ID W5PZ29_SHEEP Unreviewed; 1217 AA.
AC W5PZ29;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Tripartite motif containing 66 {ECO:0008006|Google:ProtNLM};
GN Name=TRIM66 {ECO:0000313|Ensembl:ENSOARP00000015715.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000015715.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000015715.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000015715.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000015715.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AMGL01032039; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PZ29; -.
DR SMR; W5PZ29; -.
DR STRING; 9940.ENSOARP00000015715; -.
DR PaxDb; 9940-ENSOARP00000015715; -.
DR Ensembl; ENSOART00000015947.1; ENSOARP00000015715.1; ENSOARG00000014647.1.
DR eggNOG; KOG2177; Eukaryota.
DR HOGENOM; CLU_005817_1_0_1; -.
DR OMA; PQDFQWP; -.
DR Proteomes; UP000002356; Chromosome 15.
DR Bgee; ENSOARG00000014647; Expressed in pituitary gland and 50 other cell types or tissues.
DR ExpressionAtlas; W5PZ29; baseline.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd19811; Bbox1_TRIM66; 1.
DR CDD; cd19794; Bbox2_TRIM66-like; 1.
DR CDD; cd05502; Bromo_tif1_like; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR003649; Bbox_C.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR037372; TRIM66_Bbox1_Znf.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45915; TRANSCRIPTION INTERMEDIARY FACTOR; 1.
DR PANTHER; PTHR45915:SF7; TRIPARTITE MOTIF-CONTAINING PROTEIN 66; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR SMART; SM00502; BBC; 1.
DR SMART; SM00336; BBOX; 2.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50119; ZF_BBOX; 2.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 22..57
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 82..123
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 971..1018
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1059..1131
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 392..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 522..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 669..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 729..785
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 938..964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1154..1204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 152..208
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 424..445
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..462
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..587
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 677..692
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 729..745
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1188..1204
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1217 AA; 133976 MW; 6873E265504DFCA7 CRC64;
VYITRDVTEH FLLQCFSSGQ SKMVRNCSEC KEKRAAHILC TYCNRWLCSS CTEEHQHGPA
PGGPLFSRTQ KGSPGVNGGS GDFALYCPLH TQEILKLFCE TCDVLTCHSC LMVEHKEHRC
RHLEEVLQNQ RMLLESVTTQ VAHKKSSLQT SAKQIEDRIF EVKHQHRKVE NQIKMAKMVL
MNELNKQANG LIEELEGITN ERKRKLEQQL QSIMVLNRQF EHVQNFINWA VCSKTSIPFL
FSKELIVFQM QRLLETNCNT DPGSPWSIRF TWEPNFWTKQ LASLGCITTE GGQLSRADTP
AYGGLQGPSS FYQSHQSPVA QQETLSHPSH KFQSPAICSS SVCCSHCSPV SPSLKGQVPP
PSIHPVHSFR QPSEMVPHQL GSLQCSTLLP REKELPCNPH PPKPSIQVQF GHHQKLKLSH
FQPPPQQQLP PPPPPPPPLP PQHLSGPSPY LASSQHESPP GPACSQNMDI MHHKFELEEM
QKDLELLLQA QQPSLQLSQT KSPQHLQQTI VGQINYIVRQ PAPVQSQSQE DTVQAADEPP
ASEGPKPPTL PLDKNTAANL PQASGEETPH SVPALDSSVQ HSSPNVVRKH STSLSIMGFS
NTLEMELSST RLARTLEPQM QSTSSLTAAP PQVMPQVVPS LLSGPPPTMS SLASGQNQAV
PSLTASHLPA MPSLVRGPPQ STPSLMSDPS PAIASLASDR SQAGPNLMSG PTHTVPSLAT
CPLQSVLPAS DVQPETGSGS SPGSGRTAGG LCPGDGTDPS LGNALCKMES EESTRFTDSL
GQGPTAAALD ASKDLSIPSD LEEPINLSVK KPALVPVVNT SVALQQHRSP REYENFEQGA
LGLNTKGNQS IRPFSNEPKI PYVRLERLKI CAASSGEMPV FKLKPQKNDQ DGSFLLIIEC
GAESSSMSIK VSEDHLPDAI QAPNLGGRKV TVTSLAGQQP PEVESASPEE HRLIPRTPGA
KKGPPVPIEN EDFCAVCLNG GELLCCDRCP KVYHLSCHLP ALLSFPGGDW VCTLCRSLTQ
PEMEYDCENA RFSQPGVRAP PGLSIYDQKK CEKLVLSLCC NSLSLPFHEP VSPLARHYYQ
IIKRPMDLSI IRRKLQKKDP AHYTTPEEVV SDVRLMFWNC AKFNYPDSEV AEAGRCLEVF
FEGWLKEIYP EKRFAQPQQE DSDSEEVSSE SGYSTPQGFP WPHYMQEGIQ PKRRRRHMEN
ERAKRVSFRL ANSISQV
//
