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Database: UniProt
Entry: W5Q748_SHEEP
LinkDB: W5Q748_SHEEP
Original site: W5Q748_SHEEP 
ID   W5Q748_SHEEP            Unreviewed;      1990 AA.
AC   W5Q748;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   07-JUN-2017, entry version 27.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN8A {ECO:0000313|Ensembl:ENSOARP00000018540};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000018540, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000018540, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000018540};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000018540}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOARP00000018540}.
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DR   EMBL; AMGL01080340; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01080341; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01080342; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01080343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01080344; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSOART00000018802; ENSOARP00000018540; ENSOARG00000017269.
DR   GeneTree; ENSGT00830000128242; -.
DR   OMA; YMIDEDH; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000002356; Chromosome 3.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR008054; Na_channel_a8su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF00612; IQ; 1.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01667; NACHANNEL8.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    128    151       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    199    219       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    254    274       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    387    414       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    764    782       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    794    812       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    874    902       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    961    987       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1209   1227       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1248   1267       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1279   1302       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1323   1351       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1448   1474       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1533   1551       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1563   1581       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1593   1613       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1650   1678       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1753   1776       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      131    421       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      499    711       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      764    991       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1001   1202       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1207   1482       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1532   1786       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      411    449       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1990 AA;  226305 MW;  29A5C650677FC037 CRC64;
     MAARLLAPPG PDSFKPFTPE SLANIERRIA ESKLKKPPKA DGSHREDDED SKPKPNSDLE
     AGKSLPFIYG DIPQGLVAVP LEDFDPYYLT QKTFVVLNRG KTLFRFSATP ALYILSPFNL
     IRRIAIKILI HSLFSMIIMC TILTNCVFMT FSNPPDWSKN VEYTFTGIYT FESLVKIIAR
     GFCIDGFTFL RDPWNWLDFS VIMMAYVTEF VDLGNVSALR TFRVLRALKT ISVIPGLKTI
     VGALIQSVKK LSDVMILTVF CLSVFALIGL QLFMGNLRNK CVVWPINFNE SYLENGTKGF
     DWEEYINNKT NFYIVPGMLE PLLCGNSSDA GQCPEGYQCM KAGRNPNYGY TSFDTFSWAF
     LALFRLMTQD YWENLYQLTL RAAGKTYMIF FVLVIFVGSF YLVNLILAVV AMAYEEQNQA
     TLEEAEQKEA EFKAMLEQLK KQQEEAQAAA MATSAGTVSE DAIEEEGEEG AGSPRSSSEI
     SKLSSKSAKE RRNRRKKRKQ KELSEGEEKG DPEKVFKSES EDGLRRKGFR LPDNRIGRKF
     SIMNQSLLGI PVPPSPPRHN SKSSIFSFRG PGRFRDPGSE NEFADDEHST VEESEGRRDS
     LFIPIRARER RSSYGKNQGS RSSRIFPSLR RSVKRNSTVD CNGVVSLIGG PGSHISGRLL
     PEVKIDKAAT DDSHIGATTE VEIKKKGPGS LLVSMDQLAS YGRKDRINSI LSVVTNTLVE
     ELEESQRKCP PCWYKFANTF LIWECHPYWI KLKEIVNLIV MDPFVDLAIT ICIVLNTLFM
     AMEHHPMTPQ FEHVLAVGNL VFTGIFTAEM FLKLIAMDPY YYFQEGWNIF DGFIVSLSLM
     ELSLADVEGL SVLRSFRLLR VFKLAKSWPT LNMLIKIIGN SVGALGNLTL VLAIIVFIFA
     VVGMQLFGKS YKECVCKINQ DCELPRWHMH DFFHSFLIVF RVLCGEWIET MWDCMEVAGQ
     AMCLIVFMMV MVIGNLVVLN LFLALLLSSF SADNLAATDD DGEMNNLQIS VIRIKKGVAW
     IKLKVHAFMQ AHFKQREADE VKPLDELYEK KANCIANHTG ADIHRNGDFQ KNGNGTTSGI
     GSSVEKYIID EDHMSFINNP NLTVRVPIAV GESDFENLNT EDVSSESDPE GSKDKLDDTS
     SSEGSTIDIK PEVEEVPVEQ PEEYLDPDAC FTEGCVQRFK CCQVNTEEGL GKSWWILRKT
     CFLIVEHNWF ETFIIFMILL SSGALAFEDI YIEQRKTIRT ILEYADKVFT YIFILEMLLK
     WTAYGFVKFF TNAWCWLDFL IVAVSLVSLI ANALGYSELG AIKSLRTLRA LRPLRALSRF
     EGMRVVVNAL VGAIPSIMNV LLVCLIFWLI FSIMGVNLFA GKYHYCFNES SEIRFEIEDV
     NNKTECEKLM EGNNTEIRWK NVKINFDNVG AGYLALLQVA TFKGWMDIMY AAVDSRKPDE
     QPKYEDNIYM YIYFVIFIIF GSFFTLNLFI GVIIDNFNQQ KKKFGGQDIF MTEEQKKYYN
     AMKKLGSKKP QKPIPRPLNK IQGIVFDFVT QQAFDIVIMM LICLNMVTMM VETDTQSKQM
     ENILYWINLV FVIFFTCECV LKMFALRHYY FTIGWNIFDF VVVILSIVGM FLADIIEKYF
     VSPTLFRVIR LARIGRILRL IKGAKGIRTL LFALMMSLPA LFNIGLLLFL VMFIFSIFGM
     SNFAYVKHEA GIDDMFNFET FGNSMICLFQ ITTSAGWDGL LLPILNRPPD CNLDKEHPGS
     GFKGDCGNPS VGIFFFVSYI IISFLIVVNM YIAIILENFS VATEESADPL SEDDFETFYE
     IWEKFDPDAT QFIEYCKLAD FADALEHPLR VPKPNTIELI AMDLPMVSGD RIHCLDILFA
     FTKRVLGDSG ELDILRQQME ERFVASNPSK VSYEPITTTL RRKQEEVSAV VLQRAYRGHL
     ARRGFICKKT TSNKLENGGT HREKKESTPS TASLPSYDSV TKPEKEKQQR AEEGRRERAK
     RQKEVRESKC
//
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