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Database: UniProt
Entry: W5Q265_SHEEP
LinkDB: W5Q265_SHEEP
Original site: W5Q265_SHEEP 
ID   W5Q265_SHEEP            Unreviewed;      1103 AA.
AC   W5Q265;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-SEP-2017, entry version 26.
DE   SubName: Full=Potassium voltage-gated channel subfamily H member 8 {ECO:0000313|Ensembl:ENSOARP00000016803};
GN   Name=KCNH8 {ECO:0000313|Ensembl:ENSOARP00000016803};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000016803, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000016803, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000016803};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000016803}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOARP00000016803}.
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DR   EMBL; AMGL01012798; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01012799; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01012800; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01012801; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01012802; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01012803; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01012804; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01012805; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01012806; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01012807; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSOART00000017041; ENSOARP00000016803; ENSOARG00000015658.
DR   GeneTree; ENSGT00760000118772; -.
DR   OMA; NGSSFWC; -.
DR   OrthoDB; EOG091G0OXR; -.
DR   Proteomes; UP000002356; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR003950; K_chnl_volt-dep_ELK.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF13426; PAS_9; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   PRINTS; PR01465; ELKCHANNEL.
DR   SMART; SM00100; cNMP; 1.
DR   SMART; SM00086; PAC; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   TIGRFAMs; TIGR00229; sensory_box; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS50113; PAC; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Ion channel {ECO:0000256|SAAS:SAAS00091826};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00807593};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00807732};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00807568};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00807693}.
FT   TRANSMEM    211    236       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    256    275       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    314    332       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    353    376       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    418    436       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    448    472       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       90    144       PAC. {ECO:0000259|PROSITE:PS50113}.
FT   DOMAIN      550    667       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
FT   COILED      858    885       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1103 AA;  122554 MW;  8AF193079251B2D0 CRC64;
     MKGLLAPQNT FLDTIATRFD GTHSNFILAN AQVAKGFPIV YCSDGFCELA GFARTEVMQK
     SCSCKFLFGV ETNEQLMLQI EKSLEEKTEF KGEIMFYKKN VAGSPFWCLL DIVPIKNEKG
     DVVLFLASFK DITDTKVKIT PEDKKEDKAK GRSKAGAHFD SARRRSRAVL YHISGHLQRR
     EKNKLKISNN VFVDKPAFPE YKVSDAKKSK FILLHFSTFK AGWDWLILLA TFYVAVTVPY
     NVCFIGNDDL STTRSTTVSD IAVEILFIID IILNFRTTYV SKSGQVIFEA RSICIHYVTT
     WFIIDLIAAL PFDLLYAFNV TVVSLVHLLK TVRLLRLLRL LQKLDRYSQH STIVLTLLMS
     MFALLAHWMA CIWYVIGKME REDNSLLKWE VGWLHELGKR LESPYYGNNT LGGPSIRSAY
     IAALYFTLSS LTSVGFGNVS ANTDAEKIFS ICTMLIGALM HALVFGNVTA IIQRMYSRWS
     LYHTRTKDLK DFIRVHHLPQ QLKQRMLEYF QTTWSVNNGI DSNELLKDFP DELRSDITMH
     LNKEILQLSL FECASRGCLR SLSLHIKTSF CAPGEYLLRQ GDALQAIYFV CSGSMEVLKD
     STVLAILGKG DLIGANLSIK DQVIKTNADV KALTYCDLQC IILKGLFEVL DLYPEYAHKF
     VEDIQHDLTY NLREGHESDV ISRLSNKSTV SQSEPKGNGS IKKRLPSIVE DEEEEDDEGE
     ETASLSPVYT RAPASSRSKR PGGGKSYLGL SLKQLASGTV PFHSPIRVSS SNSPKTKQEM
     DAPNYGRRKE NLKLQLSTWN SAGPPDLSPR IVDGIEDGNS SEESQTFDFG SERIRPEPRI
     SPPLGDPEIG AAVLFIKAEE TRQQISKLNS EVTTLTQEVS QLGRDMKTVM QLLEHVLSPQ
     QQSRLCSLHT ASLRPSSFQG GMTWSTHQPC LHLQAAGAAY TPAQLCQGSV TPERWSVGPS
     SAGGSPLQTG AQEQSPAGVE LRASPSLDHA PAHCQVVQEG RLQLLRCISP QSDTTLTPLQ
     SISATLSSSA CSSSETSLHL VLPSRSEEGS LGQGAMSSFS LENLPGSWER ERRASISTDP
     LESFPLEMVS STAEGKDGRA GHV
//
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