expressed in embryo and 55 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0010467; P:gene expression; IEA:UniProt.
DR GO; GO:0090304; P:nucleic acid metabolic process; IEA:UniProt.
DR CDD; cd18020; DEXHc_ASCC3_1; 1.
DR CDD; cd18022; DEXHc_ASCC3_2; 1.
DR CDD; cd18795; SF2_C_Ski2; 2.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF13; SEC63 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 2.
DR Pfam; PF02889; Sec63; 2.
DR PIRSF; PIRSF039073; BRR2; 1.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00487; DEXDc; 2.
DR SMART; SM00490; HELICc; 2.
DR SMART; SM00973; Sec63; 2.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 2.
DR PROSITE; PS51194; HELICASE_CTER; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 486..669
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 696..914
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1336..1511
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1544..1739
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT COILED 19..80
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2201 AA; 250715 MW; DA3334931B8E7E3B CRC64;
MALPRLTGAL RSFSNVTKQD NYNEEVADLQ MKRSKLHEQI VGSDLTWMKI VKFLNEKLEK
SEMQRVNEDL KAILQAAKQI VGTDNGKEAI ESAAAFLFKT FHLKDCVGHQ ETKAIKQMFG
PFPSSSATAA CDATNRITSH FCKDSLTALV QMTTDEYGDR VLFGKNLAFS FDMHDLDHFD
ELPINGESQK TISLDYKKFL TDHLQEHSTL NCKPVEKTND SFLWCEVEKY LNATLNEMAE
ATRIEDLCCT LYDMLASVKS GDELQDELFE LLGPDGLELI EKLLQNRITI VDRFLNSSND
HKLQALQDNC KKILGENAKP NYGCQVTIQS EQEKQLMKQY RREEKRMARR EKKAGEDGEA
AEGLLCFDPK ELRIHREQAL MNARNVPILS RQRDTDVEKI RYPHVYDSQA EAMRTSAFIA
GAKMILPEGI QRENNKIYEE VKIPYSEPMP IGFEEKPVYI QDLDEIGQLA FKGMRRLNRI
QSIVFETAYN TNENMLICAP TGAGKTNIAM LTVLHEIRQH FQQGVIKKNE FKIVYVAPMK
ALAAEMTNYF SKRLEPLGIV VKELTGDMQL SKNEILRTQM LVTTPEKWDV VTRKSVGDVA
LSQIVKLLIL DEVHLLHEDR GPVLESIVAR TLRQVESTQS MIRILGLSAT LPNYLDVATF
LHVNPCIGLF FFDGRFRPVP LGQTFLGVKS ANKVQQLNNM DEVCYESVLK QVKAGHQVMV
FVHARNATVR TAMSLIERAK NNGHISYFLP TQGPEYGHAE KQVQKSRNRQ VRELFPDGFS
IHHAGMLRQD RNLVESLFSN GHIKVLVCTA TLAWGVNLPA HAVIIKGTQI YAAKRGSFVD
LGILDVMQIF GRAGRPQFDK FGEGIIITTH DKLSHYLSLL TQQNPIESQF LESLADNLNA
EIALGTVTNV EEAVKWISYT YLYVRMRANP LVYGISHKAY QIDPTLAKHR EQLVIEVGRK
LDKARMIRFE ERTGYFSSTD LGRTASHYYI KYNTIETFNE LFDAHKTESD IFAIVSKAEE
FDQIKVREEE IEELDALLSN FCELSAPGGV ENSYGKINIL LQTYISRGEV DSFSLISDSA
YVAQNAARIV RALFEIALRK RWPAMTYRLL NLSKVIDKRL WGWTSPLRQF SVLPPHILTR
LEEKNLTVDK LKDMRKDEIG HILHHVNIGL KVKQCVHQIP SVTMEASIQP ITRTVLRVTL
SISPDFSWND QVHGTVGEPW WIWVEDPTND HIYHSEYFLV LKKQVISKEA QLLVFTIPIF
EPLPSQYYIR AVSDRWLGAE AVCIINFQHL ILPERHPPHT ELLDLQPLPI TALGCEAYEA
LYNFSHFNPV QTQIFHTLYH TDCNVLLGAP TGSGKTVAAE LAIFRVFNKY PASKAVYIAP
LKALVRERMD DWKVRIEEKL GKKVIELTGD VTPDMKSIAK ADLIVTTPEK WDGVSRSWQN
RNYVKQVTIL IIDEIHLLGE ERGPVLEVIV SRTNFISSHT EKPVRIVGLS TALANARDLA
DWLNIRQMGL FNFRPSVRPV PLEVHIQGFP GQHYCPRMAS MNKPTFQAIR SHSPAKPVLI
FVSSRRQTRL TALELIAFLA TEEDPKQWLN MDEREMENII GTIRDSNLKL TLAFGIGMHH
AGLHERDRKT VEELFVNCKI QVLIATSTLA WGVNFPAHLV IIKGTEYYDG KTRRYVDFPI
TDVLQMMGRA GRPQFDDQGK AVILVHDIKK DFYKKFLYEP FPVESSLLGV LSDHLNAEIA
GGTITSKQDA MDYITWTYFF RRLIMNPSYY NLSDVSHDSV NKFLSNLVEK SLVELEHSYC
IEIGEDNRSI EPLTYGRIAS YYYLKHQTVK MFKERLKPEC GTEELLSILS DAEEYTDLPV
RHNEDHMNSE LAKCLPLESN PHSFDSPHTK AHLLLQAHLS RTMLPCPDYD TDTKTVLDQA
LRVCQAMLDV AAHQGWLVTV LNITNLVQMV IQGRWLKDSS LLTIPHIENH HLHIFRKWSP
GVKGPRAGYH GSIECLPELI HACAGKDHVF SSMIEKELPA PKMKQAWNFL SHLPVIDVGL
SVKGWWDDAT EGHDEVSITT VASDKRSDNR WVRLHADQEY VLQVSLQRVS LGFHKGKQDS
HAVTPRFPKS KDEGWFLILG EVDKRELIAL KRVGYVRSHH VVSISFYTPE VPGRYIYTLY
FMSDCYLGLD QQYDIHLHVT PASISAQADE ISDALTDLKV K
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