ID W5PW39_SHEEP Unreviewed; 539 AA.
AC W5PW39;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Lamin B2 {ECO:0008006|Google:ProtNLM};
GN Name=LMNB2 {ECO:0000313|Ensembl:ENSOARP00000014672.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000014672.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000014672.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000014672.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000014672.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus lamina {ECO:0000256|ARBA:ARBA00024186}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; AMGL01091689; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01091690; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01091691; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9940.ENSOARP00000014672; -.
DR PaxDb; 9940-ENSOARP00000014672; -.
DR Ensembl; ENSOART00000014889.1; ENSOARP00000014672.1; ENSOARG00000013683.1.
DR eggNOG; KOG0977; Eukaryota.
DR HOGENOM; CLU_012560_9_2_1; -.
DR OMA; EMTQMRD; -.
DR Proteomes; UP000002356; Chromosome 5.
DR Bgee; ENSOARG00000013683; Expressed in embryo and 55 other cell types or tissues.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005635; C:nuclear envelope; IEA:UniProt.
DR GO; GO:0005652; C:nuclear lamina; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 2.60.40.1260; Lamin Tail domain; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR001322; Lamin_tail_dom.
DR InterPro; IPR036415; Lamin_tail_dom_sf.
DR PANTHER; PTHR45721; LAMIN DM0-RELATED; 1.
DR PANTHER; PTHR45721:SF2; LAMIN-B2; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF00932; LTD; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 1.
DR SUPFAM; SSF74853; Lamin A/C globular tail domain; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
DR PROSITE; PS51841; LTD; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023289};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Prenylation {ECO:0000256|ARBA:ARBA00023289};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 1..318
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT DOMAIN 380..497
FT /note="LTD"
FT /evidence="ECO:0000259|PROSITE:PS51841"
FT REGION 45..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 318..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 500..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 114..141
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 173..289
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 45..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 539 AA; 59987 MW; C45FA3B20C7DF02E CRC64;
SPQVSGIKTL YEAELADARR VLDETARDRA CLQIEMGKLR ADLEEATKSA KKREGELTVA
QGRGRDPGSV FPPSEGGLAA PSTPRGRLGA RDPQGPHAAA DSAEDGHAVA KKQLEKETLM
RVDLENRCQS LQEELAFRKD VFEEEVRETR RRHERRLVEV DSSRQQEYDF KMAQALEELR
AQHDEQVRLY RLELEQTYQA KLDNAKLSSD QNDKAASAAR EELKEARMRV ESLSYQLSGL
QKQASAAEDR IRELEETVAG ERDKFRKMLD AKEREMMEVR DMMQQQLAEY QELLDVKLAL
DMEISAYRKL LEGEEERPKL CAHPPRATPL XQKPATAPTS APTPGPRGGS KRKRLEVEEP
PGTGSSGLGS SSSTSSGSSF HLAQQASASG SVSIEEIDLE GRFVQLKNSS DKDQSLGNWR
IKRQVLEGEE ISYKFTPKYV LRAGQTVTVW AAGAGVAHSP PSTLVWKSQN SWGTGESFRT
TLVNADGEEV AMRTVKQSSV VRETENGEEG EDEAAEFGEE DLFHQQGDPR TTSRGCRVM
//
