ID W5Q6I0_SHEEP Unreviewed; 915 AA.
AC W5Q6I0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Trafficking kinesin-binding protein 2 {ECO:0008006|Google:ProtNLM};
GN Name=TRAK2 {ECO:0000313|Ensembl:ENSOARP00000018320.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000018320.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000018320.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000018320.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000018320.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the milton family.
CC {ECO:0000256|ARBA:ARBA00007007}.
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DR EMBL; AMGL01055353; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01055354; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01055355; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01055356; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01055357; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5Q6I0; -.
DR SMR; W5Q6I0; -.
DR STRING; 9940.ENSOARP00000018320; -.
DR PaxDb; 9940-ENSOARP00000018320; -.
DR Ensembl; ENSOART00000018581.1; ENSOARP00000018320.1; ENSOARG00000017068.1.
DR eggNOG; KOG4360; Eukaryota.
DR HOGENOM; CLU_013450_0_1_1; -.
DR OMA; LDGSHKF; -.
DR Proteomes; UP000002356; Chromosome 2.
DR Bgee; ENSOARG00000017068; Expressed in metanephros cortex and 54 other cell types or tissues.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR InterPro; IPR006933; HAP1_N.
DR InterPro; IPR022154; TRAK1/2_C.
DR PANTHER; PTHR15751; TRAFFICKING KINESIN-BINDING PROTEIN; 1.
DR PANTHER; PTHR15751:SF13; TRAFFICKING KINESIN-BINDING PROTEIN 2; 1.
DR Pfam; PF04849; HAP1_N; 1.
DR Pfam; PF12448; Milton; 1.
DR SMART; SM01424; HAP1_N; 1.
DR SMART; SM01423; Milton; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 48..353
FT /note="HAP1 N-terminal"
FT /evidence="ECO:0000259|SMART:SM01424"
FT DOMAIN 415..567
FT /note="Trafficking kinesin-binding protein C-terminal"
FT /evidence="ECO:0000259|SMART:SM01423"
FT REGION 440..478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 763..794
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 133..167
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 203..332
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 447..478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 772..793
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 915 AA; 102124 MW; 9A6C124174C20CE0 CRC64;
MSQSQDATFT ALMGEENLMN INHRDSESIT DVCSNEDVPE VELVSLLEEQ LPQYKLRVDS
LFLYENQDWT QSPHQQQHAS DTLSPVLAEE TFRYMILGTD RVEQMTKTYN DIDMVTHLLA
ERDRDLELAA RIGQALLKRN HALSEQNETL EEQLGQAFDQ VNQLQHELSK KDELLRIVSI
ASEESETDSS CSTPLRFNES FSLSQGLLQL DMLQEKLKEL EEENMLLRSK ACHIKTETIT
YEEKEQQLVS DCVKELRETN AQMSRMTEEL SGKSDELIRY QEEISSLLSQ IVDLQHKLKE
HVIEKEELRL HLQASKDAQR QLTMELHELQ DRNMECLGML HESQEEIKEL RSRSSPAAHL
YFSQPYGVFS GESLAAEIEG TMRKKLSLDE ESSLFKQKAQ QKRVFDTVKV ANDTRGRSVP
FPILPIPGSN RSSVIMTAKP FESGLEPTEG KTTQKSNLEE DPGNIQKADQ PGPSTESDLA
TALHRLSLRR QNYLSEKQFF AEEWQRKIQV LADQKEEGSG CGTPTESLAS LYTDQSEITD
LSSASCLRGF MPEKLQIVKP LEAYSGSQTL HQWQQLAQPN LGTILDPRPG VITKGFTQLP
KDAIYHLSDL EEDEEEGITF QVQQPLQVEQ KTSISQPVTG IFLPPMTSAG GPVTVATSNP
GKCLSCTNST FTFTTCRILH PSDITQVTPS SGFPSLSCAS SGSSSSNTEV NSPAVSYRLS
IGESITNRRD STITFSSTMS LAKLLQERGI SAKVYHSPIS ENPLLQPLPR GLSTPSTPPN
SPSHSPCPSP LPVEPQVHLS ENFLASRPAE TFLQEMYGLR PSRNPPDVGQ LKMNLVDRLK
RLGIARVIKT PQAQANGRSQ KAENGLQRPN SAVYLNSGSN LLSGLRRNQS LPVMLGSFST
PVCTSSPKMD ILKED
//
