ID W5Q970_SHEEP Unreviewed; 553 AA.
AC W5Q970;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Reverse transcriptase domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000019262.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000019262.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000019262.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000019262.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the beta type-B retroviral polymerase family.
CC HERV class-II K(HML-2) pol subfamily. {ECO:0000256|ARBA:ARBA00010879}.
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DR EMBL; AMGL01115979; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5Q970; -.
DR SMR; W5Q970; -.
DR PaxDb; 9940-ENSOARP00000019262; -.
DR Ensembl; ENSOART00000019530.1; ENSOARP00000019262.1; ENSOARG00000017947.1.
DR eggNOG; KOG0017; Eukaryota.
DR HOGENOM; CLU_011494_2_0_1; -.
DR OMA; CQWYVAH; -.
DR Proteomes; UP000002356; Chromosome X.
DR Bgee; ENSOARG00000017947; Expressed in epididymis and 40 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR010661; RVT_thumb.
DR PANTHER; PTHR41694:SF4; ENDOGENOUS RETROVIRUS GROUP K MEMBER 10 POL PROTEIN-RELATED; 1.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR Pfam; PF00075; RNase_H; 1.
DR Pfam; PF00078; RVT_1; 1.
DR Pfam; PF06817; RVT_thumb; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW ERV {ECO:0000256|ARBA:ARBA00022783};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 42..230
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 440..553
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
SQ SEQUENCE 553 AA; 63457 MW; 954808117FF7FF2C CRC64;
ATAQIPRALP LKLLTNTPKW VEQWPLPQIK LEALEQLVQE QLQLGHIEPS TSPWNSPIFV
ILKKSRKWKM LTDLREVNKC IEPMGALQLG LPSPALIPQN WSLMVLDLKD CFFTIPLQLQ
DRDKFAFTIP VLNHAQPVKR YQWTVLPQGM TNSPTLCQEF IARSLQSLRQ EYPNYILYHY
MDDLLLAAPS IAERDEFFLK VQEALRLYNL QIAPEKIQKD FPISYLGTIL EQHRIRPQKL
QIRRDHLKTL NDFQKLLGDI NWLRPVLGIP TYQFSTLEGD TALDSPRTLT PLALQELQFV
EQRLNDGFLT YLHASQPISF ITFHTPYSPS GVIAQEKGLI GWIFLPNSFS KKLTIYMDKL
AFLIQKGRHR ILQLSECEPH QIVTQLTTAQ ISRCLQFNKN WQISLASFPG SFSNHYPSSK
LIDFLRTNSM ISQSPISDIP VKGPTIFTDA NNTAGYWTPE NSKVLPHSFS SVQPIELWAI
YLVLQDFPQL PINIVSDSRY AVLSCLQLPH VSLPLTLKTA IDKLFYQVQQ LLLQRSKLIF
FTHIHAHSAL PGP
//
