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Database: UniProt
Entry: W5PRE1_SHEEP
LinkDB: W5PRE1_SHEEP
Original site: W5PRE1_SHEEP 
ID   W5PRE1_SHEEP            Unreviewed;      1013 AA.
AC   W5PRE1;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-SEP-2017, entry version 30.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000013020};
GN   Name=KCNH1 {ECO:0000313|Ensembl:ENSOARP00000013020};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000013020, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000013020, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000013020};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000013020}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOARP00000013020}.
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DR   EMBL; AMGL01022736; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01022737; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01022738; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01022739; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01022740; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01022741; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01022742; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01022743; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01022744; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01022745; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSOART00000013209; ENSOARP00000013020; ENSOARG00000012144.
DR   GeneTree; ENSGT00760000118772; -.
DR   OMA; KGEDWNK; -.
DR   OrthoDB; EOG091G0OXR; -.
DR   Proteomes; UP000002356; Chromosome 12.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR030170; EAG1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003949; K_chnl_volt-dep_EAG.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   PANTHER; PTHR10217:SF564; PTHR10217:SF564; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF13426; PAS_9; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   PRINTS; PR01464; EAGCHANNEL.
DR   SMART; SM00100; cNMP; 1.
DR   SMART; SM00086; PAC; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   TIGRFAMs; TIGR00229; sensory_box; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS50113; PAC; 1.
DR   PROSITE; PS50112; PAS; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Ion channel {ECO:0000256|SAAS:SAAS00091826};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00807593};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00807732};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00807568};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00807693}.
FT   TRANSMEM    231    249       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    388    412       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    461    478       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    490    514       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       54    106       PAS. {ECO:0000259|PROSITE:PS50112}.
FT   DOMAIN      105    157       PAC. {ECO:0000259|PROSITE:PS50113}.
FT   DOMAIN      621    708       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
SQ   SEQUENCE   1013 AA;  113971 MW;  8292662D77980DC5 CRC64;
     MDQNGKKRLW PEEVFIGRNN IPKDGTCKSG IEPRKSLGDT NFVLGNAQIV DWPIVYSNDG
     FCKLSGYHRA EVMQKSSTCS FMYGELTDKD TIEKVRQTFE NYEMNSFEIL MYKKNRTPVW
     FFVKIAPIRN EQDKVVLFLC TFSDITAFKQ PIEDDSCKGW GKFARLTRAL TSSRGVLQQL
     APSVQKGENV HKHSRLAEVL QLGSDILPQY KQEAPKTPPH IILHYCVFKT TWDWIILILT
     FYTAILVPYN VSFKTRQNNV AWLVVDSIVD VIFLVDIVLN FHTTFVGPAG EVISDPKLIR
     MNYLKTWFVI DLLSCLPYDV INAFENVDEV SAFMGDPGKI GFADQIPPPL EGRESQGISS
     LFSSLKVVRL LRLGRVARKL DHYIEYGAAV LVLLVCVFGL AAHWMACIWY SIGDYEIFDE
     DTKTIRNNSW LYQLAMDTGT PYQFNGSGSG KWEGGPSKNS VYISSLYFTM TSLTSVGFGN
     IAPSTDIEKI FAVAIMMIGS LLYATIFGNV TTIFQQMYAN TNRYHEMLNS VRDFLKLYQV
     PKGLSERVMD YIVSTWSMSR GIDTEKVLQI CPKDMRADIC VHLNRKVFKE HPAFRLASDG
     CLRALAPAFR LWPRGCLRAL AMEFQTVHCA PGDLIYHAGE SVDSLCFVVS GSLEVIQDDE
     VVAILGKGDV FGDVFWKEAT LAQSCANVRA LTYCDLHVIK RDALQKVLEF YTAFSHSFSR
     NLILTYNLRK RIVFRKISDV KREEEERMKR KNEAPLILPP DHPVRRLFQR FRQQKEARLA
     AERGGRDLDD LDVEKGSVLT EHSHHGLAKA SVVTVRESPA PPVAFPAAAP AGLDHARLQA
     PGAEGLGPKA GGADCAKRKG WARFKDACGK TEDWSKVSKA ESMETLPERT KAAGEATLKK
     TDSCDSGITK SDLRLDNVGE ARSPQDRSPI LAEVKHSFYP IPEQTLQAAV LEVKLELKED
     IKALSTKMTS IEKQLSEILR IVTSRRSSQS PQELFEISRP QSPESERDIF GAS
//
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