ID W5PW20_SHEEP Unreviewed; 439 AA.
AC W5PW20;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=SET domain-containing protein {ECO:0000259|PROSITE:PS50280};
GN Name=SETD4 {ECO:0000313|Ensembl:ENSOARP00000014653.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000014653.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000014653.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000014653.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000014653.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AMGL01012354; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01012355; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004003445.1; XM_004003396.3.
DR RefSeq; XP_011960250.1; XM_012104860.2.
DR RefSeq; XP_011960256.1; XM_012104866.2.
DR RefSeq; XP_011960264.1; XM_012104874.2.
DR RefSeq; XP_011960276.1; XM_012104886.2.
DR AlphaFoldDB; W5PW20; -.
DR SMR; W5PW20; -.
DR STRING; 9940.ENSOARP00000014653; -.
DR PaxDb; 9940-ENSOARP00000014653; -.
DR Ensembl; ENSOART00000014868.1; ENSOARP00000014653.1; ENSOARG00000013659.1.
DR eggNOG; KOG1337; Eukaryota.
DR HOGENOM; CLU_029120_3_0_1; -.
DR OMA; ISHMKDE; -.
DR OrthoDB; 11215at2759; -.
DR Proteomes; UP000002356; Chromosome 1.
DR Bgee; ENSOARG00000013659; Expressed in embryo and 55 other cell types or tissues.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd19177; SET_SETD4; 1.
DR Gene3D; 3.90.1420.10; Rubisco LSMT, substrate-binding domain; 1.
DR Gene3D; 3.90.1410.10; set domain protein methyltransferase, domain 1; 1.
DR InterPro; IPR015353; Rubisco_LSMT_subst-bd.
DR InterPro; IPR036464; Rubisco_LSMT_subst-bd_sf.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR016852; SET_MeTrfase.
DR InterPro; IPR044429; SETD4_SET.
DR PANTHER; PTHR13271:SF163; SET DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR13271; UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE; 1.
DR Pfam; PF09273; Rubis-subs-bind; 1.
DR Pfam; PF00856; SET; 1.
DR PIRSF; PIRSF027158; Lys_MTase_YDR198C_prd; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 48..273
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
SQ SEQUENCE 439 AA; 50146 MW; 2EA886FABD1B0DAF CRC64;
MKNGGGRTSR IRRRKLFRSS ESRGVNESYK PEFIELKKWL KDRRFEDATL IPARFPGTGR
GLMSKTSLQE GQTIISLPES CLLTTDTVIR SYLGAYIAKW QPPPSPLLAL CTFLVSEKHA
GDRSPWKPYL EVLPKAYTCP VCLEPEVVNL LPNPLKTKAW EQRSHVQEFF SSSRGFFSSL
QPLFSEAIET IFSYRALRWA WCTVNTRAVY MKRPPQLCLS PEPDTCALAP YLDLLNHSPD
VQVKAAFNEE TRCYEIRTAT RCGKHKEVFI CYGPHDNHRL LLEYGFVSVS NPHACVYVSK
DILVKYLPST AKQMNKKISI LEDHDFIENL TFGWDGPSWR LLTALKLLCL EAEEFMCWKK
VLLGEIISDT NEKTSLDVAQ KICCYFIEET HAVLRKVSRM KDEVALMNQL TLVETLRTEE
LKILQASAKA LTALQTAFT
//
