ID W5PV56_SHEEP Unreviewed; 650 AA.
AC W5PV56;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000014338.1};
GN Name=CAPN5 {ECO:0000313|Ensembl:ENSOARP00000014338.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000014338.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000014338.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000014338.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000014338.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C2 family.
CC {ECO:0000256|ARBA:ARBA00007623}.
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DR EMBL; AMGL01032559; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PV56; -.
DR SMR; W5PV56; -.
DR STRING; 9940.ENSOARP00000014338; -.
DR PaxDb; 9940-ENSOARP00000014338; -.
DR Ensembl; ENSOART00000014547.1; ENSOARP00000014338.1; ENSOARG00000013374.1.
DR eggNOG; KOG0045; Eukaryota.
DR HOGENOM; CLU_010982_3_2_1; -.
DR OMA; DICENPR; -.
DR Proteomes; UP000002356; Chromosome 15.
DR Bgee; ENSOARG00000013374; Expressed in pylorus and 51 other cell types or tissues.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04046; C2_Calpain; 1.
DR CDD; cd00214; Calpain_III; 1.
DR CDD; cd00044; CysPc; 1.
DR Gene3D; 2.60.120.380; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR033884; C2_Calpain.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR033883; C2_III.
DR InterPro; IPR022684; Calpain_cysteine_protease.
DR InterPro; IPR022682; Calpain_domain_III.
DR InterPro; IPR022683; Calpain_III.
DR InterPro; IPR036213; Calpain_III_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR PANTHER; PTHR10183; CALPAIN; 1.
DR PANTHER; PTHR10183:SF402; CALPAIN-5; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF01067; Calpain_III; 1.
DR Pfam; PF00648; Peptidase_C2; 1.
DR PRINTS; PR00704; CALPAIN.
DR SMART; SM00239; C2; 1.
DR SMART; SM00720; calpain_III; 1.
DR SMART; SM00230; CysPc; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00239};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU00239}; Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807, ECO:0000256|PROSITE-
KW ProRule:PRU00239}.
FT DOMAIN 32..352
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT DOMAIN 509..624
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT ACT_SITE 90
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 261
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 293
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
SQ SEQUENCE 650 AA; 74010 MW; 2EC29089229A97DB CRC64;
PGAAITMFSC VKPYEDQNYS ALKRACLRRK VLFEDPNFPA TDDSLYYKGS PGPTVRWKRP
KGVLPSPGHL RLFVDGISSH DLHQGQVGNC WFVAACSSLA SRESLWQKVI PDWKEQEWDP
EKPNAYAGIF HFHFWRFGEW VDVVIDDRLP TVNNQLIYCH SSSRNEFWCA LVEKAYAKSH
RCYQALDGGN TADALVDFTG GVSEPIDLTE GDFANDEAKR NQLFERVLKV HSRGGLISAS
IKAVTAADME ARLACGLVKG HAYAITDVRK VRLGHGLLAF FKSEKLDMIR LRNPWGEREW
IGPWSDTSEE WQKVSKSERE KLGVTVQDDG EFWMTFEDLC RYFTDIIKCR LINTSYLSIH
KTWEEARLRG AWTRHEDPLQ NRSGGCINHK DTFFQNPQQY IFDVKKPEDE VLICIQQRPK
QSTRRDGKGE NLAIGFDIYK VEENRQYRMH SLQHRAASSI YINSRSVFLR TEQPEGRYVI
IPTTFEPGHT GEFLLRVFTD VPANCRELRL DEPPRTCWSS LCGYPQQVTQ VHVLGAAGLK
DSPTGANSYV IIKCEGDKVR SAVQKGTSTP EYDVKGVFYR KKPSQPITVQ IWNHRVLKDE
FLGQVHLKAN ADDLQALHTL HLRDRNSRQP SDLPGTVAVR VLSSASLTAV
//
