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Database: UniProt
Entry: W5Q3W6_SHEEP
LinkDB: W5Q3W6_SHEEP
Original site: W5Q3W6_SHEEP 
ID   W5Q3W6_SHEEP            Unreviewed;      2148 AA.
AC   W5Q3W6;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-SEP-2017, entry version 27.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1D {ECO:0000313|Ensembl:ENSOARP00000017405};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000017405, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000017405, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000017405};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000017405}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOARP00000017405}.
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DR   EMBL; AMGL01045484; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01045485; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01045486; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01045487; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01045488; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01045489; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01045490; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01045491; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01045492; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01045493; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_011955293.1; XM_012099903.2.
DR   Ensembl; ENSOART00000017652; ENSOARP00000017405; ENSOARG00000016200.
DR   GeneID; 101106371; -.
DR   CTD; 776; -.
DR   GeneTree; ENSGT00830000128247; -.
DR   OMA; LIQVERP; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   Proteomes; UP000002356; Chromosome 19.
DR   ExpressionAtlas; W5Q3W6; baseline.
DR   GO; GO:1990454; C:L-type voltage-gated calcium channel complex; IEA:Ensembl.
DR   GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR   GO; GO:0051393; F:alpha-actinin binding; IEA:Ensembl.
DR   GO; GO:0030506; F:ankyrin binding; IEA:Ensembl.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0086059; F:voltage-gated calcium channel activity involved SA node cell action potential; IEA:Ensembl.
DR   GO; GO:0007188; P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0070509; P:calcium ion import; IEA:Ensembl.
DR   GO; GO:0086002; P:cardiac muscle cell action potential involved in contraction; IEA:Ensembl.
DR   GO; GO:0051928; P:positive regulation of calcium ion transport; IEA:Ensembl.
DR   GO; GO:0060372; P:regulation of atrial cardiac muscle cell membrane repolarization; IEA:Ensembl.
DR   GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
DR   GO; GO:1901016; P:regulation of potassium ion transmembrane transporter activity; IEA:Ensembl.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005452; LVDCC_a1dsu.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF239; PTHR10037:SF239; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   PRINTS; PR01636; LVDCCALPHA1D.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    130    147       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    167    187       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    199    218       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    271    294       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    350    371       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    383    405       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    523    541       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    561    584       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    