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Database: UniProt
Entry: W5PXD5_SHEEP
LinkDB: W5PXD5_SHEEP
Original site: W5PXD5_SHEEP 
ID   W5PXD5_SHEEP            Unreviewed;      1804 AA.
AC   W5PXD5;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   07-JUN-2017, entry version 24.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN4A {ECO:0000313|Ensembl:ENSOARP00000015119};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000015119, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000015119, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000015119};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000015119}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOARP00000015119}.
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DR   EMBL; AMGL01018940; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01018941; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSOART00000015339; ENSOARP00000015119; ENSOARG00000014087.
DR   GeneTree; ENSGT00830000128242; -.
DR   OMA; GNDTWYG; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000002356; Chromosome 11.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR008052; Na_channel_a4su_mammal.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01665; NACHANNEL4.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    132    151       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    196    215       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    227    248       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    254    274       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    406    434       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    562    580       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    592    615       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    627    651       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    672    700       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    730    747       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    759    785       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1018   1036       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1057   1079       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1085   1105       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1134   1160       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1254   1277       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1336   1354       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1366   1384       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1396   1416       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1453   1481       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1554   1580       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      136    439       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      563    789       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      799   1012       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1016   1285       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1335   1590       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED       30     53       {ECO:0000256|SAM:Coils}.
FT   COILED      441    475       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1804 AA;  203875 MW;  5203D031203392FD CRC64;
     MANASLPTVV PLGPESLRPF TRESLAAIER RVLEEEARQL RNKQMEVEET ERKPRSDMEA
     GKNLPLIYGD PPPEVIGIPL EDLDPYYSDK KTFIVLNKGK SIFRFSATPA LYLLSPFSIV
     RRCAIKVLIH SYPGGMFIMI TILTNCVFMT MSDPPSWSKH VEYTFTGIYT FESLIKILAR
     GFCIDDFTFL RDPWNWLDFS VIMMAYLTEF VDLGNISALR TFRVLRALKT ITVIPGLKTI
     VGALIQSVKK LSDVMILTVF CLSVFALVGL QLFMGNLRQK CVRWPPPFND TNTTWDGNNT
     WDGNNTWDGQ ESWASNYTFD WDAYINDEGN FYFLEGSNDA LLCGNSSDAG HCPEGYECIK
     AGRNPNYGYT SYDTFSWAFL ALFRLMTQDY WENLFQLTLR AAGKTYMIFF VVIIFLGSFY
     LINLILAVVA MAYAEQNEAT LAEDQEKEEE FQQMLEKFKK QQEELEKAKA AQALEGGEVD
     GDPAHSKDCN GSLDASAGEK GPPRPSCGTD SGISDAMEEL EEAHQKCPPW WYKCSHKVLI
     WNCCTPWVKF KKIVHLIVMD PFVDLGITIC IVLNTLFMAM EHYPMTEHFD SVLNVGNLVF
     TGIFTAEMVL KLIAMDPYEY FQQGWNIFDS IIVTLSLVEL GLANVQGLSV LRSFRLLRVF
     KLAKSWPTLN MLIKIIGNSV GALGNLTLVL AIIVFIFAVV GMQLFGKSYK ECVCKIAADC
     SLPRWHMHDF FHSFLIVFRI LCGEWIETMW DCMEVAGQAM CLTVFLMVMV IGNLVVLNLF
     LALLLSSFSA DSLAASDEDG EMNNLQIAIA RIKWGIGFAK AFLVGLLHGK VLSPKVIMLS
     LGSIGEAGEA GEAPESAPED EKKEPPPEED GKDLKKDNHI LNHMGLADGP PPSIELDHLN
     FINNPYLTIH VPIASEESDL EMPTEEETDT FSEPEDVKVS LQPLDGNSSV CSTADYKPPE
     DDPEEQAEEN PEGEQPEECF TEACVQRFPF LYVDISQGRG KKWWTLRRAC FKIVEHNWFE
     TFIVFMILLS SGALAFEDIH IEQRRVIRTI LEYADKVFTY IFILEMLLKW VAYGFKVYFT
     NAWCWLDFLI VDVSIISLVA NWLGYSELGP IKSLRTLRAL RPLRALSRFE GMRVVVNALL
     GAIPSIMNVL LVCLIFWLIF SIMGVNLFAG KFYYCINTTT SERFDISEVN NKSECESLMH
     TGQVRWLNVK VNYDNVGLGY LSLLQVATFK GWKPTPHARP KEEQPQYEVN LYMYLYFVIF
     IIFGSFFTLN LFIGVIIDNF NQQKKKFGGK DIFMTEEQKK YYNAMKKLGS KKPQKPIPRP
     QNKVQGMVYD LVTKQAFDIT IMILICLNMV TMMVETDDQS QLKVDILYNI NMVFIIIFTG
     ECVLKMLALR QYYFTVGWNI FDFVVVILSI VGLALSDLIQ KYFVSPTLFR VIRLARIGRV
     LRLIRGAKGI RTLLFALMMS LPALFNIGLL LFLVMFIYSI FGMSNFAYVK KESGIDDMFN
     FETFGNSIIC LFEITTSAGW DGLLNPILNS GPPDCDPNLE NPGTSIRGDC GNPSIGICFF
     CSYIIISFLI VVNMYIAIIL ENFNVATEES SEPLGEDDFE MFYETWEKFD PDATQFIDYS
     RLSDFVDTLQ EPLRIAKPNK IKLITLDLPM VPGDKIHCLD ILFALTKEVL GDSGEMDALK
     ETMEEKFMAA NPSKVSYEPI TTTLKRKHEE VCAIKIQRAY RRHLLQRSVK GGGDGAPEKE
     GLIADTMSKM YGPDNGNSGV RAPRGQRVSR LAGGGEVAQP RRTPLVPAAE GARALRPGLT
     QLPG
//
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