ID W5PS76_SHEEP Unreviewed; 956 AA.
AC W5PS76;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=UNC-45/Cro1/She4 central domain-containing protein {ECO:0000259|Pfam:PF11701};
GN Name=UNC45A {ECO:0000313|Ensembl:ENSOARP00000013305.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000013305.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000013305.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000013305.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000013305.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC {ECO:0000256|ARBA:ARBA00004556}.
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DR EMBL; AMGL01041470; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PS76; -.
DR SMR; W5PS76; -.
DR STRING; 9940.ENSOARP00000013305; -.
DR PaxDb; 9940-ENSOARP00000013305; -.
DR Ensembl; ENSOART00000013501.1; ENSOARP00000013305.1; ENSOARG00000012410.1.
DR eggNOG; KOG4151; Eukaryota.
DR HOGENOM; CLU_007331_0_0_1; -.
DR OMA; LDQKHED; -.
DR Proteomes; UP000002356; Chromosome 18.
DR Bgee; ENSOARG00000012410; Expressed in rumen and 52 other cell types or tissues.
DR ExpressionAtlas; W5PS76; baseline.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR024660; UCS_central_dom.
DR PANTHER; PTHR45994; FI21225P1; 1.
DR PANTHER; PTHR45994:SF3; PROTEIN UNC-45 HOMOLOG A; 1.
DR Pfam; PF13432; TPR_16; 1.
DR Pfam; PF13181; TPR_8; 1.
DR Pfam; PF11701; UNC45-central; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 1.
PE 4: Predicted;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Myogenesis {ECO:0000256|ARBA:ARBA00022541};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 91..124
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 345..504
FT /note="UNC-45/Cro1/She4 central"
FT /evidence="ECO:0000259|Pfam:PF11701"
SQ SEQUENCE 956 AA; 104246 MW; E1E7F7727C369A62 CRC64;
MTVSGPGTPP SPSRPAASSV EQLRKDGNEL FKCGDYEGAL TAYTQALGLS ATPQDQAILH
RNRAACHLKL EDYEKAETEA TKAIEKDGGD VKALYRRSQA LEKLGRLDQA VLDLQRCVSL
EPKNKVFQEA LRNIAGQIQE KVRYMSSTDA KVEQMFQILL DPQEKGTEKK QKASQNLVVL
AREDAGAEKI FRSNGVQLLQ RLLDTGEPDL MLAALRTLVG ICSEHQSRTV ATLSVLGTRR
VVSMLGVENQ AVSLAACHLL QVMFDALKEG VKKGFRGKEG AIIVDPAREL KVLISNLLEL
LTEVGVSGQG RDNALTLLIK MVPRKSPKDP NNSLTLWVID QGLKKILEVG GSVQDPPGEL
TVTANSRMSA SILLSKLFDD LKCDAERENF HRLCENYIKS WFEGHGLAGK LRAIQTVSCL
LQGPCDAGNR ALELNGVMES VIALCASEQE EEQLVAVEAL IHAAGKAKRA SFITANGVSL
LKDLYKRSEK DSIRIRALVG LCKLGSAGGT DFSMKQFAEG STLKLAKQCR KWLCNDQMDV
GTRRWAVEGL AYLTFDADVK EEFVEDAAAL KALFQLSKSE ERSVLFAVAS ALVNCTNSYD
YEEPDPKMVE LAKYAKQHVP EQHPKDKPSF VRARVKKLLA AGVVSAMTCM VKTESPVLTS
SCRELLSRVF LALVEEVEDR GTVVAQGGGK ALLPLALEGT DVGQTKAAQA LAKLTITSNP
EMTFPGERIY EVVRPLVSLL HLNCSGLQNF EALMALTNLA GISERLRQKI LKEKAVPMIE
GYMFEEHEML RRAATECMCN LAMSKEVQDL FEATGNDRLK LLVLYSGEED AGWLGRPAAG
GLAMLTSMRP SLCSRIPQVT THWLEILQAL LLSPSQELQH RGAVVVLNMV EASREIASTL
MESEVLEILS VLAKDKESPV TRAATACLGK AVEYGLIKPS QDGKCGTQVG ALSAGR
//
