ID W5QBQ9_SHEEP Unreviewed; 1930 AA.
AC W5QBQ9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Myosin-9 {ECO:0000256|ARBA:ARBA00039816};
DE AltName: Full=Myosin heavy chain 9 {ECO:0000256|ARBA:ARBA00041440};
DE AltName: Full=Myosin heavy chain, non-muscle IIa {ECO:0000256|ARBA:ARBA00042289};
DE AltName: Full=Non-muscle myosin heavy chain IIa {ECO:0000256|ARBA:ARBA00043098};
GN Name=MYH9 {ECO:0000313|Ensembl:ENSOARP00000020156.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000020156.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000020156.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000020156.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000020156.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, Cortical
CC granule {ECO:0000256|ARBA:ARBA00037865}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; AMGL01082252; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01082253; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR SMR; W5QBQ9; -.
DR STRING; 9940.ENSOARP00000020156; -.
DR PaxDb; 9940-ENSOARP00000020156; -.
DR Ensembl; ENSOART00000020436.1; ENSOARP00000020156.1; ENSOARG00000018760.1.
DR eggNOG; KOG0161; Eukaryota.
DR HOGENOM; CLU_000192_4_0_1; -.
DR OMA; QRAMDIE; -.
DR Proteomes; UP000002356; Chromosome 3.
DR Bgee; ENSOARG00000018760; Expressed in leukocyte and 52 other cell types or tissues.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 3.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.30.70.1590; -; 1.
DR Gene3D; 6.10.250.2420; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 4.10.270.10; Myosin, subunit A; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF16; MYOSIN-9; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 3.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 1.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF57997; Tropomyosin; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Cell shape {ECO:0000256|ARBA:ARBA00022960};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 27..77
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 81..778
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 656..678
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1842..1874
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1897..1930
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 842..1262
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1336..1391
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1842..1873
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1902..1930
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 174..181
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1930 AA; 220834 MW; E1F0C8D5950425DF CRC64;
MAQQAADKYL YVDKNFINNP LAQADWAAKK LVWVPSDKSG FEPASLKEEM GEEAIVELVE
NGKKVKVNKD DIQKMNPPKF SKVEDMAELT CLNEASVLHN LKERYYSGLI YTYSGLFCVV
INPYKNLPIY SEEIVEMYKG KKRHEMPPHI YAITDTAYRS MMQDREDQSI LCTGESGAGK
TENTKKVIQY LAHVASSHKS KKDQGELERQ LLQANPILEA FGNAKTVKND NSSRFGKFIR
INFDVNGYIV GANIETYLLE KSRAIRQAKE ERTFHIFYYL LSGAGEHLKS DLLLESYNKY
RFLSNGHVTI PGQQDKDMFQ ETMEAFRIMG IPEEEQMAQG LLRVISGVLQ LGNIVFKKER
NSDQASMPDN TAAQKVSHLL GINVTDFTRG ILTPRIKVGR DYVQKAQTKE QADFAIEALA
KATYERMFRW LVLRINKALD KTKRQGASFI GILDIAGFEI FDLNSFEQLC INYTNEKLQQ
LFNHTMFILE QEEYQREGIE WNFIDFGLDL QPCIDLIEKP AGPPGILALL DEECWFPKAT
DKSFVEKVMQ EQGTHPKFQK PKQLKDKADF CIIHYAGKVD YKADEWLMKN MDPLNDNIAT
LLHQSSDKFV SELWKDVDRI IGLDQVAGMS ETAMPGAFKT RKGMFRTVGQ LYKEQLAKLM
ATLRNTNPNF VRCIIPNHEK KAGKLDPHLV LDQLRCNGVL EGIRICRQGF PNRVVFQEFR
QRYEILTPNS IPKGFMDGKQ ACVLMIKALE LDSNLYRIGQ SKVFFRAGVL AHLEEERDLK
ITDVIIGFQA CCRGYLARKA FAKRQQQLTA MKVLQRNCAA YLKLRNWQWW RLFTKVKPLL
QVSRQEEEMM AKEEELVKVR EKQLAAENRL SEMETLQSQL MAEKLQLQEQ LQAETELCAE
AEELRARLTA KKQELEEICH DLEARVEEEE ERCQHLQAEK KKMQQNIQEL EEQLEEEESA
RQKLQLEKVT TEAKLKKLEE DQIIMEDQNC KLAKEKKLLE DRIAEFTTNL MEEEEKSKSL
AKLKNKHEAM ITDLEERLRR EEKQRQELEK TRRKLEGDST DLNDQIAELQ AQIAELKMQL
AKKEEELQAA LARVEEETTQ KNMALKKIRE LESQISELQE DLESERAARN KAEKQKRDLG
EELEALKTEL EDTLDSTAAQ QELRSKREQE VNILKKTLEE EARTHEAQIQ DMRQKHSQAV
EELAEQLEQT KRVKANLEKA KQTLENERGE LANEVKVLQQ GKADTEHKRK KVEAQLQELQ
VKFTEGERVR TELADKVSKL QVRPFSAWGL VTPSTRVLWS VILTVPGGPV DSLGLDQAHL
GPESVRAPEL SAPPQVREME AELEDERKQR SIAVAARKKL EMDLKDLEAH IDSANKNRDE
AIKQLRKLQV SSGWSDPAAY SSIGPSTGLD TAGLACCYTD ADPEAEWRQN IISKIVDFTL
NKETSVKLKV QWRYSHLVTQ WQFSTTSQTR LSPALMDSDR RFQADESGQQ SRNRTHAWPL
STSGAGKVVG CRCIDGGSLA GTTWPHTTKL VPSGLGNPSL GFTYKRKERK KVCPRIFRVR
MNHRRTKDIG LCLVAENQPP VPVGEVSSGA GAGVGGAREW LGASLLRPQA QMKDYMRELD
DTRASREEIL AQAKENEKKL KSMEAEMIQL QEELAAAERA KRQAQQERDE LADEIANSSG
KGALALEEKR RLEARIAQLE EELEEEQGNT ELVNDRLKKA NLQIDQLNTD LNLERSHTQK
NENARQQLER QNKELKVKLQ EMEGTVKSKY KASITALEAK IAQLEEQLDN ETKERQAACK
QVRRAEKKLK DVLLQVDDER RNAEQYKDQA DKASTRLKQL KRQLEEAEEE AQRANASRRK
LQRELEDATE TADAMNREVS SLKNKLRRGD LPFVVPRRMA RKGASDCSDD EMDGKADGAE
AKAAEARAAE
//
