GenomeNet

Database: UniProt
Entry: W5Q8S4_SHEEP
LinkDB: W5Q8S4_SHEEP
Original site: W5Q8S4_SHEEP 
ID   W5Q8S4_SHEEP            Unreviewed;       887 AA.
AC   W5Q8S4;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   28-MAR-2018, entry version 24.
DE   SubName: Full=N-deacetylase and N-sulfotransferase 3 {ECO:0000313|Ensembl:ENSOARP00000019116};
GN   Name=NDST3 {ECO:0000313|Ensembl:ENSOARP00000019116};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000019116, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000019116, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000019116};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000019116}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
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DR   EMBL; AMGL01095809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01095810; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01095811; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01095812; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01095813; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01095814; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01095815; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01095816; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01095817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004009642.1; XM_004009593.3.
DR   RefSeq; XP_012034812.1; XM_012179422.2.
DR   Ensembl; ENSOART00000019384; ENSOARP00000019116; ENSOARG00000017811.
DR   GeneID; 101111805; -.
DR   KEGG; oas:101111805; -.
DR   CTD; 9348; -.
DR   GeneTree; ENSGT00760000119023; -.
DR   KO; K02578; -.
DR   OMA; TVIHDLG; -.
DR   OrthoDB; EOG091G02CP; -.
DR   Proteomes; UP000002356; Chromosome 6.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015016; F:[heparan sulfate]-glucosamine N-sulfotransferase activity; IEA:Ensembl.
DR   GO; GO:0042328; F:heparan sulfate N-acetylglucosaminyltransferase activity; IEA:Ensembl.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   GO; GO:0015014; P:heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; IEA:Ensembl.
DR   InterPro; IPR021930; Heparan_SO4_deacetylase.
DR   InterPro; IPR037359; NST/OST.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000863; Sulfotransferase_dom.
DR   PANTHER; PTHR10605; PTHR10605; 1.
DR   Pfam; PF12062; HSNSD; 1.
DR   Pfam; PF00685; Sulfotransfer_1; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     29     48       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       34    520       HSNSD. {ECO:0000259|Pfam:PF12062}.
FT   DOMAIN      610    859       Sulfotransfer_1. {ECO:0000259|Pfam:
FT                                PF00685}.
SQ   SEQUENCE   887 AA;  102360 MW;  C59AEBC8FBFADD92 CRC64;
     MVLLLEQSEE SICNMSFIMK LHRHFQRTVI LLATFCMVSI IISAYYLYSG YKQENELSEM
     ALEVDCGDLQ HLPYRLMGVK PAKLSDASRT DTTVLVFVES QYSSLGQDII MILESSRFQY
     HIEIAPGKGD LPALTEKSRG KYSLIIYENI LKYIHMDSWN RSLLDKYCVE YGVGVIGFHR
     TSEKSPQSFQ LKGFPFSVYG SLAVKDCCIN PHSPLLHVTK SSKLEKGSLP GTDWTVFQIN
     HSAYQPVIFA KVKTPENLSP PISKGAFYAT VIHDLGLHDG IQRVLFGNNL NFWLHKLIFI
     DAVSFLSGKR LTLSLDRYIL VDIDDIFVGK EGTRMNTNDV KALLDTQNLL RAQITNFTFN
     LGFSGKFYHT GTEEEDEGDD HLLGSVDEFW WFPHMWSHMQ PHLFHNESSL VEQMILNKKF
     ALEHGIPTDM GYAVAPHHSG VYPVHVQLYE AWKKVWNIRI TSTEEYPHLK PARYRRGFIH
     KNIMVLPRQT CGLFTHTIFY KEYPGGPKEL DKSIQGGELF FTVVLNPISI FMTHLSNYGN
     DRLGLYTFVN LANFVQSWTN LRLQTLPPVQ LAHKYFELFP DQKDPLWQNP CDDKRHRDIW
     SKEKTCDRLP KFLVIGPQKT GTTALYLFLV MHPSILSNSP SPKTFEEVQF FNRNNYHRGI
     DWYMDFFPVP SNVTTDFLFE KSANYFHSEE APKRAASLVP KAKIITILID PSDRAYSWYQ
     HQRSHEDPAA LKFSFYEVIS AGPRAPSELR ALQKRCLVPG WYASHIERWL VYFPPFQLLI
     IDGQQLRTDP ATVMDEVQKF LGVSPHYNYS EALTFDSHKG FWCQLLEEGK TKCLGKSKGR
     KYPPMDPDSR AFLSSYYRDH NVELSKLLHR LGQPLPSWLR QELQKVR
//
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