ID W5Q3W3_SHEEP Unreviewed; 507 AA.
AC W5Q3W3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE SubName: Full=Lysophosphatidylcholine acyltransferase 1 {ECO:0000313|Ensembl:ENSOARP00000017402.1};
GN Name=LPCAT1 {ECO:0000313|Ensembl:ENSOARP00000017402.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000017402.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000017402.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000017402.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000017402.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- PATHWAY: Lipid metabolism; phospholipid metabolism.
CC {ECO:0000256|ARBA:ARBA00005074}.
CC -!- PATHWAY: Phospholipid metabolism. {ECO:0000256|ARBA:ARBA00025707}.
CC -!- SIMILARITY: Belongs to the 1-acyl-sn-glycerol-3-phosphate
CC acyltransferase family. {ECO:0000256|ARBA:ARBA00008655}.
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DR EMBL; AMGL01036818; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01036819; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01036820; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01036821; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5Q3W3; -.
DR SMR; W5Q3W3; -.
DR STRING; 9940.ENSOARP00000017402; -.
DR PaxDb; 9940-ENSOARP00000017402; -.
DR Ensembl; ENSOART00000017649.1; ENSOARP00000017402.1; ENSOARG00000016205.1.
DR eggNOG; KOG4666; Eukaryota.
DR HOGENOM; CLU_025017_0_1_1; -.
DR OMA; ADDYLYT; -.
DR UniPathway; UPA00085; -.
DR Proteomes; UP000002356; Chromosome 16.
DR Bgee; ENSOARG00000016205; Expressed in pituitary gland and 51 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0047184; F:1-acylglycerophosphocholine O-acyltransferase activity; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006644; P:phospholipid metabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd07991; LPLAT_LPCAT1-like; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR045252; LPCAT1-like.
DR InterPro; IPR002123; Plipid/glycerol_acylTrfase.
DR PANTHER; PTHR23063:SF57; LYSOPHOSPHATIDYLCHOLINE ACYLTRANSFERASE 1; 1.
DR PANTHER; PTHR23063; PHOSPHOLIPID ACYLTRANSFERASE; 1.
DR Pfam; PF01553; Acyltransferase; 1.
DR Pfam; PF13833; EF-hand_8; 1.
DR SMART; SM00563; PlsC; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF69593; Glycerol-3-phosphate (1)-acyltransferase; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 352..387
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 468..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 507 AA; 55821 MW; 012DEA4034771B1C CRC64;
PGVRSLGDSP RVTVPCPQVA VLTLTLFPVR LLAVVLMMLL AWPLALVSSL GPAGQEPEQP
PALWRRVVDV LLKAIMRTMW LAGGFHRVVV KGRQALPTEA AILTLAPHSS YFDAIPVTMT
MSSVVMKAES RDIPIWGTLI KYIRPVFVSR TDQDSRRKTV EEIKRRAQSG GRWAAIMIFP
EGTCTNRTCL ITFKPGAFIP GVPVQPVVLR YPNKLDTITW TWRGPGALKI LWLTLCQFHN
QVEIEFLPVY TPSEEEKKDP ALYASNVRQV MADLHSMAGT DSPFVACRAA RAEGPLRPPA
DTCLLEFARL LRGLGLKPER LEQDLDRHAE SARMTQGRRV TLPEFAAQLG VPESESLEDL
FSLFDEGGGG EVDLREYVVA LSVVCRPAGR PLGDARPSPQ MFGSQDGSVE EHALSSILKT
ALGVAELTVT HLFRAIDQEQ KGRIAFADCE RFAQATPDFA EEYLYPEQTR PRSCARTPPA
PTPNGFCADF SPESSATGMG PVRKKLD
//