GenomeNet

Database: UniProt
Entry: W5Q6H9_SHEEP
LinkDB: W5Q6H9_SHEEP
Original site: W5Q6H9_SHEEP 
ID   W5Q6H9_SHEEP            Unreviewed;       470 AA.
AC   W5Q6H9;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   25-OCT-2017, entry version 25.
DE   RecName: Full=Triacylglycerol lipase {ECO:0000256|RuleBase:RU362046};
DE            EC=3.1.1.3 {ECO:0000256|RuleBase:RU362046};
DE   AltName: Full=Pancreatic lipase {ECO:0000256|RuleBase:RU362046};
GN   Name=PNLIPRP2 {ECO:0000313|Ensembl:ENSOARP00000018319};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000018319, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000018319, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000018319};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000018319}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY: Triacylglycerol + H(2)O = diacylglycerol + a
CC       carboxylate. {ECO:0000256|RuleBase:RU362046}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU362046,
CC       ECO:0000256|SAAS:SAAS00553472}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase
CC       family. {ECO:0000256|RuleBase:RU362046,
CC       ECO:0000256|SAAS:SAAS00591292}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOARP00000018319}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AMGL01064261; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSOART00000018580; ENSOARP00000018319; ENSOARG00000017067.
DR   GeneTree; ENSGT00760000119069; -.
DR   OMA; PWDPKDI; -.
DR   OrthoDB; EOG091G0DJ5; -.
DR   Proteomes; UP000002356; Chromosome 22.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004806; F:triglyceride lipase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006968; P:cellular defense response; IEA:Ensembl.
DR   GO; GO:0007586; P:digestion; IEA:Ensembl.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   CDD; cd00707; Pancreat_lipase_like; 1.
DR   Gene3D; 2.60.60.20; -; 1.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR013818; Lipase/vitellogenin.
DR   InterPro; IPR016272; Lipase_LIPH.
DR   InterPro; IPR033906; Lipase_N.
DR   InterPro; IPR002331; Lipase_panc.
DR   InterPro; IPR001024; PLAT/LH2_dom.
DR   InterPro; IPR036392; PLAT/LH2_dom_sf.
DR   InterPro; IPR000734; TAG_lipase.
DR   PANTHER; PTHR11610; PTHR11610; 1.
DR   Pfam; PF00151; Lipase; 1.
DR   Pfam; PF01477; PLAT; 1.
DR   PIRSF; PIRSF000865; Lipoprotein_lipase_LIPH; 1.
DR   PRINTS; PR00823; PANCLIPASE.
DR   PRINTS; PR00821; TAGLIPASE.
DR   SMART; SM00308; LH2; 1.
DR   SUPFAM; SSF49723; SSF49723; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
DR   PROSITE; PS50095; PLAT; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR000865-3,
KW   ECO:0000256|RuleBase:RU362046, ECO:0000256|SAAS:SAAS00709807};
KW   Lipid degradation {ECO:0000256|RuleBase:RU362046};
KW   Lipid metabolism {ECO:0000256|RuleBase:RU362046};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Secreted {ECO:0000256|RuleBase:RU362046,
KW   ECO:0000256|SAAS:SAAS00439306};
KW   Signal {ECO:0000256|RuleBase:RU362046}.
FT   SIGNAL        1     18       {ECO:0000256|RuleBase:RU362046}.
FT   CHAIN        19    470       Triacylglycerol lipase.
FT                                {ECO:0000256|RuleBase:RU362046}.
FT                                /FTId=PRO_5009737981.
FT   DOMAIN      358    470       PLAT. {ECO:0000259|PROSITE:PS50095}.
FT   ACT_SITE    172    172       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR000865-1}.
FT   ACT_SITE    196    196       Charge relay system. {ECO:0000256|PIRSR:
FT                                PIRSR000865-1}.
FT   ACT_SITE    283    283       Charge relay system. {ECO:0000256|PIRSR:
FT                                PIRSR000865-1}.
FT   DISULFID     22     28       {ECO:0000256|PIRSR:PIRSR000865-3}.
FT   DISULFID    110    121       {ECO:0000256|PIRSR:PIRSR000865-3}.
FT   DISULFID    257    281       {ECO:0000256|PIRSR:PIRSR000865-3}.
FT   DISULFID    305    316       {ECO:0000256|PIRSR:PIRSR000865-3}.
FT   DISULFID    319    324       {ECO:0000256|PIRSR:PIRSR000865-3}.
FT   DISULFID    454    470       {ECO:0000256|PIRSR:PIRSR000865-3}.
SQ   SEQUENCE   470 AA;  52240 MW;  1C143113E9D6E2AC CRC64;
     KMLPSWTIGL LLLATVRGKE ICYEPFGCFS DEKPWTGTLQ RPLKLFPWSP EDIDAHFLLY
     TNENPNNYQR INITDLATVK ASNFQLDRKT RFVIHGFIDD GDSGWPTDMC KKMFKVEKVN
     CICVDWEHGA WTEYTQAVHN TRVVGAEIAF FVQGLSTELG YGPENVHLIG HSLGAQLAAE
     AGRRLGGQVG RITGLDPAQP CFEGTPEEVR LDPSDAMFVD VIHTDSASII PFLSLGIRQK
     VGHLDFYPNG GKEMPGCQKN ILSTIIDING IWQGVQDFVA CSHLRSYKYY SSSILNPDGF
     LGYPCASYEQ FQEGGCFPCP AGGCPKMGHY ADQFQGKTSA VGQTFFLNTG SSGNFTSWRY
     RVSVTLAGTK KVRGSIRIAL YGSNGNSKQY QIFKGSLQPD ASHMHDIDVD LNIGKVQKVK
     FLWNNNVINL FRPKLGASRI TVQGGEDRTE YNFCSNNTVQ EDALQTLYPC
//
DBGET integrated database retrieval system