ID W5Q8J8_SHEEP Unreviewed; 854 AA.
AC W5Q8J8; A0A6P3TD07;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Vacuolar protein sorting-associated protein 41 homolog {ECO:0000256|ARBA:ARBA00029538, ECO:0000256|PIRNR:PIRNR028921};
GN Name=VPS41 {ECO:0000313|Ensembl:ENSOARP00000019040.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000019040.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000019040.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000019040.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000019040.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in vesicle-mediated protein trafficking to
CC lysosomal compartments including the endocytic membrane transport
CC pathways. {ECO:0000256|PIRNR:PIRNR028921}.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|PIRNR:PIRNR028921}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR028921}. Late endosome membrane
CC {ECO:0000256|PIRNR:PIRNR028921}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR028921}. Early endosome membrane
CC {ECO:0000256|PIRNR:PIRNR028921}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR028921}. Lysosome membrane
CC {ECO:0000256|PIRNR:PIRNR028921}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR028921}. Golgi apparatus, trans-Golgi network
CC {ECO:0000256|PIRNR:PIRNR028921}. Cytoplasmic vesicle, clathrin-coated
CC vesicle {ECO:0000256|PIRNR:PIRNR028921}. Vesicle
CC {ECO:0000256|ARBA:ARBA00004373}.
CC -!- SIMILARITY: Belongs to the VPS41 family.
CC {ECO:0000256|ARBA:ARBA00009582, ECO:0000256|PIRNR:PIRNR028921}.
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DR EMBL; AMGL01088476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01088477; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01088478; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01088479; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01088480; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01088481; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01088482; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01088483; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012032398.1; XM_012177008.2.
DR AlphaFoldDB; W5Q8J8; -.
DR STRING; 9940.ENSOARP00000019040; -.
DR PaxDb; 9940-ENSOARP00000019040; -.
DR Ensembl; ENSOART00000019308.1; ENSOARP00000019040.1; ENSOARG00000017742.1.
DR GeneID; 101120659; -.
DR KEGG; oas:101120659; -.
DR CTD; 27072; -.
DR eggNOG; KOG2066; Eukaryota.
DR HOGENOM; CLU_001285_2_2_1; -.
DR OMA; PQLVWQD; -.
DR OrthoDB; 8838at2759; -.
DR Proteomes; UP000002356; Chromosome 4.
DR Bgee; ENSOARG00000017742; Expressed in hippocampal formation and 52 other cell types or tissues.
DR GO; GO:0030123; C:AP-3 adaptor complex; IEA:Ensembl.
DR GO; GO:0071439; C:clathrin complex; IEA:Ensembl.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:1902501; C:lysosomal HOPS complex; IEA:Ensembl.
DR GO; GO:0015630; C:microtubule cytoskeleton; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IEA:Ensembl.
DR GO; GO:0034058; P:endosomal vesicle fusion; IEA:UniProtKB-UniRule.
DR GO; GO:0008333; P:endosome to lysosome transport; IEA:Ensembl.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:1902774; P:late endosome to lysosome transport; IEA:Ensembl.
DR GO; GO:0006623; P:protein targeting to vacuole; IEA:InterPro.
DR CDD; cd16690; RING-H2_Vps41; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR016902; VPS41.
DR InterPro; IPR045111; Vps41/Vps8.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001841; Znf_RING.
DR PANTHER; PTHR12616; VACUOLAR PROTEIN SORTING VPS41; 1.
DR PANTHER; PTHR12616:SF1; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG; 1.
DR Pfam; PF00637; Clathrin; 1.
DR PIRSF; PIRSF028921; VPS41; 1.
DR SMART; SM00299; CLH; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50236; CHCR; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|PIRNR:PIRNR028921};
KW Endosome {ECO:0000256|PIRNR:PIRNR028921};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW ECO:0000256|PIRNR:PIRNR028921}; Lysosome {ECO:0000256|PIRNR:PIRNR028921};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Protein transport {ECO:0000256|PIRNR:PIRNR028921};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Transport {ECO:0000256|PIRNR:PIRNR028921};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
SQ SEQUENCE 854 AA; 98557 MW; AFFCB64B06A0222C CRC64;
MAEAEEQETG SLEESTDESE EEESEEEPKL KYERLSNGVT EILQKDAASC MTVHDKFLAL
GTHYGKVYLL DVQGNITQKF DVSPVKINQV SLDESGEHMG VCAEDGKVQV FGLYSGEEFH
ETFDCPIKII AVHPHFVRSS CKQFVTGGKK LLLFERSWMS RWKSSVLHEG EGNIRSVKWR
GHLIAWANNM GVKIFDITSK QRITNVPRDD ISLRPDMYPC SLCWKDNVTL IIGWGTSVKI
CSVKERHASE MRDLPSRYVE IVSQFETEFY ISGLAPLCDQ LVVLSYVKEV SEKTEREYCA
RPRLDIIQPL SETCEEISSD ALTVRGFQEN ECRDYHLEYS EGESLFYIVS PRDVVVAKER
DQDDHIDWLL EKKKYEEALM AAEISQKNIK RHKILDIGLA YINHLVARGE YDIAARKCQK
ILGKNAALWE YEVYKFKEIG QLKAISPYLP RGDPVLKPLI YEMILHEFLE SDYEGFATLI
REWPGDLYNN SVIVQAVRDH LKKDSQNRTL LKTLAELYTY DKNYGNALEI YLTLRHKDVF
QLIHKHNLFS SIKDKIVLLM DFDSEKAVDM LLDNEDKISI KKVVEELEDR PELQHVYLHK
LFKRDHHKGQ RYHEKQISLY AEFDRPNLLP FLRDSIHCPL EKALEICQQR NFVEETVYLL
SRMGNSRSAL KMIMEELHDV DKAIEFAKEQ DDAELWEDLI LYSIDKPPFI TGLLNNIGTH
VDPILLIHRI KEGMEIPNLR DSLVKILQDY NLQILLREGC KKILVADSLS LLKKMHRTQM
KGILVDEENI CESCLSPILP SDAAKPFSMV VFHCRHMFHK ECLPVPSMTS PAQFCNICSA
KHRGPGSAIL EMKK
//
