ID W5PTD4_SHEEP Unreviewed; 655 AA.
AC W5PTD4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=non-specific protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011903};
DE EC=2.7.10.2 {ECO:0000256|ARBA:ARBA00011903};
GN Name=TNK1 {ECO:0000313|Ensembl:ENSOARP00000013715.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000013715.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000013715.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000013715.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000013715.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AMGL01018029; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PTD4; -.
DR SMR; W5PTD4; -.
DR STRING; 9940.ENSOARP00000013715; -.
DR PaxDb; 9940-ENSOARP00000013715; -.
DR Ensembl; ENSOART00000013920.1; ENSOARP00000013715.1; ENSOARG00000012804.1.
DR eggNOG; KOG0199; Eukaryota.
DR HOGENOM; CLU_000288_7_39_1; -.
DR OMA; REVMEPG; -.
DR Proteomes; UP000002356; Chromosome 11.
DR Bgee; ENSOARG00000012804; Expressed in abomasum and 52 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR CDD; cd09539; SAM_TNK-like; 1.
DR CDD; cd14328; UBA_TNK1; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR049587; TNK-like_SAM.
DR PANTHER; PTHR24418:SF263; NON-RECEPTOR TYROSINE-PROTEIN KINASE TNK1; 1.
DR PANTHER; PTHR24418; TYROSINE-PROTEIN KINASE; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 2.
DR PRINTS; PR00109; TYRKINASE.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 116..382
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 440..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..471
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 481..495
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 148
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 655 AA; 72096 MW; 557AED38FEA06794 CRC64;
MLPEAGSLWL LRLLRDLQLA QFYRPILEEL NVTRPEHFDF VRAEDLDGIG MGRPAQRRLA
EALKRHRSGL KSKNWVYKIL GGFASGQKET TPPSDSLPSL PEPDGRLKCL IPDRAVCRGE
LLGSGCFGMV HRGLWTLPSG QTVPVAVKSL RVGPEGPEGT ELEDFLREVS VMMNLEHPHV
LRLHGLVLGQ PLQMVMELAP LGSLHARLTA PAPTPPLALA LLCLFLRPLH HGWPPPHPLC
MVRTWAVGQD LRNAGPRGAL RGRAQWQVGA PGTHPVHTSG PLQLRFHRCA PESLRHGAFS
SASDVWMYGV TLWEMFAGGE EPWAGVPPYL ILQRLEKDRA RLPRPPLCSR ALYTLALRCW
AYHPADRPTF SDLEGLLQEA WPPEGRCVRE VMEPGALRME PGDPITIIEG SPDSTTWKGQ
NGRTFKVGSF AASAVTLVDL PPPRPILRGT PARGERHQRN ADGDRGKAKL QDAPQARGQR
RNVALQRTKG ISKSLESVLS LGPRPTGGGS SPPELRHART GPQGPPGRSP RLPMAASSSQ
PPRERPPWPK REFPHSHPVG APGASKATIP SGGPLSDPEL QRRVMEVELS VHGVTYQECQ
AALRATGGDV VSAIRNLKVE QLFYLSSWSR ADCRRILERY QWDLSAASRY VLARP
//
