ID W5Q146_SHEEP Unreviewed; 339 AA.
AC W5Q146;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=L-serine ammonia-lyase {ECO:0000256|ARBA:ARBA00012093};
DE EC=4.3.1.17 {ECO:0000256|ARBA:ARBA00012093};
GN Name=SRR {ECO:0000313|Ensembl:ENSOARP00000016432.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000016432.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000016432.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000016432.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000016432.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-serine = NH4(+) + pyruvate; Xref=Rhea:RHEA:19169,
CC ChEBI:CHEBI:15361, ChEBI:CHEBI:28938, ChEBI:CHEBI:33384; EC=4.3.1.17;
CC Evidence={ECO:0000256|ARBA:ARBA00001161};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- SIMILARITY: Belongs to the serine/threonine dehydratase family.
CC {ECO:0000256|ARBA:ARBA00010869}.
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DR EMBL; AMGL01017896; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01017897; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5Q146; -.
DR SMR; W5Q146; -.
DR STRING; 9940.ENSOARP00000016432; -.
DR PaxDb; 9940-ENSOARP00000016432; -.
DR Ensembl; ENSOART00000016667.1; ENSOARP00000016432.1; ENSOARG00000015317.1.
DR eggNOG; KOG1251; Eukaryota.
DR HOGENOM; CLU_021152_4_2_1; -.
DR OMA; LIHPFDH; -.
DR Proteomes; UP000002356; Chromosome 11.
DR Bgee; ENSOARG00000015317; Expressed in testis and 54 other cell types or tissues.
DR GO; GO:0003941; F:L-serine ammonia-lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR CDD; cd01562; Thr-dehyd; 1.
DR Gene3D; 3.40.50.1100; -; 2.
DR InterPro; IPR000634; Ser/Thr_deHydtase_PyrdxlP-BS.
DR InterPro; IPR001926; TrpB-like_PALP.
DR InterPro; IPR036052; TrpB-like_PALP_sf.
DR PANTHER; PTHR43050; SERINE / THREONINE RACEMASE FAMILY MEMBER; 1.
DR PANTHER; PTHR43050:SF1; SERINE RACEMASE; 1.
DR Pfam; PF00291; PALP; 1.
DR SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 1.
DR PROSITE; PS00165; DEHYDRATASE_SER_THR; 1.
PE 3: Inferred from homology;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 25..319
FT /note="Tryptophan synthase beta chain-like PALP"
FT /evidence="ECO:0000259|Pfam:PF00291"
SQ SEQUENCE 339 AA; 36544 MW; A7F7D2636162BE0E CRC64;
MTDKTMCDQY CISFADVEKA HVNIRDSIHL TPVLTSSILN QITGRNLFFK CELFQKTGSF
KIRGALNAIR GLISAHPKEK PRAVVTCSSG NHGQALSFAA RLEGIPAHVI VSETAPNCKK
LAIQAYGASI VYGEQSEEAR ENITKRIAEE TEGIMIHSNQ DPAVIAGQGT IAMEVLNQVP
LVDALVVPVG GGGMLAGIAI TVKALRPSVK VYAAEPLNAD DCYQSKLKGE LTPNPYPPET
IADGIKSSIG LNTWPIIRDL VDDVFTVTED EIKYATQLVW ERMKLLIEPT AGVGVAAVLS
QHFQTVPAEV KNICIVLSGG NVDLTSLTWV KKQDEKAAP
//
