ID W5Q6D3_SHEEP Unreviewed; 561 AA.
AC W5Q6D3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=IF rod domain-containing protein {ECO:0000259|PROSITE:PS51842};
GN Name=LOC101111178 {ECO:0000313|Ensembl:ENSOARP00000018273.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000018273.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000018273.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000018273.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000018273.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMGL01080309; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5Q6D3; -.
DR SMR; W5Q6D3; -.
DR STRING; 9940.ENSOARP00000018273; -.
DR PaxDb; 9940-ENSOARP00000018273; -.
DR Ensembl; ENSOART00000018534.1; ENSOARP00000018273.1; ENSOARG00000017016.1.
DR eggNOG; ENOG502QURK; Eukaryota.
DR HOGENOM; CLU_012560_6_1_1; -.
DR OMA; FASFREC; -.
DR Proteomes; UP000002356; Chromosome 3.
DR Bgee; ENSOARG00000017016; Expressed in rumen and 21 other cell types or tissues.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF39; KERATIN, TYPE II CYTOSKELETAL 6A; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 3.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 164..477
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 219..295
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 375..455
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 561 AA; 60089 MW; EEB809459AC6E98C CRC64;
TMSCKSTVKT KTISCRGFSA GSARVPGVCR SGFSSVSLSR SRGSGGLAGV CGGAGFGSRS
LYGLGGSKRI SIAGGSCVIG GGYGGRIGVG YGFGGGAGSG IGFGAGAGSG FGLGGGAGFG
GGYGGYGFSV FPTGGIQEVT VNQSLLTPLN LQIDPTIQRV RTEEREQIKT LNNKFASFRE
CVRFLEQQNK VLDTKWTLLQ EQGTRTVRQN LEPLFEQYIN NLRRQLDSIL GERGRLDSEL
RGMQDTVEDF KNKYEDEINK RTAAENEFVK LKKDVDSAYM NKVELQAKVD ALTDEINFLR
TFYDAELAQM QSYISDTSVV LSMDNNRNLD LDSIIAEVKA QYEEIAQRSR AEAESWYQSK
YEELRVTAGR HGDDLRNTKQ EISEINRVIQ RLRSEIDHVK KQCTSLQSAI ADAEQRGELA
LKDARNKLAD LEDALQKAKQ DMARLLKEYQ ELMNVKLALD VEIATYRKLL EGEECRLSGE
GAGQVNISVV QSTVSSGYGG ASGLGSGLGI GGGSGCSYSI GGGFSSGSGR AIGGGYGSSG
GSCSTIKYTT TSSSSRKSYK H
//
