ID W5Q501_SHEEP Unreviewed; 1037 AA.
AC W5Q501;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Guanine nucleotide-binding protein G(S) subunit alpha {ECO:0008006|Google:ProtNLM};
GN Name=LOC101115640 {ECO:0000313|Ensembl:ENSOARP00000017791.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000017791.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000017791.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000017791.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000017791.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the G-alpha family. G(s) subfamily.
CC {ECO:0000256|ARBA:ARBA00007172}.
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DR EMBL; AMGL01025695; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01025696; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01025697; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01025698; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01025699; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01025700; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01025701; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5Q501; -.
DR SMR; W5Q501; -.
DR STRING; 9940.ENSOARP00000017791; -.
DR PaxDb; 9940-ENSOARP00000017791; -.
DR Ensembl; ENSOART00000018042.1; ENSOARP00000017791.1; ENSOARG00000016562.1.
DR eggNOG; KOG0099; Eukaryota.
DR HOGENOM; CLU_010619_0_0_1; -.
DR OMA; WIQCFNE; -.
DR Proteomes; UP000002356; Chromosome 13.
DR Bgee; ENSOARG00000016562; Expressed in pituitary gland and 54 other cell types or tissues.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR CDD; cd00066; G-alpha; 1.
DR Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000367; Gprotein_alpha_S.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10218:SF348; GUANINE NUCLEOTIDE-BINDING PROTEIN G(S) SUBUNIT ALPHA ISOFORMS XLAS; 1.
DR Pfam; PF00503; G-alpha; 1.
DR PRINTS; PR00318; GPROTEINA.
DR PRINTS; PR00443; GPROTEINAS.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
FT REGION 1..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 285..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 477..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 590..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 709..733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..356
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..423
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 596..627
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1037 AA; 111421 MW; 651E9EA668D4A9E3 CRC64;
MGVRNCLDGN NMSGQRNNPL EPGEQPEQPP LEAPGAAAPG AGPGPAEEME TPPPHSEPIP
IETEGEACGP PEVSRPNFQD LSQAIKEAGA QGGYSPPPEE AMPFEVEQAS LGSFWPTLQH
PGDTTGTGAG LEAFSPPVME PRASHEAVPS LGSYSPPPEE AMPFEFEQPD QGDNQPPLQV
SDLAPGGPGS VVFPEAPGAI RPANAGIRGG CSPPREEALP FEFDGAALGD DSPPPGLPRA
IPQIDGGGGS RITTVAVSSA ILLTPAANEP PLWVPGIIGS PSREAVRPSP HFAGDSPPME
VSRPPREIGS APVGVDDAPG DMDSPPVALD NLRIEVSGAP AEREQAEGER PPAEGEAAEM
EGGSATTAAE GGKVPDPGDR APAAAAEAAL AAPAAEAAPA APDPPAAGAA PAAPAAPASP
AAPAVPAAPA ASVAGAAPAA LVARGAPVGR AAPVPRAATV PRAATVPRAA SVPRATPITW
ANPTSGARPE ISFLRPPSPE IQAADPPVPQ PPRAFAWRGR SEPSCCYLYD DQISVSSDSG
DESDDGTFGC RGWFSSKRRK PRSNLLHNFL VRAFRGCVFG SESPQFRGSF SPKVKKAALA
EKRRQDRKEN AGKFGQKRSE KRHSQLTNKQ LQNKKMDNSH THRMLFLGNA ADFARVEGRF
QLDKPVPAIV RPRRRVVGWG TARKAGASGA GESGKSTIVK QMRILHVNGF NGEGGEEDPQ
AARSNSDGEK ATKVQDIKNN LKEAIETIVA AMSNLVPPVE LANPENQFRV DYILSVMNVP
DFDFPPEFYE HAKALWEDEG VRACYERSNE YQLIDCAQYF LDKIDVIKQD DYVPSDQDLL
RCRVLTSGIF ETKFQVDKVN FHMFDVGGQR DERRKWIQCF NEDVTAIIFV VASSSYNMVI
REDNQTNRLQ EALNLFKSIW NNRWLRTISV ILFLNKQDLL AEKVLAGKSK IEDYFPEFAR
YTTPEDATPE PGEDPRVTRA KYFIRDEFLR ISTASGDGRH YCYPHFTCAV DTENIRRVFN
DCRDIIQRMH LRQYELL
//
