ID W5Q6E3_SHEEP Unreviewed; 1184 AA.
AC W5Q6E3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=WD repeat-containing protein 35 {ECO:0000256|PIRNR:PIRNR037536};
GN Name=WDR35 {ECO:0000313|Ensembl:ENSOARP00000018283.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000018283.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000018283.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000018283.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000018283.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: As a component of the IFT complex A (IFT-A), a complex
CC required for retrograde ciliary transport and entry into cilia of G
CC protein-coupled receptors (GPCRs), it is involved in ciliogenesis and
CC ciliary protein trafficking. {ECO:0000256|PIRNR:PIRNR037536}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|PIRNR:PIRNR037536}. Cytoplasm,
CC cytoskeleton, cilium basal body {ECO:0000256|PIRNR:PIRNR037536}.
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DR EMBL; AMGL01075629; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5Q6E3; -.
DR STRING; 9940.ENSOARP00000018283; -.
DR PaxDb; 9940-ENSOARP00000018283; -.
DR Ensembl; ENSOART00000018544.1; ENSOARP00000018283.1; ENSOARG00000017021.1.
DR eggNOG; KOG2041; Eukaryota.
DR HOGENOM; CLU_004048_1_0_1; -.
DR OMA; HCASPME; -.
DR Proteomes; UP000002356; Chromosome 3.
DR Bgee; ENSOARG00000017021; Expressed in pituitary gland and 52 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0036064; C:ciliary basal body; IEA:UniProtKB-UniRule.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030991; C:intraciliary transport particle A; IEA:UniProtKB-UniRule.
DR GO; GO:0060271; P:cilium assembly; IEA:InterPro.
DR GO; GO:0035721; P:intraciliary retrograde transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.40.470; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039857; Ift122/121.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR017233; WDR35.
DR PANTHER; PTHR12764:SF5; LD29485P; 1.
DR PANTHER; PTHR12764; WD REPEAT DOMAIN-RELATED; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF00400; WD40; 1.
DR PIRSF; PIRSF037536; WD_repeat_p35; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|PIRNR:PIRNR037536};
KW Cilium {ECO:0000256|PIRNR:PIRNR037536};
KW Cilium biogenesis/degradation {ECO:0000256|PIRNR:PIRNR037536};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR037536};
KW Cytoskeleton {ECO:0000256|PIRNR:PIRNR037536};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 67..98
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 130..188
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
SQ SEQUENCE 1184 AA; 134102 MW; C631023C42FC7EE8 CRC64;
MFFYLSKKVA MPNNVKLKCV SWNKDQGFIA CGGDDGLLKV LKLETQTDDT KLRGLAAPSN
LSMNQALEGH SGSVQIVTWN EQYQKLTTSD QNGLIIVWML YKGSWYEEMI NNRNKSVVRS
MSWNADGQKI CIVYEDGAVI VGSVDGNRIW GKDLKGVQLC HVAWSADSKA LLFGMANGEI
HIYDNQGNFM VKMKLNCLVN VTGAVSIAGI HWYHGTEGYV EPDCPCLAIC FDNGRCQIMR
HENDQRLDPV LIDTGMYVVS IQWNHAGSVL AVAGSQKAIT QDKDVNTVQF YTPFGEHLGT
LKVPGKHMSA LSWEGGGLKI ALTVDSFIYF ANIRPDYKWG YCSNTVVYAY TRRDRPEYCV
TFWDTKNNDK YVKYVKSLIS ITTCGDFCIL ATKADENHPQ EENEMETFGA MFVLVLCNSI
GTPLDPKYID LVPLFVTMTK THVIAASKEA FYIWQYRVAK KLTALEINQI TRSRKEGRER
IYHVDDTPSG SLDGVLDYSK AIQGTRDPIC AITASDKTLI VSRESGTFQR YSLPNVGLIQ
KYFLDCQAYQ LSLNCNSSRL AIIDILGVLT FFDLDARVTD STGQQVVGEL LKLERKDVWD
MKWAKDNPDL FAVMEKTRMY VFRNLDPEEP IQTSGYICNF EDLEIKSVLL DEILKNPEYP
NKDYIINFEI RSLRDSRALI EKVGIEDASQ FIEDNPHPRL WRLLAEAALQ KLDLHTAEQA
FVRCKDYQGI KFVKRLGNLQ SEPMKQAEVA AYFGRFEEAE RMYLDMDRSR DLAIGLRLKL
GDWFRVLQLL KTGSGDADDS LLEQAHNAIG DYFADRQKRL NAIQYYVQGR NQERLAECYY
MLEDYVGLEN LASSLPENHK LLPEIAQMFV RVGMCEQAVT AFLKCNQPKA AVDTCVHLNQ
WNKAVELAKS HNMKEIGSLL ARYASHLLEK NKTLDAIELY RKANYFYDAA KLMFKIADEE
AKKRTKPLRV KKLYVLAALL IEQYHEQMKN AQRGKVKGKS SEATSALAGL LEEEVLSTSS
RFTDNAWRGA EAYHFFILAQ RQLYEGYVDT ALKTALHLRD YEDIIPAVEI YSLLALCACA
SRAFGTCSKA FIKLESLETL SSEQKQQYED LALEIFTKHT PKDNRKSELD GLLEGGEGKL
PTCVATGSPI AEYQFWMCSV CKHCVLAQEI NNYNFCPLCH SAVG
//