653    672       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    725    752       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    887    905       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    925    945       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    957    983       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1003   1033       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1130   1155       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1209   1227       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1239   1259       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1334   1352       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1426   1449       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1583   1617       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      755    786       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2148 AA;  243576 MW;  D9215ADDB8F8177B CRC64;
     MMMMMMMKKM QHQRQQQADH ANEVNYARGT RLPLSGEGPT SQPNSSKQTV LSWQAAIDAA
     RQAKAAQTMS TSAPPPVGSL SQRKRQQYAK SKKQGNSSNS RPARALFCLS LNNPIRRACI
     SIVEWKPFDI FILLAIFANC VALAIYIPFP EDDSNSTNHN LEKVEYAFLI IFTVETFLKI
     IAYGLLLHPN AYVRNGWNLL DFVIVIVGLF SVILEQLTKE TEGGNHSSGK SGGFDVKALR
     AFRVLRPLRL VSGVPSLQVV LNSIIKAMVP LLHIALLVLF VIIIYAIIGL ELFIGKMHKT
     CFFADSDVVA EEDPAPCAFS GNGRQCTANG TECRSGWVGP NGGITNFDNF AFAMLTVFQC
     ITMEGWTDVL YWVNDAIGWE WPWVYFVSLI ILGSFFVLNL VLGVLSGEFS KEREKAKARG
     DFQKLREKQQ LEEDLKGYLD WITQAEDIDP ENEEEGGEES KRNTSMPTSE TESVNTENVS
     GEGENRGCCG SLCQAISKSK LSRRWRRWNR FSRRRCRAAV KSVTFYWLVI VLVFLNTLTI
     SSEHYNQPDW LTQIQDIANK VLLALFTCEM LVKMYSLGLQ AYFVSLFNRF DCFVVCGGIT
     ETILVELEIM SPLGISVFRC VRLLRIFKVT RHWTSLSNLV ASLLNSMKSI ASLLLLLFLF
     IIIFSLLGMQ LFGGKFNFDE TQTKRSTFDN FPQALLTVFQ ILTGEDWNAV MYDGIMAYGG
     PSSSGMIVCI YFIILFICGN YILLNVFLAI AVDNLADAES LNTAQKEEAE EKERKKIARK
     ESLENKKNNK PEVNQIANSD NKVTIDDYRE EDEDKDPYPP CDVPVGEEEE EEEEDEPEVP
     AGPRPRRISE LNMKEKIAPI PEGSAFFILS KTNPIRVGCH KLINHHIFTN LILVFIMLSS
     AALAAEDPIR SHSFRNTILG YFDYAFTAIF TVEILLKMMT FGAFLHKGAF CRNYFNLLDM
     LVVGVSLVSF GIQSSAISVV KILRVLRVLR PLRAINRAKG LKHVVQCVFV AIRTIGNIMI
     VTTLLQFMFA CIGVQLFKGK FYRCTDEAKS NPEECRGLFI LYKDGDVDSP VVRERIWQNS
     DFNFDNVLSA MMALFTVSTF EGWPALLYKA IDSNGENVGP VYNHRVEISI FFIIYIIIVA
     FFMMNIFVGF VIVTFQEQGE KEYKNCELDK NQRQCVEYAL KARPLRRYIP KNPYQYKFWY
     VVNSSPFEYM MFVLIMLNTL CLAMQHYEQS KMFNDAMDIL NMVFTGVFTV EMVLKVIAFK
     PKGYFSDAWN TFDSLIVIGS IVDVALSEAD NSEESNRISI TFFRLFRVMR LVKLLSRGEG
     IRTLLWTFIK SFQALPYVAL LIAMLFFIYA VIGMQMFGKV AMRDNNQINR NNNFQTFPQA
     VLLLFRCATG EAWQEIMLAC LPGKQCDPDS DYNPGEEYTC GSNFAIVYFI SFYMLCAFLI
     INLFVAVIMD NFDYLTRDWS ILGPHHLDEF KRIWSEYDPE AKGRIKHLDV VTLLRRIQPP
     LGFGKLCPHR VACKRLVAMN MPLNSDGTVM FNATLFALVR TALKIKTEGN LEQANEELRA
     VIKKIWKKTS MKLLDQVVPP AGDDEVTVGK FYATFLIQDY FRKFKKRKEQ GLVGKYPAKN
     STIALQAGLR TLHDIGPEIR RAISCDLQDD EPEETKREEE EDVFKRNGAL LGNHVNHVNS
     DRRDSLQQTN TTHRPLHVQR PSIPPASDTE KPLFPPAGNS VCHNHHNHNS IGKQVPSSTN
     ANLNNANMCK AAPGKRPSIG NLELVSENGH HSFHKHGREP HRRCSIKRTR YYETYIRSDS
     GDEQFPTICR EDPEIHGYFR DPRCPGEQEY FSSEEYYEDD SSPTGSRQSY GCGYYNRYPG
     SSLDFERPRG YHHPQSFSED DDSPVGYDSR RSPRRRLLPP TPTTPRRSSF NFECLRRQSS
     QEEVPPSPAF PPRTALPLHL MQQQIMAVAG LDSSKAQKYS PSHSTRSWAT PPATPSYRDW
     TPCYTPLIQV ERPEAPDQVN GSLPSLHRSS WYTDEPSVSY RTFTPASLTV PSSFHSKNSD
     KQRSADSLVE AVLISEGLGR YARDPKFVSA TKHEIADACD LTIDEMESAA SNLLNGNVHP
     RANGDVGPVS HRQDYELQDF GPGYSDEEPD PGRDEEDLAD EMICITTL
//
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