ID W5Q626_SHEEP Unreviewed; 723 AA.
AC W5Q626;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Ion transport domain-containing protein {ECO:0000259|Pfam:PF00520};
GN Name=TRPV6 {ECO:0000313|Ensembl:ENSOARP00000018166.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000018166.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000018166.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000018166.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000018166.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AMGL01089461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01089462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01089463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5Q626; -.
DR SMR; W5Q626; -.
DR STRING; 9940.ENSOARP00000018166; -.
DR PaxDb; 9940-ENSOARP00000018166; -.
DR Ensembl; ENSOART00000018423.1; ENSOARP00000018166.1; ENSOARG00000016910.1.
DR eggNOG; KOG3676; Eukaryota.
DR HOGENOM; CLU_012795_2_0_1; -.
DR OMA; LCLWNKF; -.
DR Proteomes; UP000002356; Chromosome 4.
DR Bgee; ENSOARG00000016910; Expressed in mammary gland and 42 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR CDD; cd22192; TRPV5-6; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR024862; TRPV.
DR InterPro; IPR008344; TRPV5/TRPV6.
DR InterPro; IPR008345; TrpV6.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10582:SF25; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 6; 1.
DR PANTHER; PTHR10582; TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR01415; ANKYRIN.
DR PRINTS; PR01765; ECACCHANNEL.
DR PRINTS; PR01766; ECACCHANNEL1.
DR SMART; SM00248; ANK; 5.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 330..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 392..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 426..447
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 453..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 492..513
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 525..543
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 555..581
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 118..150
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 164..196
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 396..589
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
SQ SEQUENCE 723 AA; 82378 MW; 388525A50CEAFE4F CRC64;
MGLPLPKEKG HILSLWRKLC RWFQRQEPWA QRRDEQNLLQ QKRICESPLL LAAKENNIQA
LRKLLKYEAC DVHQKVPGAV GETALHVAAL YDNLEAAMVL MEAAPELVKE PMTSELYEGQ
TALHIAVMNQ NVNLVKALLA HGASVSARAT GSAFRLSPHN LIYFGEHPLS FAACMGSEEI
VRLLIEHGAD IRAQDSLGNT VLHILVLQPN KTFACQMYNL LLSYDRRGDH LQSLDLMLNH
QGLTPFKLAG VEGNTVIFQN LVQKQKYIQW TCGPLTSTLY DLTEIDSSGE ELSLLELIVT
SKKREARQIL DQTPVKELVT LKWKRYGRPY FCVLAATYLL YIVCFTVCCV YRPLKPRTDN
ETDPRDSTLY QQKPRQEAYV TRQDHLRLVG ELVSICGAII ILFIEITDIF RVGVSRSFGQ
TILGGPFHIL FITYSCMVLV TMVMRLTNTS GEVVPMSFAL VLGWCSVMYF ARGFQMLGPF
TIMIQKMIFG DLMRFCWLMA VVILGFASAF FIIFQTEDPN ELGHFFNYPM ALFSTFELFL
TIIDGPANYD VDLPFMYSIT YAAFAIIAAL LMLNLLIAMM GDTHWRVAHE RDELWRAQVV
ATTVMLEKKL PRCLWPRSGI CGRKFGLGDR WFLRVEEKQD INQQRVRRYA QAFCHPGSED
NRERLWLGSP FGARLSLPTP SVSRSTSGSS INWERLRQGT LKRELRGVVN KALEDEEGWE
YQI
//
