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Database: UniProt
Entry: W5Q626_SHEEP
LinkDB: W5Q626_SHEEP
Original site: W5Q626_SHEEP 
ID   W5Q626_SHEEP            Unreviewed;       723 AA.
AC   W5Q626;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-SEP-2017, entry version 28.
DE   SubName: Full=Transient receptor potential cation channel subfamily V member 6 {ECO:0000313|Ensembl:ENSOARP00000018166};
GN   Name=TRPV6 {ECO:0000313|Ensembl:ENSOARP00000018166};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000018166, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000018166, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000018166};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000018166}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00788929}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOARP00000018166}.
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DR   EMBL; AMGL01089461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01089462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01089463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSOART00000018423; ENSOARP00000018166; ENSOARG00000016910.
DR   GeneTree; ENSGT00550000074425; -.
DR   OMA; VFEPMTS; -.
DR   OrthoDB; EOG091G0314; -.
DR   Proteomes; UP000002356; Chromosome 4.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR   CDD; cd00204; ANK; 2.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR004729; TRP_channel.
DR   InterPro; IPR024862; TRPV.
DR   InterPro; IPR008344; TRPV5/TRPV6.
DR   InterPro; IPR008345; TRPV6_channel.
DR   PANTHER; PTHR10582; PTHR10582; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   PRINTS; PR01765; ECACCHANNEL.
DR   PRINTS; PR01766; ECACCHANNEL1.
DR   SMART; SM00248; ANK; 5.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   TIGRFAMs; TIGR00870; trp; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023,
KW   ECO:0000256|SAAS:SAAS00844120};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Ion channel {ECO:0000256|SAAS:SAAS00816195};
KW   Ion transport {ECO:0000256|SAAS:SAAS00816776};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00816535}.
FT   TRANSMEM    330    354       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    392    414       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    426    447       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    453    471       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    492    513       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    525    543       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    555    581       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       47    264       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   REPEAT      118    150       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      164    196       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
SQ   SEQUENCE   723 AA;  82378 MW;  388525A50CEAFE4F CRC64;
     MGLPLPKEKG HILSLWRKLC RWFQRQEPWA QRRDEQNLLQ QKRICESPLL LAAKENNIQA
     LRKLLKYEAC DVHQKVPGAV GETALHVAAL YDNLEAAMVL MEAAPELVKE PMTSELYEGQ
     TALHIAVMNQ NVNLVKALLA HGASVSARAT GSAFRLSPHN LIYFGEHPLS FAACMGSEEI
     VRLLIEHGAD IRAQDSLGNT VLHILVLQPN KTFACQMYNL LLSYDRRGDH LQSLDLMLNH
     QGLTPFKLAG VEGNTVIFQN LVQKQKYIQW TCGPLTSTLY DLTEIDSSGE ELSLLELIVT
     SKKREARQIL DQTPVKELVT LKWKRYGRPY FCVLAATYLL YIVCFTVCCV YRPLKPRTDN
     ETDPRDSTLY QQKPRQEAYV TRQDHLRLVG ELVSICGAII ILFIEITDIF RVGVSRSFGQ
     TILGGPFHIL FITYSCMVLV TMVMRLTNTS GEVVPMSFAL VLGWCSVMYF ARGFQMLGPF
     TIMIQKMIFG DLMRFCWLMA VVILGFASAF FIIFQTEDPN ELGHFFNYPM ALFSTFELFL
     TIIDGPANYD VDLPFMYSIT YAAFAIIAAL LMLNLLIAMM GDTHWRVAHE RDELWRAQVV
     ATTVMLEKKL PRCLWPRSGI CGRKFGLGDR WFLRVEEKQD INQQRVRRYA QAFCHPGSED
     NRERLWLGSP FGARLSLPTP SVSRSTSGSS INWERLRQGT LKRELRGVVN KALEDEEGWE
     YQI
//
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